Journal of Bangladesh Society of Physiologists

Permanent URI for this collection

https://imsear.searo.who.int/handle/123456789/149643

Editor: Professor Dr Shah Abdul Latif,

ISSN1995-1213; (Online)

Frequency: 2 issues a year

Language: English

Official Journal of the Bangladesh Society of Physiologist.

Open Access Peer-reviewed journal

Web site: https://www.banglajol.info/index.php/JBSP/

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Serum High Sensitive C - reactive protein in Male Smokers of Bangladesh.
(2015-06) Jahan, Shamima; Akhter, Qaz Shamima
Background: Smoking may cause systemic inflammation, and high level of serum high sensitive Creactive protein may be found in smoker as an indicator of inflammation. Objective: To assess the serum high sensitive C - reactive protein level in male smokers of Bangladesh. Methods: The present cross sectional study was carried out in the Department of Physiology, Dhaka Medical College, Dhaka between July 2013 and June 2014. Hundred apparently healthy male regular cigarette smokers aged 20 to 40 years who smokes at least 5 sticks of cigarette per day for the last 5 years were included as study group. They were further divided in to 5-10 years, 11-15 years, 16-20 years and 1-10 cigarette sticks, 11- 20 cigarette sticks, more than 20 cigarette sticks/day depending on the duration of smoking and also according to consumption of number of sticks/day respectively. Age matched 100 apparently healthy male nonsmokers were included for control. To assess their inflammatory status, serum hs-CRP level was estimated by particles enhanced immunonephelometry using BN Systems in the Department of Microbiology & Immunology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. In addition, BMI and blood pressure were measured by standard method to observe their association with smoking. Results: The mean serum hs-CRP level was significantly higher in male smokers than that of non smokers which was progressively increased with duration of smoking and number of cigarette sticks consumed per day. Again, mean BMI was significantly lower and diastolic blood pressure was significantly higher in male smokers than those of non smokers. Conclusion: The result of this study can be concluded that serum hs-CRP level progressively increases with duration of smoking and number of cigarette sticks consumed per day in male smokers.
Antinociceptive and Anti-inflammatory Effects of Combined Administration of a-tocopherol and Diclofenac.
(2015-06) Juaira, Tasneema; Begum, Noorzahan; Ali, Taskina
Background: Nonsteroidal anti-inflammatory drugs such as diclofenac are used for relief of pain and inflammation, but frequently cause gastrointestinal complications. This study aimed to explore that combination of diclofenac and α-tocopherol (αT) are better analgesic as well as anti-inflammatory agent than that of diclofenac alone. Objective: To assess the effects of combination of diclofenac with α-tocopherol on pain and inflammation. Methods: This prospective experimental study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka between January to December 2013. For this purpose, 15 male Long Evans rats were studied. On the basis of vitamin and drug administrations, the rats were divided into three (3) groups (5 rats in each). Control group received normal saline, one experimental group received diclofenac sodium (DS) at a dose of 10 mg/kg/body weight, and another experimental group received combination of DS with αT at a dose of 10 mg/kg/body weight and 500mg/kg/body weight, respectively. All the groups received single dose and equal volume (1 ml) through intraperitoneal route 1 hour before the test. Just one hour after administrations, they were subjected to formalin test followed by formalin induced paw edema test. The data were statistically analyzed by ANOVA followed by Bonferroni Post Hoc test. Results: Combined administration of DS and αT significantly (p<0.001) lowered the variables for nociceptive pain, central analgesic activity, inflammatory pain and inflammation than individual intervention of DS. Conclusion: From this study it may be concluded that, combined administration of diclofenac sodium and ±-tocopherol were more effective in lowering pain and inflammation than individual administration of diclofenac.
Coagulation Impairment in Type 2 Diabetes Mellitus.
(2015-06) Karim, Fayeza; Akter, Qazi Shamima; Jahan, Shamima; Khanom, Afruza; Haque, Samira; Yeasmin, Tania; Siddika, Tashfia; Sinha, Susmita
Background: Complication of diabetes mellitus (DM) includes coagulation impairment. Hypercoagulable state in patient with DM may accelerate thromboembolic risk for cardiovascular disease (CVD). Objective: To assess Prothrombin Time and Activated Partial Thromboplastin Time in type 2 diabetes mellitus for observing their coagubility status. Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2013 to June 2014. One hundred male patients with type 2 diabetes mellitus aged 40-60 years and one hundred age, BMI matched healthy subjects were included as control in this study. Patients were selected from BIRDEM, Dhaka. Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT) were estimated by auto analyzer. For statistical analysis unpaired student’t test was used. Results: In this study PT and APTT were significantly (P<0.001) lower in diabetes mellitus than those of control group. Conclusion: From this study, it may be concluded that diabetic patients are prone to develop coagulation impairment.
Effect of Combined Oral Contraceptive Pill on FVC, FEV1 and FEV1/FVC%.
(2015-06) Islam, Farhana; Jahan, Nasim; Sultana, Nayma
Background: Combined oral contraceptive pill (COCP) is the most commonly used contraceptive method in Bangladesh. This COCP may have some effects on different organs including lungs. Objective: To observe the effects of combined oral contraceptive pill (COCP) on FVC, FEV1 and FEV1/ FVC% in apparently healthy women receiving COCP. Methods: This cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka between July 2013 and June 2014. A total 30 apparently healthy young women, age ranged 20 to 30 years were included in this study who were combined oral contraceptive pill users (COCP-U) for at least 6 months. Thirty age and BMI matched combined oral contraceptive pill nonusers (COCP-NU) were taken as control. FVC, FEV1 and FEV1/FVC% of all the subjects were measured by digital spirometer. Statistical analysis was done by Independent sample ‘t’ test. Results: FVC (p<0.001), FEV1 (p<0.001) were significantly higher whereas, FEV1/FVC% (p<0.05) was significantly lower in COCP-U than those of COCP-NU. Moreover, the mean serum estrogen (p<0.001) and progesterone (p<0.05) levels were also significantly higher in COCP-U in comparison to those of COCP-NU. Conclusion: From the result of this study it can be concluded that COCP have beneficial effects on some pulmonary function parameters.
Relationship of Sympathetic Dysfunction with Disease Duration In Female Rheumatoid Arthritis Patients.
(2015-06) Ferdousi, Sultana; Jahan, Kowser; Begum, Noorzahan
Background: Association of increased cardiovascular morbidity and higher sympathetic activity in patients with Rheumatoid arthritis (RA) has been well recognized. Objective: To assess sympathetic nerve function status in Rheumatoid arthritis patients and its relationship to duration of the disease. Methods: This study was carried out in the dept of Physiology Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka during 2010.Sixty female RA patients aged 18-50 years with duration of disease from 1 to 10 years was selected from Rheumatology wing of Medicine OPD of BSMMU. Age and BMI matched female apparently healthy subjects were control. Sympathetic nerve function status was assessed by blood pressure response to orthostatic test and sustained hand grip isometric exercise test. In these two tests, fall in systolic blood pressure (SBP) and rise in diastolic blood pressure (DBP) respectively estimates sympathetic reactivity. For statistical analysis, unpaired students t test and pearsons correlation coefficient test was applied. Results: Mean values of fall of SBP was higher and rise of DBP was lower in RA patients compared to control which was statistically (P<0.001) significant. Again rise of DBP was negatively and fall of SBP was positively correlated with duration of the disease and the relationships were statistically highly significant (p<0.01). Conclusion: The results conclude that sympathetic reflex response was reduced in RA which was deteriorated with duration of disease.
Effect of Peanut (Arachis Hypogaea L.) on Dyslipidemia in Young Adult.
(2015-06) Akter, Hasina; Jahan, Nasim; Sultana, Nayma
Background: Dyslipidemia is a major risk factor for cardiovascular disease. Lipid lowering drugs are available in modern medicine but prolong use of these drugs may produce some side effects. Peanut due to some of its active component can improve lipid profile. Objective: To observe the effects of peanut (Arachis hypogaea L.) on dyslipidemia in young adults. Methods: This prospective interventional study was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka between 1st July 2013 and 30th June 2014. For this purpose 30 dyslipidemic young adults of both sexes with aged 30 to 40 years were included in this study and they were selected from Out Patient Department of Medicine of Sir Salimullah Medical College and Mitford Hospital, Dhaka. They were studied three times i,e before supplementation with peanut (BSP), after 4 weeks supplementation with peanut (4 wks AP) and after 8 weeks supplementation with peanut (8 wks AP). For assessing lipid profile TAG, LDL-C, TC and HDL-C of all subjects were estimated by enzymatic method. The statistical analysis was done by using paired sample‘t’ test as applicable. Results: In this study, the mean serum TAG, LDL-C and TC levels were significantly decreased after 8 weeks supplementation with peanut in comparison to those of after 4 weeks and before supplementation with peanut. However, these levels were also decreased after 4 weeks supplementation than those of before supplementation but it was significant only for TC (p<0.05) and LDL-C (p<0.001). Whereas, the mean serum HDL-C level was significantly (p<0.001) increased after 8 weeks supplementation when compared to those of after 4 weeks and before supplementation of peanut. Conclusion: The present study revealed that, peanut (Arachis hypogaea L.) has effect on improvement of lipid profile by lowering serum TAG, LDL-C, TC levels and by increasing serum HDL-C level. This lipid lowering effects of peanut may be due to its high Mg+2 content and other active components of peanut.
Effect of Moderate Physical Exercise on Autonomic Balance in Irritable Bowel Syndrome.
(2015-06) Tenzin, Karma; Begum, Noorzahan; Ferdousi, Sultana
Background: Altered autonomic balance has been noted in Irritable bowel syndrome Regular physical exercise may cause restoration of autonomic balance in health and disease. Objective: To assess the effect of brisk walking on the autonomic balance by analysis of heart rate variability in patients with Irritable bowel syndrome (IBS). Methods: This prospective study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU) in 2013.Seventy seven male IBS patients aged 20-50 years, were enrolled from Gastroenterology OPD, BSMMU, Dhaka. Twenty eight healthy sedentary male with similar age were control. HRV measures were recorded once prior to exercise and then after 3 months of brisk walking. For assessing autonomic balance, LF/HF ratio and Max/Min RR was evaluated by Polyrite D machine and software. ANOVA, Independent sample t-test and paired t-test were used for statistical analysis. Results: The pre-exercise mean values of LF/HF ratio were significantly higher (p<0.001) in all IBS patients compared to those of control. The post exercise LF/HF ratio were significantly lower (p<0.05) in all IBS patients compared to their pre-exercise values. Conclusion: This study concluded that the sympathovagal balance was towards sympathetic predominance in IBS and regular moderate physical exercise may shift the balance towards parasympathetic predominance in them.
Effect of Terminalia Chebula (Haritaki) on Serum Aspartate Aminotransferase, Alanine Aminotransferase in Paracetemol induced liver damage in Wister Albino Rats.
(2015-06) Yeasmin, Tania; Akhter, Qazi Shamima; Siddika, Syeda Tasfia; Karim, Fayeza
Background: Liver plays a major role in detoxification and excretion of many endogenous and exogenous compounds. Any injury may lead to severe liver damage and impairment of liver function. Harbal plants such as Terminalia chebula (Haritaki) may have free radical scavenging activity thereby can be used for the prevention and treatment of liver damage. Objective: To observe the effect of Terminalia chebula on paracetamol induced changes of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in Wister albino rats. Methods: This experimental study was carried out in the Department of Physiology, Dhaka Medical College, Dhaka from January to December’ 2013. Total 44 rats with age 90 to 120 days, weighing between 150 to 200 gm were selected. After acclimatization for 14 days, they were divided into base line control (BC, n=11), paracetamol treated control (PC, n=11),Terminalia chebula pretreated and paracetamol treated (TCP-PCT n=11) and paracetamol pretreated and Terminalia chebula treated group (PCP-TCT, n=11). All groups received basal diet for 21 consecutive days. In addition to basal diet, rats of BC received propylene glycol (2ml/kg body weight, orally) and PC received single dose of paracetamol suspension (750mg/kg body weight, orally) on 21st day. Rats of TCP-PCT received Terminalia chebula extract (200 mg/kg body weight, orally) for 21 consecutive days and paracetamol suspension (750mg/kg body weight, orally) on 21st day. Again, rats of PCP-TCT received paracetamol suspension (750mg/kg body weight, orally) on the 1st day and Terminalia chebula extract (200 mg/kg body weight orally) for 21 consecutive days. All rats were sacrificed on 22nd day and then blood samples were collected. For assessment of liver function serum AST and ALT levels were estimated by using standard laboratory kits. The statistical analysis was done by one way ANOVA and post hoc Bonferroni test as applicable. Results: The mean serum AST and ALT levels were significantly (p<0.001) higher in PC in comparison to those of BC. Serum AST and ALT levels of all experimental groups were significantly (P<0.001) lower than PC group. Conclusion: From the results of this study, it may be concluded that Terminalia chebula may have some hepatoprotective effects in paracetamol induced liver damage in rats.
Goitrogenic and Antithyroid Potential of Green Tea Of Indian Origin.
(2014-12) Chandra, Amar K; De, Neela
Polyphenolic flavonoids, specially catechins are major constituents of tea. Antithyroidal and goitrogenic effect of flavonoids have been reported however such effects of green tea on thyroid physiology has not been explored earlier. Green tea is derived from the tea leaves of Camellia sinensis and widely consumed globally. The green tea extracts(GTE) at different concentrations (1.25g% a” 5 cups of tea/ day; 2.5g% a” 10 cups of tea/ day and 5.0g% a” 20 cups of tea/ day) were orally fed to male rats for 30 days. Similarly, pure catechin was administered orally to male albino rats for 30 days at doses of 25, 50 and 100 mg/kg body weight that are equivalent to above doses of green tea extract in terms of its total catechin content and the morphological and functional changes of the thyroid have been investigated. The overall results reveal that oral administration of green tea extract at 2.5g% and 5.0g% concentrations for 30 days changed the morphology and histology resembling hypertrophy of thyroid follicles with differential colloid sizes as found in hypothyroid due to environment influences associated with significant inhibited activities of thyroid peroxidase(TPO) and 5’ monodeiodinase (5’ DI1) with elevated Na+,K+ ATPase and concomitant decrease in serum thyroxine (T4), triiodothyronine (T3) and increase in serum thyrotropin (TSH) levels developing a state of absolute biochemical hypothyroidism. All these suggest that catechin present in green tea has the antithyroidal as well as goitrogenic potential and its regular consumption at relatively high doses pose a threat to the functioning of thyroid.
Pre Clinical- Basic Sciences Teaching Curriculum Of A Medical School in A Developing Country -Are We Doing It Right.
(2014-12) Atukorala, Kushani Rasangika; Atapattu, Piyusha
Background: Preclinical teaching of basic sciences provides the basis for the development of clinical reasoning skills and the ability to make management decisions. However, many senior undergraduates, pre-interns and doctors indicate that basic sciences knowledge is poorly recalled and has little relevance to their clinical practice. Objectives: To explore the perceptions of medical students in their clinical years, and pre-interns about the basic sciences courses taught to them in the preclinical years, and to assess how each group rates the applicability of these courses to current clinical training. Methods: A descriptive cross-sectional study was conducted among 118 pre-interns and 146 undergraduate medical students using a self-administered questionnaire, regarding their perceptions on preclinical basic sciences teaching. For statistical analysis chi square test was applied. Results: More than 75% both pre-interns and undergraduates agreed that preclinical teaching was useful and relevant for future clinical work. 50-75% frequently revisited preclinical subjects despite unapparent clinical significance. 55% couldn’t remember most of preclinical content. Physiology was the most retained (76%) and most clinically relevant subject (80%). Majority of (>60%) both the groups suggested more teaching time and >75% suggested concurrent clinical exposure for preclinical teaching. Undergraduates and preinterns differed in that 56% of undergraduates and 37% of pre-interns had studied pre clinical subjects just to pass examinations (p<0.01).Conclusions: Majority of undergraduates and pre-interns felt that preclinical teaching is interesting and relevant for future clinical practice, though recall and clinical significance were suboptimal. Revising teaching methods with interdisciplinary integration, early clinical exposure showing relevance of basic sciences and allocating more teaching time utilizing clinicians should be considered.
Non- Pharmacological Measures For Control of Hypertension in Geriatric Population.
(2014-12) Sahoo, Debalina; Gosai, Harshida; Sahoo, Ujjwal; Harsoda, JM
Background: Increased prevalence of hypertension in all over the world is well recognized. Hypertension affects almost all body organs and systems. It can be managed by using nonpharmacological measures as well. Objective: To assess knowledge of non-pharmacological measures to control of hypertension and its application in geriatric hypertensive population. Methods: The study was conducted in the Department of Physiology, Sumandeep Vidyapeeth University, Vadodara. Total 108 hypertensive patients had been included for this study. Subjects were administered pre tested ten questionnaires. They responded the questionnaires at the same time, without any discussion. Results: Knowledge about normal level of blood pressure was lacking in 70% of study population. Conclusion: Knowledge about weight reduction, regular exercise, fruits and vegetables intake was poor. About half of the study population said that blood pressure can be controlled by using of drugs only. So, they were not aware of non-pharmacological measures.
Histomorphometric Study of the Proportion of Different Zones of Adrenal Cortex – A Postmortem Study.
(2014-12) Siddiqua, Dilruba; Nurunnabi, Abu Sadat Mohammad; Johora, Fatema; Hena, Hasna; Shahriah, Sunjida; Ara, Shamim
Background: The human adrenal cortex shows a distinct proportion of three zones, named zona glomerulosa, zona fasciculate & zona reticularis, from outer inwards, in its histological appearance with differences in its cellular components and functions. Objective: The aim of the present study was to see the variation in the proportion of zones of the adrenal cortex in different age-group in a Bangladeshi population. Methods: This cross-sectional, descriptive study was done in the Department of Anatomy, Dhaka Medical College, Dhaka, from July 2008 to June 2009, based on collection of 140 post mortem human adrenal glands from 70 unclaimed dead bodies which were in the morgue under examination in the Department of Forensic Medicine, Dhaka Medical College, Dhaka. The samples were divided into four age-groups including A (11-20 years), B (21-30 years), C (31-40 years) & D (41-60 years). Histological slides were prepared by using routine haematoxylin and eosin stain (H & E). Five best prepared slides from each group were examined under light compound microscope with low magnification. The thickness of different layers adrenal cortex were measured by using ocular and stage micrometer and then converted into percentage volume. Results: The mean volume of the zona glomerulosa, zona fasciculata and zona reticularis of the right adrenal cortex were found 14.16±0.79%, 78.40±1.14%, 7.44±0.52% in group A; 14.58±0.38%, 78.00±0.71%, 7.42±0.38% in group B; 14.34±0.83%, 78.56±0.52%, 7.30±0.50% in group C; 14.08±1.23%, 78.80±1.10%, 7.10±0.22% in group D respectively. The mean volume of the zona glomerulosa, zona fasciculata and zona reticularis of the left adrenal cortex were found 14.66±0.34%, 78.84±0.82%, 7.72±0.48% in group A; 14.62±0.30%, 78.54±0.84%, 7.58±0.43% in group B; 14.90±0.96%, 79.20±0.45%, 7.34±0.42% in group C; 14.70±1.25%, 79.40±0.55%, 7.30±0.35% in group D respectively. Conclusion: No difference was found statistically significant in the percentage volume of the three zones of the adrenal cortex with advancing age in Bangladeshi people.
Cadaveric Study of The Anatomical Variations of The Accessory Pancreatic Duct.
(2014-12) Shahriah, Sunjida; Nurunnabi, Abu Sadat Mohammad; Johora, Fatema; Siddiqua, Dilruba; Ara, Shamim
Background: The accessory pancreatic duct enters the duodenum at the minor duodenal papilla, developmentally draining the dorsal pancreatic bud; however, it is smaller and less constant than the main pancreatic duct and undergoes varying degrees of atrophy at the duodenal end. Objective: The objective of this study was to see the variations in course, opening and communication pattern of the accessory pancreatic duct in different age-groups in a Bangladeshi population. Methods: This crosssectional, descriptive study was done was done in the Department of Anatomy, Dhaka Medical College, Dhaka, from August 2005 to December 2006, based on collection and dissection of 75 postmortem male human pancreas. The collected samples were divided into seven age groups: 10-19 years, 20-29 years,30-39 years, 40-49 years, 50-59 years),60-69 years and(eˆ70 years. However, 65 samples were taken for final observation. Results: The accessory pancreatic duct was found in 27.69% specimens. Straight course was found in 50% specimen, while spindle course in 27.78% and cudgel course in 22.22% specimens were observed. In only 4 (6.15%) specimens, the accessory pancreatic duct communicates with the common bile duct, while in 11 (16.93%) specimens, the accessory pancreatic duct communicates with the main pancreatic duct. 12 (66.67%) accessory pancreatic ducts opened into the minor duodenal papilla, while 5 (27.78%) into the major duodenal papilla and 1 (5.55%) into the 3rd duodenal papilla. Conclusion: Several variations were observed in accessory pancreatic duct pattern in terms of their course, opening and communications. However, no significant differences were evident in any parameter among the age groups. Here, females were excluded due to less availability of the female cadaveric pancreas during study period.
Effect of Aging On Short Term Heart Rate Variability.
(2014-12) Akhter, Qazi Farzana; Akhter, Qazi Shamima; Rohman, Farhana; Sinha, Susmita; Ferdousi, Sybilla
Background: Heart rate variability has been considered as an indicator of autonomic nerve function status. Few works have been done to assess the heart rate variability in normal healthy subjects in different countries. Objectives: To assess the cardiac autonomic nerve function status in healthy Bangladeshi population of different age groups by analyzing time domain measures of Heart Rate Variability. Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from the period of July 2012 to June 2013. For this purpose, a total number of 180 healthy subjects were selected with the age ranging from 15-60 years of both sexes. All the study subjects were divided into 3 different groups according to age (Control 15-30 years; middle age 31-45 years; older age 46-60 years). Each group included 60 subjects of which 30 were male and 30 were female. The subjects were selected from different areas of Dhaka city by personal contacts. HRV parameters were recorded by a 4 active channels, RMS Polyrite-D-2 machine For statistical analysis, one way ANOVA, unpaired Student’s ‘t’-test and Pearson’s correlation coefficient test were performed. as applicable. Results: Systolic blood pressure (SBP), diastolic blood pressure (DBP) were significantly (p<0.001) higher in older group in comparison to control & middle age group. Again RR interval and RMSSD (p<0.001), were significantly lower in older age group (p<0.05) compared to control & also to middle age group. But HR was found significantly higher (p<0.05)in both middle and older subjects than control and also in older (p<0.05) compared to middle age. Correlation analysis showed moderate negative correlation of mean R-R with age in middle age whereas significant negative correlation for RMSSD both in middle and older age subjects.. Conclusion: In this study, markedly decreased cardiac parasympathetic function were found with aging process.
Insulin Secretory Status in Obese Female.
(2014-12) Tasnim, Masuma; Akhter, Qazi Shamima; Akhter, Salma; lovely, Nasreen Sultana; Begum, Khadiza; Sinha, Susmita
Background: In obesity insulin hypersecretion is a key feature indicating the abnormal pancreatic beta cell function which is the fundamental defect in the development of NIDDM, hypertension and cardiovascular diseases. Objective: To assess the secretory status of insulin in adult obese female. Methods: The present study was a cross sectional analytical study and conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2012 to June 2013. 50 obese female subjects of 20-40 years were included from Out-patient Department (Obesity clinic) of BIRDEM Hospital, Dhaka and by personal contact from different areas of Dhaka city. 50 age matched, healthy non-obese female subjects selected as controls . Fasting serum insulin level was measured by ELISA and fasting glucose level was measured by Glucose oxidase method. The insulin secretory status was calculated by HOMA-%B using HOMA software. For statistical analysis unpaired Student’s ‘t’ test and Pearson’s correlation coefficient (r) test were performed as applicable . Result: Mean fasting serum insulin and HOMA%B (P<0.001) were higher in the obese than that non obese. Fasting serum insulin level and HOMA%B showed significantly positive correlation with WHR. Conclusion: This study concludes that obese individual develops a state of insulin hypersecretion and hyperinsulinemia.
Effects of Pulmonary Rehabilitation on Exercise Tolerance in Patients with COPD.
(2014-12) Ahmed, Mohammad Nesar Uddin; Begum, Shelina; Ali, Taskina
Background: Pulmonary rehabilitation (PR) is known to be therapeutically useful for COPD patients. Objective: To evaluate the effects of combination of breathing exercises (pursed lip breathing and diaphragmatic breathing) and lower extremity endurance training (LEET) as part of PR program on six minute walk distance (6MWD), on oxygen saturation (SpO2%), on the level of dyspnea and fatigue in patients with moderate stable COPD. Methods: This prospective study was conducted in the Department of Physiology, BSMMU, Dhaka from July 2010 to June 2011 on 116 male stable moderate COPD patients aged 50 to 65 years. They were enrolled from the out patient department (OPD) of the Department of Medicine of BSMMU and NIDCH Dhaka. 56 patients without PR constituted control group and experimental group included 60 patients intervened with PR. The experimental patients were advised to perform the PR program for 30 minutes duration per session at home twice daily, for consecutive 60 days along with the standard drug treatment of COPD. The control patients were advised to continue their standard drug treatment alone for consecutive 60 days. For the assessment of exercise tolerance, 6MWD, SpO2%, the level of dyspnea and fatigue of all subjects were recorded on day 0 and day 60 for both the groups. SpO2% was recorded by portable Pulse Oximeter and the level of dyspnea as well as fatigue were recorded by Modified Borg Scale. Statistical analysis was done by independent sample ‘t’ test and paired sample ‘t’ test. Results: Significant improvement were observed in 6MWD, SpO2%, the level of dyspnea and fatigue in patients who performed PR program. In addition, significant improvement in these parameters were observed after completing PR program compared to the beginning of the intervention. Conclusion: The study concludes that regular exercise of all components of PR program significantly improve exercise tolerance in COPD patients.
Acute Effect of Cigarette Smoking On HRV in Current Cigarette Smokers.
(2014-12) Ferdous, Mehboba; Ferdousi, Sultana
Background:Cigarette smoking induced increased sympathetic activity is one of the major independent risk factor for cardiac morbidity and mortality. Objective:To assess acute effects of smoking on neuro cardiovascular regulation by analysis of time domain measures of HRV in current regular healthy male cigarette smoker. Methods:This comparative analytical study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka from July 2011 to June 2012. 120 apparently healthy male current regular cigarette smoker aged 20-55 years were participated in the study group. Age and BMI matched 70 apparently healthy male non smoker subjects were studied as control. To observe the acute effects data were recorded 5 and 30 min after finishing a cigarette. Time domain measures of HRV were recorded by a RMS digital polyrite D. Statistical analysis was done by independent sample t test and paired sample t test.Results: Resting pulse rate, SBP, DBP, mean heart rate were significantly higher (p<0.001) and mean R-R interval, SDNN, RMSSD and total power were significantly lower (p<0.001) in all smokers in comparison to those of healthy control.In addition, all time domain parameters were significantly decreased from their corresponding baseline value just 5 minutes after smoking and returned close to their baseline value after 30 minutes of smoking but it remained significantly lower than control value. Conclusion: The result of this study concludes that cigarette smoking had acute effect on cardiac autonomic function causing depressed vagal activity and overbalance of sympathetic function..
Fasting Insulin in Essential Hypertension.
(2014-12) Sinha, Susmita; Akhter, Qazi Shamima; Akhter, Qazi Farzana; Tasnim, Masuma
Background: An association between essential hypertension and defective insulin secretion has been identified. Objective: To estimate fasting serum insulin level in adult male with essential hypertension to observe its relationship to hypertension. Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2012 to June 2013. A total number of one hundred fifty male subjects were selected with age ranging from 25 to 45 years. Seventy five male essential hypertensive were enrolled from Out- patient Department of Medicine, Dhaka Medical College Hospital, Dhaka. Age matched seventy five apparently healthy males were studied as control. Fasting serum insulin level was measured by ELISA method and fasting blood glucose by glucose oxidase method. For statistical analyses, unpaired Student’s ‘t’ and Pearson’s correlation coefficient (r) tests were performed. Results: Fasting serum insulin level was significantly (P<0.001) higher in essential hypertensive male patients than normotensive subjects. Fasting serum insulin level shows significant positive correlation with systolic blood pressure in hypertensive patients. Conclusion: This study reveals that essential hypertension has positive and significant relationship with fasting serum insulin level.
Effect of Peanut (Arachis Hypogaea L.) On Fasting Blood Glucose And Hba1c in Alloxan Induced Diabetic Male Rats.
(2014-12) Akter, Fatema; Jahan, Nasim; Sultana, Nayma
Background: Diabetes mellitus (DM) is a heterogeneous group of metabolic disorders with micro and macrovascular complications which are the major causes of morbidity and mortality in diabetic patients. Peanut due to its anti-oxidant property can reduce blood glucose level and may reduce the risk of diabetes. Objective: To observe the anti-diabetic effects of peanut (Arachis hypogaea L.) in alloxaninduced diabetic male rats. Method: This experimental study was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka in 2013. For this purpose, 15 wistar albino male rats, aged 90-120 days, weighing 160-200 g (initial body weight) were included in the experimental group (DG-A-P). Age and weight matched 20 wistar albino rats without peanut supplementation was taken as control and divided into (BC and DC-A) . All groups of animals received basal diet for 21 consecutive days. In addition to basal diet, animals of DC-A received alloxan intraperitoneally only on the first day of the study. Moreover, animals of DG-A-P also received peanut extract for 21 consecutive days. After 16 hours of fasting blood samples were collected from tail vein of all rats on day-1 and day- 3. After taking final body weight all the rats were sacrificed on 22nd day. Their pancreas was removed and weighed. To observe glycemic control serum blood glucose and blood HbA1c levels were measured by usual laboratory technique. ANOVA, independent t-test and paired t-test were used for statistical analysis. Result: The % change of body weight was significantly (p<0.001) lower in DC-A in comparison to that of BC. The weight of pancreas was significantly lower in DC-A (p<0.001) and DG-A-P (p<0.05) when compared to that BC, whereas this level was significantly higher (p<0.001) in DG-A-P than that of DC-A. The mean fasting blood glucose level on day-3 was significantly (p<0.001) higher in DC-A and DG-A-P in comparison to that of BC. Then this level was significantly (p<0.001) lower in DG-A-P in comparison to that of DC-A on day-22. Moreover, significantly higher levels of HbA1c were observed in DC-A (p<0.001) and DG-A-P (p<0.05) in comparison to those of BC. Again, significantly (p<0.001) lower level of blood HbA1c were observed in DG-A-P than those of DC-A. Conclusion: From this study, it can be concluded that peanut (Arachis hypogaea L.) has anti-diabetic effect by reducing fasting blood glucose, HbA1c levels. This anti-diabetic effect may be due to its high MUFA content and anti-oxidant property.
Neuro-Muscular Control of Coordinated and Effective Movements: Revisiting Modular Concepts in the CNS.
(2014-06) Mahato, Niladri Kumar
Neurophysiologic analysis of motor behavior has become one of the prime research areas in the domain of Physiology and hence it has seen tremendous development integrated research in this field over the years. This short review discusses the broad approaches which favors to understand effective neural control of motor behavior. The focus of this review is to recognize the gradual evolution of basic ideas regarding execution of coordinated and effective movements. The integrated roles of the spinal cord, the cerebellum and the motor cortex in context of voluntary movements have been delineated with citation of important research observations made in the field of motor control. Internet database related to human motor behavior studies were extensively searched to map the chronological development of important research methods and newer findings in this field. The span of the text ranges from the development of the idea of Motor Primitives to Brain-Machine Interfaces. It is observed that several ‘basic’ neural modules are preserved through ontogeny and phylogeny. Different combination of hierarchical modular functioning provides a wide range of plasticity required for coordinated and effective skillful movements.

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