Journal of Bangladesh Society of Physiologists

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https://imsear.searo.who.int/handle/123456789/149643

Editor: Professor Dr Shah Abdul Latif,

ISSN1995-1213; (Online)

Frequency: 2 issues a year

Language: English

Official Journal of the Bangladesh Society of Physiologist.

Open Access Peer-reviewed journal

Web site: https://www.banglajol.info/index.php/JBSP/

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Now showing 1 - 20 of 153

Acute Effect of Cigarette Smoking On HRV in Current Cigarette Smokers.
(2014-12) Ferdous, Mehboba; Ferdousi, Sultana
Background:Cigarette smoking induced increased sympathetic activity is one of the major independent risk factor for cardiac morbidity and mortality. Objective:To assess acute effects of smoking on neuro cardiovascular regulation by analysis of time domain measures of HRV in current regular healthy male cigarette smoker. Methods:This comparative analytical study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka from July 2011 to June 2012. 120 apparently healthy male current regular cigarette smoker aged 20-55 years were participated in the study group. Age and BMI matched 70 apparently healthy male non smoker subjects were studied as control. To observe the acute effects data were recorded 5 and 30 min after finishing a cigarette. Time domain measures of HRV were recorded by a RMS digital polyrite D. Statistical analysis was done by independent sample t test and paired sample t test.Results: Resting pulse rate, SBP, DBP, mean heart rate were significantly higher (p<0.001) and mean R-R interval, SDNN, RMSSD and total power were significantly lower (p<0.001) in all smokers in comparison to those of healthy control.In addition, all time domain parameters were significantly decreased from their corresponding baseline value just 5 minutes after smoking and returned close to their baseline value after 30 minutes of smoking but it remained significantly lower than control value. Conclusion: The result of this study concludes that cigarette smoking had acute effect on cardiac autonomic function causing depressed vagal activity and overbalance of sympathetic function..
Age Related Change in Thyroid Function.
(2012-12) Rahman, Shakila; Jahan, Nasim; Sultana, Nayma
Background: Thyroid hormones play a vital role in metabolism, sensitivity of tissues to other hormones and also in oxygen consumption of almost all cells of the body. However, mild to moderate decrease in function of thyroid gland may occur with advancing age even in apparently healthy elderly subjects. Objectives: To observe age related change in thyroid function status in apparently healthy elderly subjects in Bangladesh. Methods: This cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka between 1st January 2011 and 31st December 2011. Sixty apparently healthy elderly subjects of both sexes aged 50 to 75 years were taken as study group. They were collected from Probin Nibash Hitoishi Shangha, Agargaon, Dhaka. In addition, 30 apparently healthy young adult subjects aged 20-40 years were included as control. For assessment of thyroid function, serum free thyroxine (FT4), free triiodothyronine (FT3) and thyroid stimulating hormone (TSH) levels were estimated by ELISA method. Statistical analysis was done by one way ANOVA, Bonferroni test and Pearson’s Correlation Coefficient test as applicable. Results: In this study, mean serum free thyroxine (FT4) and free triiodothyronine (FT3) levels were significantly (p<0.001) lower and serum thyroid stimulating hormone (TSH) level was significantly (p<0.001) higher in apparently healthy elderly subjects in comparison to those of the healthy young subjects. Again, serum FT4 and FT3 levels were negatively correlated whereas serum TSH level was positively correlated with age of the subjects. Conclusion: The present study revealed a progressive decrease in thyroid function with advancement of age.
Allergen Skin Test Reactivity and Serum Total IgE Level in Adult Bronchial Asthmatic Patients.
(2009-06) Parveen, T; Begum, N; Begum, S
Background : Asthma affects more than 100 million people worldwide. Increased morbidity is multifactorial and may include increased exposure to indoor allergens and environmental pollutants, overuse of beta-2 agonist, underuse of anti-inflammatory mediators and limited education about health care. Allergy represents a specific alteration in biologic reactivity mediated by an immunologic mechanism and resulting in an adverse physiologic response. Objective : Some of the type of allergen’s sensitivity by skin prick test and serum total IgE level were studied in adult asthmatic patients to observe their relationships. Methods : This study was carried out in the department of Physiology, Bangabandhu Sheik Mujib Medical University, Dhaka and Asthma center,Mohakhali, Dhaka from January 2005 to December 2005. Allergen skin prick tests (SPT) were done by Pepy’s skin prick method and serum total IgE level by Enzyme Linked Immunosorbent Assay method on 30 asthmatic patients and 30 age and sex matched control subjects .Data were analyzed statistically by unpaired student’s ‘t’ test and Chi- squares test. Results: In this study, maximum numbers of asthmatic patients had positive SPT for dust mite which was followed by house dust and by cockroach. Frequency percentage for dust mite was significantly higher(P<0.05) than that of house dust and cockroach .It was also significantly higher in house dust than that of cockroach (P< 0.001). The mean serum total IgE level was significantly higher (P<0.001) in asthmatic adults compared to that of healthy subjects. . On the other hand, the association between the positive skin prick tests of all allergens used in this study and elevated serum total IgE were not statistically significant (P >0.05). Conclusion : Therefore , it can be concluded that different allergens like, house dust, dust mite and cockroach are responsible for bronchial asthma in our country which can be detected by SPT. Thus it can be used for identification of type of actual allergens responsible for bronchial asthma which may be a useful measure for earlier detection of allergens and for hyposensitization or desensitization of that patients accordingly with those allergens.
Anatomical Positions of Vermiform Appendix in Bangladeshi People.
(2006-12) Rahman, M M; Khalil, M; Rahman, H; Mannan, S; Sultana, S Z; Ahmed, S
The study was done to see the incidences of different anatomical positions of vermiform appendix in Bangladeshi people to increase the knowledge regarding variational anatomy in our population. A total 100 vermiform appendix (male-60, female-40) were observed in situ on cadaver of different age and sex during routine post mortem examination in the autopsy laboratory of Forensic Department of Mymensingh Medical College. This cross-sectional descriptive study was done by convenient sampling technique. For convenience of differentiating the incidences of different positions of vermiform appendix in relation to age and sex findings were classified and analyzed in four age groups (up to 20 year, 21 - 35 years, 36 - 55 years, 56 - 70 years) and in different sex. In the present study, the pelvic position of vermiform appendix was the most common position in all age groups and pelvic positions were found in 47% cases. The retrocaecal position was the second highest position (22%) and pre ileal position was the lowest (10%) in number. In respect to sex, incidences of pelvic variety of vermiform appendix were more in male than female.
Antinociceptive and Anti-inflammatory Effects of Combined Administration of a-tocopherol and Diclofenac.
(2015-06) Juaira, Tasneema; Begum, Noorzahan; Ali, Taskina
Background: Nonsteroidal anti-inflammatory drugs such as diclofenac are used for relief of pain and inflammation, but frequently cause gastrointestinal complications. This study aimed to explore that combination of diclofenac and α-tocopherol (αT) are better analgesic as well as anti-inflammatory agent than that of diclofenac alone. Objective: To assess the effects of combination of diclofenac with α-tocopherol on pain and inflammation. Methods: This prospective experimental study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka between January to December 2013. For this purpose, 15 male Long Evans rats were studied. On the basis of vitamin and drug administrations, the rats were divided into three (3) groups (5 rats in each). Control group received normal saline, one experimental group received diclofenac sodium (DS) at a dose of 10 mg/kg/body weight, and another experimental group received combination of DS with αT at a dose of 10 mg/kg/body weight and 500mg/kg/body weight, respectively. All the groups received single dose and equal volume (1 ml) through intraperitoneal route 1 hour before the test. Just one hour after administrations, they were subjected to formalin test followed by formalin induced paw edema test. The data were statistically analyzed by ANOVA followed by Bonferroni Post Hoc test. Results: Combined administration of DS and αT significantly (p<0.001) lowered the variables for nociceptive pain, central analgesic activity, inflammatory pain and inflammation than individual intervention of DS. Conclusion: From this study it may be concluded that, combined administration of diclofenac sodium and ±-tocopherol were more effective in lowering pain and inflammation than individual administration of diclofenac.
Assessment of Autonomic Nerve Function In Hypothyroids By Time Domain Method of Heart Rate Variability.
(2012-06) Ahmed, Matia; Begum, Noorzahan; Ferdousi, Sultana
Background: Cardiovascular complications are common in hypothyroids .Time domain measures of HRV is useful to determine the cardiac autonomic regulation by assessing sympathovagal balance. Objective: To assess the cardiac autonomic nerve function activity by time domain measures of heart rate variability in patients with hypothyroidism. Methods: This cross sectional study was carried out in the Department of Physiology, Banghabandhu Sheikh Mujib Medical University between July 2008 to June 2009 on 60 female patients with hypothyroidism aged 30-50 years. 30 age matched apparently healthy euthyroid subjects were also studied as control. Hypothyroid patients were divided into 2 subgroups ,one group includes patients on their 1st day of diagnosis, before starting of treatment and another group includes patients with medication for 12-18 months. The patients were selected from the Out Patients Department of Endocrinology Wing BSMMU. Serum TSH and FT4 levels of all subjects were measured by AxSYM system. For assessing HRV by time domain method, mean R-R interval, mean heart rate, SDNN, RMSSD and variance were measured by a Polyrite. For statistical analysis, Independent Sample t test and One Way ANOVA were used. Results: The mean serum TSH was significantly higher and FT4 was significantly lower (p<0.001) in newly diagnosed hypothyroids than those of control and treated group. In untreated hypothyroid patients the mean values of heart rate, SDNN , RMSSD,variance were found significantly (p<0.001) lower in comparison to both control and treated patients. No significant difference in these hormonal levels and all these time domain measures were found between control and treated group. Conclusion: This study concludes that decrease parasympathetic nerve activity may be a consequence of hypothyroidism, if not treated properly.
Assessment of Autonomic Nerve Function In Patients With Irritable Bowel Syndrome.
(2012-06) Nayem, Mohammad; Begum, Noorzahan; Ferdousi, Sultana
Background: Autonomic nerve function impairment is related to development of Irritable Bowel Syndrome (IBS). Heart rate variability (HRV) is a useful tool to measure autonomic nerve function activity and also sympatho-vagal balance. Objective: To assess autonomic nerve function activity by heart rate variability analysis in patients with Irritable Bowel Syndrome. Methods: This cross sectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from 1st July 2010 to 30th June 2011. Ninety patients aged 20-50 years of both sexes with Irritable bowel syndrome were included in the study group. They were enrolled from the OPD of Gastroenterology in BSMMU. For comparison age and sex matched 30 apparently healthy subjects were also studied as control. The power spectral HRV parameters were recorded by a digital Polyrite. For statistical analysis ANOVA, independent sample t-test were performed. Results: Mean resting pulse rate, mean HR, SBP, DBP, LF, LF norm and LF/HF were significantly higher(P<0.001) and total power, HF, HF norm were significantly lower(P<0.001) in IBS group compared to those of control. Conclusion: This study concludes markedly lower parasympathetic with concomitant higher sympathetic activity and shifting of sympathovagal balance towards sympathetic predominance in patients of IBS.
Assessment of Coagulation Disorder in Women Taking Oral Contraceptives.
(2014-06) Samsunnahar; Akhter, Qazi Shamima; Atiquzzaman; Akhter, Najneen; Begum, US Naima; Rahman, Farhana
Background: Oral contraceptive pill (OCP) is related to development of hypercoagulability and the risk of thromboembolic effects in women. Objectives: To assess the coagulability status in women taking oral contraceptives by estimation of plasma fibrinogen level and total count of platelets. Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, during the period of January 2012 to December 2012 on sixty apparently healthy female subjects aged 25 to 45 years taking OCPs for 1 to 10 years. Thirty subjects were 1 to 5 years user group and another 30 subjects were >5 to 10 years user group. They were collected from family planning clinics of Dhaka city. In addition, age matched 30 apparently healthy women of OCP nonusers were also studied as control. For assessment of coagulability state, plasma fibrinogen and total counts of platelet levels were estimated by automated coagulation analyzer and automated hematology analyzer. Statistical analysis was done by unpaired Student’s t’ test. Results: The mean (±SE) total count of platelet level was significantly higher (P<0.001) in contraceptive user group and plasma fibrinogen level was higher in users but it was not significant. Conclusion: This study concludes that OCP users had more tendency of hypercoagulability and therefore these women are at higher risk of thromboembolic effects.
Assessment of Colour Blindness and Erythrocyte G6PD Enzyme Status among the School Children of Dhaka City.
(2009-12) Yasmin, A; Jahan, N; Akhter, R
Background: Visual impairment due to colour blindness is an unusual suffering of the school children. It may be associated with erythrocyte G6PD enzyme deficiency. Objective: To find out defective vision due to colour blindness in apparently healthy school children and to measure erythrocyte G6PD enzyme level among them. Methods: This cross sectional study was carried out in the Department of Physiology, SSMC from 1st July 2007 to 31st June 2008. Five hundred (500) apparently healthy school children of old Dhaka, age ranged from 6 to 12 years irrespective of gender and race was selected as study population. Colour vision test was done by Ishihara’s test. Erythrocyte G6PD enzyme was measured among the colour blind children. All the results were compared to that of children with normal colour vision. Results: Five male children were detected to have partial red-green type of colour blindness. The percentage of colour blindness was statistically not significant (p>0.05) when compared to that of children with normal colour vision. Mean erythrocyte G6PD enzyme level of colour blind children was significantly lower (p<0.05) compared to that of children with normal colour vision. Presence of G6PD enzyme deficiency among the colour blind children did not show any clinical abnormalities might be due to different non symptomatic G6PD variants. Conclusion: Visual defect due to colour which blindness particularly red-green type might be present in apparently healthy school children associated with erythrocyte G6PD enzyme deficiency.
Assessment of Percentage Saturation of Hemoglobin with Oxygen in Arterial Blood of Pregnant Women.
(2006-12) Sunyal, D K; Amin, M R; Molla, M H; Ahmed, A; Ferdousi, S; Khatun, F
Objective: Percentage saturation of hemoglobin with oxygen in arterial blood (SaO2) was studied in pregnant women to evaluate the lung function status in pregnancy. Methods: This study was conducted in the department of physiology in Dhaka medical college during July 2004 to June 2005. For this purpose total 32 women with age ranged 25-35 years without any recent history of respiratory diseases were selected from Dhaka city. Eight (8) age matched apparently healthy women was taken as control and Twenty four (24) normal pregnant women without any complication were included in experimental group. All pregnant subjects were studied during first, second and third trimester. SaO2 was determined by “Easy Blood Gas Auto Analyzer”. SaO2 during different trimesters were compared with that of non pregnant and also among the trimesters. Statistical analysis was done by students unpaired ‘t’ test. Result: Mean ±SD SaO2 during first trimester (97.73%±0.92), second trimester (98.05%±0.54) and third trimester (98.40%±0.30) were progressively increasing and were significantly higher (p<0.05, p<0.001, p<0.001) than that of non pregnant women (96.71±0.63). But no statistically significant differences were observed among the trimesteric values. The present result indicates increased lung function in pregnant women associated with progressively increased oxygen saturation with trimester. Higher progesterone level is related to increased ventilation which is more marked in luteal phase of menstrual cycle. In pregnant women gradually rising progesterone level reaches its peak at the later part of pregnancy. Conclusion: Therefore it may be concluded from the present study that progressively increased SaO2 might be related to hyperventilation induced by high progesterone level.
Assessment of Some Aspects of Cardiovascular Function Status in Male Patients with Stable COPD.
(2013-12) Pervin, Magfura; Begum, Noorzahan; Ali, Taskina
Background: COPD is a preventable and treatable disease with some important extra pulmonary effects, which may contribute to the severity of this disease. Among these extra pulmonary ailments cardiovascular disorders are noteworthy. Although its silent involvement is known, but little attention paid to this major comorbidity while treating COPD patients. Objective: to assess rate, systolic blood pressure (SBP) and peak systolic velocity (PSV) of blood flow to observe the cardiovascular function status in stable COPD patients Methods: This cross-sectional study was carried out in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka during 2010. For this purpose 60 (sixty) male, smoker (5 to 10 pack years) patients of stable COPD (FEV1/FVC% <0.70; FEV1 e” 80%; without any exacerbation for last 4 weeks) were randomly selected from the Out Patient Department of the Department of Cardiology, BSMMU and also from a private clinic in Dhaka city. On the basis of spirometric findings, 30 mild (group B1) and 30 moderate stage (group B2) of COPD patients with age 35-45 years were included in the study. In addition, 30 age and BMI matched apparently healthy male persons were studied as control (group A). For assessment of cardiovascular function, pulse rate, SBP and PSV were measured. PSV of blood flow in distal part of the right brachial artery in arm was measured by Color Doppler ultrasonography. For statistical analysis, Independent sample t-test and Pearson’s Correlation Coefficient test were used. Results: Significantly (p<0.001) higher mean pulse rate and SBP were observed in moderate stage of COPD patients than those of control and mild stage. PSV was significantly (p<0.001) higher in both stages than those of the control as well as in moderate stage to that of the mild COPD. In addition, SBP and PSV were negatively correlated with FEV1 in moderate stage which was statistically significant (p<0.01). Conclusion: This study suggests that, cardiovascular status may be altered in stable COPD and this alteration is inversely related to the severity of the disease.
Association Between ABO Blood Groups And Myocardial Infarction In Jodhpur City of India.
(2012-06) Garg, Priyanka; Kumar, Jayant; Choudhary, Raghuveer; Chawla, VK
Background: Many reports have appeared in recent years showing an association between blood groups and Myocardial Infarction. Clinical studies have shown a significant association between MI and blood group B. Objective: To investigate correlation of ABO blood groups with risk of MI. Methods: The present cross sectional study analyzed ABO blood group among total 400 subjects of any age from the local population of Jodhpur city from July to December 2011.Among them 200 subjects were normal healthy(135 male and 65 female) students of Dr. S.N. Medical College, Jodhpur and another 200(135male, 65female) were MI patients admitted in the CCU of Mathura Das Memorial(MDM) Hospital, Jodhpur. ABO blood group of all subjects were determined by slide agglutination method. Risk of MI was expressed by risk ratio. Data were analyzed by one sample chi square test. Results: The results obtained in this study showed that the prevalence of MI in blood group B is significantly higher than in all other ABO blood groups. Conclusion: The results may conclude that there is a significant association between MI and blood group B. So this study reveals MI risk is associated with the blood group B.
Autonomic Dysfunction in Current Cigarette Smokers Assessed by Time Series Analysis of Heart Rate Variability.
(2013-12) Ferdouse, Mehboba; Ferdousi, Sultana
Autonomic Dysfunction in Major Depressive Disorder.
(2014-06) Jahan, Choudhury Rifat; Begum, Shelina; Ferdousi, Sultana; Uddin, Md Moyeen
Background: Cardiovascular (CV) morbidity is a major problem in patients suffering from depression as greater CV mortality is found in cardiac patients with depression. Objective: To assess cardiac autonomic nerve activity by power spectral analysis of heart rate variability in patients with Major Depressive disorder. Methods: This case control study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka during 2011. Sixty patients of both sexes with Major Depressive disorder (MDD) aged 20-50 years were enrolled. The patients were selected from the Department of Psychiatry in Bangabandhu Sheik Mujib Medical University (BSMMU). Thirty drug naive MDD patients and thirty medicated MDD patients were compared with 30 healthy control and also between them. The HRV parameters were recorded by 4 active channels, RMS Polyrite-D. For statistical analysis independent sample t-test test was used. Results: LF norm and LF/HF were significantly higher and Total power, HF power, HF norm were significantly lower in both drug naive and medicated MDD patients in comparison with those of healthy control. Conclusion: Autonomic nerve dysfunction involved both the drug naive and medicated MDD patients which was associated with higher sympathetic activity and reduced vagal modulation of the heart and sympathovagal imbalance. Antidepressent drug treatment did not have any effect on autonomic dysfunction.
Autonomic Neuropathy in Healthy Elderly Person.
(2013-12) Islam, Taslima; Begum, Noorzahan; Ferdousi, Sultana
Background: Cardiac autonomic nerve function can be affected in older age. Objective: To find out the degree of autonomic neuropathy by autonomic nerve function scoring system in apparently healthy elderly subjects. Methods: This cross sectional study was conducted in the Department of Physiology, BSMMU, Dhaka between July 2005 and June 2006.For study group, 30 elderly subjects age ranged from 51-60 years were enrolled in one group whereas another 30 elderly subjects age between 61-70 years were enrolled in another group. For comparison sex and BMI matched thirty apparently healthy adults with age from 21-30 years were studied as control. Autonomic nerve function status of all the subjects were examined by five simple non-invasive cardiovascular reflex tests Valsalva maneuver deep breathing test, orthostatic test handgrip test, and sudden standing. Autonomic nerve function (ANF) scoring was done to find out the degree of autonomic neuropathy. Results: 23.34% of subjects of 61-70 years group showed autonomic nerve dysfunctions and 20% had early involvement and 3.34% of them had definite involvement of Autonomic neuropathy. But this percentage was relatively less (10%) in 51-60 years who had early involvement and none had found definite involvement whereas autonomic nerve function was normal in 21-30 years age group.. Conclusion: From this study, it can be concluded that aging process substantially impaired cardiovascular autonomic nerve function.
Autonomic Neuropathy in Obesity.
(2011-06) Akhter, Shahin; Begum, Noorzahan; Ferdousi, Sultana; Khan, M D Sakhawat Mahmud
Beneficial Effect Associated with Use of Watery and Alcoholic Extract of Garlic as a Supplement in Hyperlipidemic Guniea Pigs.
(2011-06) Choudhary, Kamla; Choudhary, Raghuveer; Choudhary, Prema Ram; Chawla, V K
Background: Garlic is naturally occurring sulphur containing dietary agent belong to Allium family. Members of this family i.e. Garlic, Onions are found to have beneficial effect on atherosclerosis and ischemic heart diseases in both experimental animals and in human beings. Objective: To compare the potency of garlic as antihyperlipidemic and antiplatelet and antithrombotic between its watery and alcoholic extract for their effects. Methods: 25 guinea pigs were fed cholesterol (0.5g/kg body weight) for an initial period of 4 weeks. Cholesterol was then discontinued and the animals were divided into 3 groups. Group-I (n=7) was fed with stock diet and was taken as control. Group-II (n=9) was given 1ml of watery extract and Group-III (n=9) was fed with 1ml of alcoholic extract of garlic with normal diet daily for 4 weeks. The garlic content of both the extract was 2 gm/ml by wt/vol. Fasting blood samples were collected at the end 4 weeks and finally at the end of the study i.e.8 weeks for estimation of serum cholesterol, serum triglyceride, LDC-C, HDL-C, VLDL-C,atherogenic index and platelet adhesiveness index. Bleeding time and clotting time were also detected in all the 3 groups.Results: In the present study, the watery and alcoholic extract of garlic shows significant hypolipidemic activity as they reduced significantly serum cholesterol, serum triglyceride, LDC-C, VLDL-C and atheriogenic index in hyperlipidemic guinea pigs (p<0.01) compared to control. The significant rise in HDL-C was observed in group II but not in group III animals. On comparison between two extracts, watery extract of garlic was more potent hypolipidemic agent, compared to alcoholic extract. Both extract significantly reduces platelet adhesiveness and bleeding time. But between two extract the watery extract was found more potent anti-thrombotic agent as it showed significant decrease in platelet adhesiveness (P<0.01). BT was significantly increased in group II compared to group I and III. Conclusion: It can be concluded that watery extract of Allium Sativum is more potent hypolipidemic and antiplatelet, and anti-thrombotic agent.
Cadaveric Study of The Anatomical Variations of The Accessory Pancreatic Duct.
(2014-12) Shahriah, Sunjida; Nurunnabi, Abu Sadat Mohammad; Johora, Fatema; Siddiqua, Dilruba; Ara, Shamim
Background: The accessory pancreatic duct enters the duodenum at the minor duodenal papilla, developmentally draining the dorsal pancreatic bud; however, it is smaller and less constant than the main pancreatic duct and undergoes varying degrees of atrophy at the duodenal end. Objective: The objective of this study was to see the variations in course, opening and communication pattern of the accessory pancreatic duct in different age-groups in a Bangladeshi population. Methods: This crosssectional, descriptive study was done was done in the Department of Anatomy, Dhaka Medical College, Dhaka, from August 2005 to December 2006, based on collection and dissection of 75 postmortem male human pancreas. The collected samples were divided into seven age groups: 10-19 years, 20-29 years,30-39 years, 40-49 years, 50-59 years),60-69 years and(eˆ70 years. However, 65 samples were taken for final observation. Results: The accessory pancreatic duct was found in 27.69% specimens. Straight course was found in 50% specimen, while spindle course in 27.78% and cudgel course in 22.22% specimens were observed. In only 4 (6.15%) specimens, the accessory pancreatic duct communicates with the common bile duct, while in 11 (16.93%) specimens, the accessory pancreatic duct communicates with the main pancreatic duct. 12 (66.67%) accessory pancreatic ducts opened into the minor duodenal papilla, while 5 (27.78%) into the major duodenal papilla and 1 (5.55%) into the 3rd duodenal papilla. Conclusion: Several variations were observed in accessory pancreatic duct pattern in terms of their course, opening and communications. However, no significant differences were evident in any parameter among the age groups. Here, females were excluded due to less availability of the female cadaveric pancreas during study period.
Calcium And Zinc Deficiency In Preeclamptic Women.
(2011-12) Akhtar, Selina; Begum, Shelina; Ferdousi, Sultana
Background: Pre-eclampsia is the most common medical complication of pregnancy associated with increased maternal and infant mortality and morbidity. Reduced serum calcium and zinc levels are found associated with elevated blood pressure in preeclampsia. Objective: To observe serum calcium and zinc levels in preeclamptic women. Methods: This cross sectional study was carried out in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka between July 2009 to June 2010. In this study, 60 pregnant women of preeclampsia, aged 18-39 years with gestational period more than 20th weeks were included as the study (group B). For comparison age and gestational period matched 30 normotensive pregnant women control (group A) were also studied. All the subjects were selected from Obstetric and Gynae In and Out patient Department of BSMMU and Dhaka Medical College Hospital. Serum calcium was measured by Colorimetric method and serum zinc was measured by Spectrophotometric method. Data were analysed by independent sample t test and Pearson’s correlation coefficient test. Results: Mean serum calcium and zinc levels were significantly (p<0.001) lower in study group than those of control group. Again, serum calcium and zinc showed significant negative correlation with SBP and DBP in preeclamptic women. Conclusion: This study concludes that serum calcium and zinc deficiency may be one of the risk factor of preeclampsia. Therefore, early detection and supplementation to treat this deficiency may reduce the incidence of preeclampsia.
Central Research Labs In Medical Colleges.
(2011-12) John, Nitin Ashok

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