Antinociceptive and Anti-inflammatory Effects of Combined Administration of a-tocopherol and Diclofenac.
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Date
2015-06
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Abstract
Background: Nonsteroidal anti-inflammatory drugs such as diclofenac are used for relief of pain and
inflammation, but frequently cause gastrointestinal complications. This study aimed to explore that
combination of diclofenac and α-tocopherol (αT) are better analgesic as well as anti-inflammatory
agent than that of diclofenac alone. Objective: To assess the effects of combination of diclofenac with
α-tocopherol on pain and inflammation. Methods: This prospective experimental study was conducted
in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag,
Dhaka between January to December 2013. For this purpose, 15 male Long Evans rats were studied.
On the basis of vitamin and drug administrations, the rats were divided into three (3) groups (5 rats in
each). Control group received normal saline, one experimental group received diclofenac sodium (DS)
at a dose of 10 mg/kg/body weight, and another experimental group received combination of DS with
αT at a dose of 10 mg/kg/body weight and 500mg/kg/body weight, respectively. All the groups
received single dose and equal volume (1 ml) through intraperitoneal route 1 hour before the test. Just
one hour after administrations, they were subjected to formalin test followed by formalin induced paw
edema test. The data were statistically analyzed by ANOVA followed by Bonferroni Post Hoc test.
Results: Combined administration of DS and αT significantly (p<0.001) lowered the variables for
nociceptive pain, central analgesic activity, inflammatory pain and inflammation than individual
intervention of DS. Conclusion: From this study it may be concluded that, combined administration of
diclofenac sodium and ±-tocopherol were more effective in lowering pain and inflammation than
individual administration of diclofenac.
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Keywords
Pain, analgesic, diclofenac, α-tocopherol, formalin test, inflammation, paw edema
Citation
Juaira Tasneema, Begum Noorzahan, Ali Taskina. Antinociceptive and Anti-inflammatory Effects of Combined Administration of a-tocopherol and Diclofenac. Journal of Bangladesh Society of Physiologists. 2015 June; 10(1): 30-35.