Assessment of Some Aspects of Cardiovascular Function Status in Male Patients with Stable COPD.
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Date
2013-12
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Abstract
Background: COPD is a preventable and treatable disease with some important extra pulmonary
effects, which may contribute to the severity of this disease. Among these extra pulmonary ailments
cardiovascular disorders are noteworthy. Although its silent involvement is known, but little attention
paid to this major comorbidity while treating COPD patients. Objective: to assess rate, systolic blood
pressure (SBP) and peak systolic velocity (PSV) of blood flow to observe the cardiovascular function
status in stable COPD patients Methods: This cross-sectional study was carried out in the Department
of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka during 2010. For
this purpose 60 (sixty) male, smoker (5 to 10 pack years) patients of stable COPD (FEV1/FVC% <0.70;
FEV1 e” 80%; without any exacerbation for last 4 weeks) were randomly selected from the Out Patient
Department of the Department of Cardiology, BSMMU and also from a private clinic in Dhaka city. On
the basis of spirometric findings, 30 mild (group B1) and 30 moderate stage (group B2) of COPD
patients with age 35-45 years were included in the study. In addition, 30 age and BMI matched
apparently healthy male persons were studied as control (group A). For assessment of cardiovascular
function, pulse rate, SBP and PSV were measured. PSV of blood flow in distal part of the right brachial
artery in arm was measured by Color Doppler ultrasonography. For statistical analysis, Independent
sample t-test and Pearson’s Correlation Coefficient test were used. Results: Significantly (p<0.001)
higher mean pulse rate and SBP were observed in moderate stage of COPD patients than those of
control and mild stage. PSV was significantly (p<0.001) higher in both stages than those of the control
as well as in moderate stage to that of the mild COPD. In addition, SBP and PSV were negatively
correlated with FEV1 in moderate stage which was statistically significant (p<0.01). Conclusion: This
study suggests that, cardiovascular status may be altered in stable COPD and this alteration is
inversely related to the severity of the disease.
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Keywords
PSV, blood flow, cardiovascular function status, COPD
Citation
Pervin Magfura, Begum Noorzahan, Ali Taskina. Assessment of Some Aspects of Cardiovascular Function Status in Male Patients with Stable COPD. Journal of Bangladesh Society of Physiologists. 2013 Dec; 8(2): 51-57.