Allergen Skin Test Reactivity and Serum Total IgE Level in Adult Bronchial Asthmatic Patients.
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Date
2009-06
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Abstract
Background : Asthma affects more than 100 million people worldwide. Increased morbidity is
multifactorial and may include increased exposure to indoor allergens and environmental
pollutants, overuse of beta-2 agonist, underuse of anti-inflammatory mediators and limited
education about health care. Allergy represents a specific alteration in biologic reactivity
mediated by an immunologic mechanism and resulting in an adverse physiologic response.
Objective : Some of the type of allergen’s sensitivity by skin prick test and serum total IgE level
were studied in adult asthmatic patients to observe their relationships. Methods : This study was
carried out in the department of Physiology, Bangabandhu Sheik Mujib Medical University, Dhaka
and Asthma center,Mohakhali, Dhaka from January 2005 to December 2005. Allergen skin prick tests
(SPT) were done by Pepy’s skin prick method and serum total IgE level by Enzyme Linked
Immunosorbent Assay method on 30 asthmatic patients and 30 age and sex matched control subjects
.Data were analyzed statistically by unpaired student’s ‘t’ test and Chi- squares test. Results: In
this study, maximum numbers of asthmatic patients had positive SPT for dust mite which was followed
by house dust and by cockroach. Frequency percentage for dust mite was significantly higher(P<0.05)
than that of house dust and cockroach .It was also significantly higher in house dust than that of
cockroach (P< 0.001). The mean serum total IgE level was significantly higher (P<0.001) in asthmatic
adults compared to that of healthy subjects. . On the other hand, the association between the positive
skin prick tests of all allergens used in this study and elevated serum total IgE were not statistically
significant (P >0.05). Conclusion : Therefore , it can be concluded that different allergens like, house
dust, dust mite and cockroach are responsible for bronchial asthma in our country which can be
detected by SPT. Thus it can be used for identification of type of actual allergens responsible for
bronchial asthma which may be a useful measure for earlier detection of allergens and for
hyposensitization or desensitization of that patients accordingly with those allergens.
Description
Keywords
Allergen, Ige, Bronchial asthma
Citation
Parveen T, Begum N, Begum S. Allergen Skin Test Reactivity and Serum Total IgE Level in Adult Bronchial Asthmatic Patients. Journal of Bangladesh Society of Physiologists. 2009 June; 4(1): 1-6.