Insulin Secretory Status in Obese Female.
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Date
2014-12
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Abstract
Background: In obesity insulin hypersecretion is a key feature indicating the abnormal pancreatic
beta cell function which is the fundamental defect in the development of NIDDM, hypertension and
cardiovascular diseases. Objective: To assess the secretory status of insulin in adult obese female.
Methods: The present study was a cross sectional analytical study and conducted in the Department
of Physiology, Dhaka Medical College, Dhaka from July 2012 to June 2013. 50 obese female subjects
of 20-40 years were included from Out-patient Department (Obesity clinic) of BIRDEM Hospital,
Dhaka and by personal contact from different areas of Dhaka city. 50 age matched, healthy non-obese
female subjects selected as controls . Fasting serum insulin level was measured by ELISA and fasting
glucose level was measured by Glucose oxidase method. The insulin secretory status was calculated
by HOMA-%B using HOMA software. For statistical analysis unpaired Student’s ‘t’ test and Pearson’s
correlation coefficient (r) test were performed as applicable . Result: Mean fasting serum insulin and
HOMA%B (P<0.001) were higher in the obese than that non obese. Fasting serum insulin level and
HOMA%B showed significantly positive correlation with WHR. Conclusion: This study concludes
that obese individual develops a state of insulin hypersecretion and hyperinsulinemia.
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Keywords
Obesity, HOMA-%B, Hyperinsulinemia
Citation
Tasnim Masuma, Akhter Qazi Shamima, Akhter Salma, lovely Nasreen Sultana, Begum Khadiza, Sinha Susmita. Insulin Secretory Status in Obese Female. Journal of Bangladesh Society of Physiologists. 2014 Dec; 9(2): 72-77.