International Journal of Clinical and Biomedical Research (IJCBR)

Editor-in-Chief: Dr. Bharatha Ambadasu
ISSN: 2395-0471

Frequency: Quarterly

Language: English

Open Access Peer-reviewed journal

Web site:


Recent Submissions

Now showing 1 - 20 of 201
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    Assessment Of Serum Lipid Profile In Hypertensive Patients: A Case-control Study
    (Sumathi Publications, 2020-01) V, Sushma Reddy; TV, Hari Prasad; B V, Surendra
    Background: Hypertension and dyslipidemia are strongly associated with each other, and they are the most common risk factors for the development of the cardiovascular disease. Aim:Compare the serum lipid profile values among hypertensive patients and non-hypertensive individuals. Method:30 patients with Hypertension and 30 age-matched non-hypertensive controls were included in the study. From the serum, total cholesterol levels were estimated by enzymatic (CHOD-PAP) colorimetric method, triglyceride by enzymatic (GPO-PAP) method, HDL-cholesterol and LDL-cholesterol were estimated using precipitant and Friedewald formula, by using commercially available reagent kits. Lipid profiles were compared with controls. Results:The mean values of total cholesterol were significantly more in Hypertensives-202.93 ± 28.44 and normotensives-178.76 ± 37.21, P<0.006. The mean values of triglycer-ides were significantly more in Hypertensives-139.8 ± 18.72 and normotensives-125.8± 12.34, P<0.001. The mean values of LDL-Cholesterol were significantly more in Hypertensives-141.63 ± 11.59 and normotensives-127.83 ± 14.65, P<0.0001. Conclusions:As Dyslipidemia is associated with Hypertension, serum lipid profile may be useful in the identification of patients at risk of Hypertension. Hypertensive patients need the measurement of blood pres-sure and lipid profile at regular intervals to prevent Cardiovascular diseases.
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    Role Of Multi-slice Spiral Ct In Evaluation Of Neck Mass With Cytological Correlation
    (Sumathi Publications, 2020-01) Das, Runa; Ghosh, Aniruddha
    The swellings in the neck can be caused by innumerable pathological lesions arising from the various ana-tomical structures lying therein. Multi-Detector CT (MDCT) has now become the new standard in a radiological imag-ing modality. The utilization of MDCT has resulted in improved resolution and considerable reductions in scan acqui-sition and display time. Aim and Objective:This study is an effort to assess the role of MDCT in detection, charac-terization and diagnosing neck pathologies that correlate cytologically. Methods: A study of 50 cases in a clinically suspected neck mass was studied. Contrast-enhanced CT neck was done, and Specific CT criteria were used to charac-terize the mass so that a probable diagnosis could be made. MDCT diagnoses then compared with cytological results to conclude efficiency of MDCT analysis of neck mass. Results:In our study, the correlation between MDCT diagno-sis and pathological diagnosis was significant (p<0.001) when we compare both the modalities for diagnosing malig-nancy. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy is 92.3%, 87.5%, 88.9%,91.3%, 90% respectively. Conclusion:Multi-detector computed tomography helps in precise anatomical local-izationandcharacterizationofneckmasses.Hence,itwillbeamethodofchoiceforinitialevaluation,preoperativeplanning, and biopsy targeting and postoperative follow-up
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    Correlation Of Lower Limb Strength, Power, Waist-hip Ratio And Bmi With A Sitting-rising Test In 18-35 Years Age Group
    (Sumathi Publications, 2020-01) Gotmare, Neha; Narang, Simran; Chandra, Ruchi; Deshpande, Maneesha
    Purpose: To investigate the co-relation of sitting-rising test scores with measures of lower extremity strength, power, and body compositions (body mass index and waist-hip ratio). Furthermore, to find out the level of physical activity in the targeted population. Methods: Participants aged between 18-35 years (n=131) of both genders were recruited in this study. Along with performing sitting-rising test, anthropometric and demographic data were collected to calculate body mass index and waist-hip ratio. Lower extremity strength was assessed using a 30-second chair stand test, and power was assessed using a triple hop test for distance. Also, the Rapid Assessment Disuse Index questionnaire was given to dividing the population into two groups depending on whether they are involved more in physical activity or not. Results: Sitting-rising test scores showed a positive correlation with lower extremity strength and power, negative correlation with body mass index, and no co-relation with waist-hip ratio. Further, 76 participants out of 131 were less physical activity and had more sedentary behavior. Conclusion: Sitting-rising from the floor in young adults is influ-enced by the strength and power of lower extremities and body mass index except for the waist-hip ratio
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    Microbiological Screening Of Otorrhoea From People Coming To Hospital In Mahajanga
    (Sumathi Publications, 2020-01) Rivo, Rakotomalala; patrick, Randrianandraina; tsiriniaina, Ramavoson; fiacre, Ramisarimanana; ainamalala, Catherine Razafindrakoto; tahirimalala, Rabenandrianina; Davidra, Rajaonatahiana; odilon, Tiandaza; olivat, Rakoto Alson; andry, Rasamindrakotroka; rasoamialy, Razanakolona
    Background: Otorrhoea commonly hits young people. Ciprofloxacin and rifampicin are the two ear drop antibiotics commonly used for the probabilistic treatmentof otitis in Madagascar. This study aimedto determine the potentially dangerous bacteria involved in otitis and to identify their resistance to fluoroquinolone or rifampicin. Method: A pro-spective study was conducted with the collaboration ofthe Ear Nose and Throat unit (ENT) at the laboratory of UHC PZaGa in Mahajanga. In whole, 56 patients were included. Samplings of otorrhoeawere performed by aspirating the auditory canal using 2ml sterile syringeand then were headed to thelaboratory in less than 30 minutes for analysis. Results:Amidst identified microorganisms were fungus (4,7%) and bacteria (95,3%) to which Gram-negative bacilli represented72.1% (n=44), Gram-positive cocci 6.4% (n=10), Gram-positive bacilli 8.2% (n=5) and Gram-negative cocci 3.3% (n=2). Amongthese bacterias, Pseudomonas aeruginosa and Proteus sp were predominant, with respec-tively 41% (n=25), 23% (n=14). However,three casesof S. aureusreported six with negative coagulaseStaphylococ-cus, one with Escherichia coli, one with Klebsiella sp, one with Haemophilus sp, two cases with Neisseria sp and four cases with Corynebacterium sp. Two types of cultures were noticed, one of them monomorphic (91.1%, n=51) and the other polymorphic (8.9%, n=5) to which three associations of P. aeruginosa-Proteus sp, 1 association of P. aerugino-sa-coagulase-negative Staphylococcus and one association of P. aeruginosa-E. coli. No resistance to ciprofloxacin was observed with Pseudomonas, Neisseria sp, Haemophilus, and enterobacteria except for E. coli. No resistance to rifampicin was observed with S. aureus. However, the sensitivity of S. aureus to ciprofloxacin decreased(one bacte-rium out of three). Conclusion:The use of rifampicin or fluoroquinolones should be based on the type of ear infec-tions. Rifampicin is suggested only if S. aureuswas responsible for otitis. Ciprofloxacin use is still yet sensible to Gram-negative bacilli.
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    Vacuum And Thermoplastic Mould-based Immobilization Systems Used In Patient Undergoing Pelvic Radiation Therapy: A Comparative Study
    (Sumathi Publications, 2020-01) Virkar, Mayuresh; Kumar, N Arul; Chadha, Pranav; Rodrigues, Reuben Jake; Kharde, Anup
    Introduction: The aim of the present study was to compare two immobilization systems for comparison of setup errors in targeted radiotherapy. Methods: Retrospective analysis was done for the patients undergoing radiotherapy from May 2012 to December 2018 at our institution. Immobilization was performed on 30 patients sessions (Vacuum cushion i.e., Vac-Lok™ = 15; Thermoplastic mould i.e., Pelvicast pelvic masks = 15). A total of 763 cone-beams were analysed. The target lesion location was verified by cone-beam computed tomography (CBCT) prior to each session, with displacements assessed by CBCT simulation prior to each treatment session. Systematic setup errors, random setup errors, isocenter deviations in the Medio-lateral (ML), Supero-inferior (SI), Antero-posterior (AP), Rotation (yaw) directions of the patient position was calculated. Results: On comparing the Vac-Lok™ and Pelvicast pelvic masks group with respect to Systematic and random error in the lateral, longitudinal, vertical and YAW direction, no statistically significant difference was seen except the random error in YAW direction (P=0.037, Unpaired t-test). There was no difference observed in comparing the isocentric deviation. Conclusion: It was inferred and concluded that using a vacuum cushion for pelvic radiotherapy provides no added benefit compared to using a thermoplastic mould. Thermoplastic mould is recommended for patients receiving pelvic radiotherapy to improve overall reproducibility
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    Association Between Serum Uric Acid And Hba1c In Patients With Type 2 Diabetes Mellitus: A Case Control Study In Indian Population
    (Sumathi Publications, 2020-01) Verma, Indu; Nimesh, Archana
    Background and Aim:Uric acid is a pro-oxidant molecule that might be implicated in increasing oxidative stress and insulin resistance in type 2 diabetes mellitus patients. Hence, the aim of the study was to assess serum uric acid and HbA1clevel (an indicator of glycemic control) in these patients and speculate the association between the two. Meth-ods:40 newly diagnosed cases of Type 2 diabetes mellitus (20 males and 20 females) with age ranging between 35-70 years were statistically compared against 40 age and sex-matched healthy subjects with respect to their uric acid and HbA1c levels. Demographic data like the height and weight of patients was also recorded and statistically compared. Results:No statistical difference in age, height and weight were observed in type 2 diabetes cases vs. controls indicat-ing that the groups were comparable. HbA1c and uric acid levels of males and females with type 2 diabetes mellitus were significantly higher in comparison to normal males and females (controls). Correlation analysis showed a posi-tive and significant correlation between HbA1c and uric acid levels in male and female cases of type 2 diabetes melli-tus. Conclusion:Uric acid might have a role in the development or worsening of type 2 diabetes mellitus. However, further studies are required with a larger sample size to clearly establish the relationship between uric acid and glyce-mic control in type 2 diabetes mellitus since studies in the literature have shown conflicting results and hence the un-derstanding of the etiopathogenesis of type 2 diabetes mellitus remains poorly understood with respect to uric acid
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    Seroprevalence Of Hiv, Hepatitis B And C And Syphilis Among Men Having Sex With Men In Mahajanga (magadascar)
    (Sumathi Publications, 2020-01) Riana, Rakotondrazaka H.; Rivo, Rakotomalala; Cathérine, Razafindrakoto A.; Tsiry, Ramavoson; Tahirimalala, Rabenandrianina; Davidra, Rajaonatahiana; Ralison, Fidiarivony; Rakoto, Alson A. Olivat; Razanakolona, L. Rasoamialy; Rasamindrakotroka, Andry; Randriamanantany, Z Arivelo
    Sexually transmitted diseases (STD) are public health concerns worldwide. The aim of our study is to assess infection and coinfection with HIV, hepatitis B, hepatitis C and syphilis among men having sex with men in Mahajanga which is a western coastal town of Madagascar. We conducted a prospective and descriptive preliminary study in the laboratory of the University Hospital Center PZAGA in Mahajanga during a period of three months, from December 2014 to February 2015. We included 100 MSM in our study. Their mean age was 36 yrs (16 to 55 yrs). We found 30% of seropositive men among our sample. HIV positive men are mainly part of the age group [20–29 yrs]. The mean age of positive men was respectively 38 yrs., 36 yrs., 48 yrs.and 39 yrs. for HIV, for HBV, HCV, and syphilis. We found respectively for hepatitis B, hepatitis C and syphilis 7%, 1% and 11% positive samples. We found no co-infection HIV and HCV for them. But we found 5% of coinfection HIV-HBV, 4% of coinfection HIV-syphilis and 1% of coinfection of HIV, HBV and syphilis. We highlighted a very high rate of HIV positivity among MSM living in Mahajanga. Efforts have to be made in order to sensitize them about risky behaviors.
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    Prevalence Of Tobacco Consumption Among Adolescents From Rural Area Of Wardha District
    (Sumathi Publications, 2019-01) Kumar, Vishnoi Ravindra; Wagh, Vasant; Gaidhane, Abhay; Pramita, Muntode; Prajapati, Kshatrapal
    Background-Globally adolescent population is around 1200 million and out of six person, every one person is in ado-lescence (aged10 to 19 years) period. Yet most of them are healthy, but premature death, illness and injury among them can hinder ability to grow and develop to their full potential. It is estimated that 1.2 million adolescents died in 2015 and mostly from preventable or treatable causes. Tobacco consumption is world’s leading cause of preventable morbidity and mortality. National Family Health Survey conducted in year 2016-17 reported tobacco consumption prevalence 38.9% in urban area and 48% in rural area of India. Method-It was a community based cross-sectional study conducted in eight villages of Wardha district adopted under Community Health Care program run by depart-ment of community medicine. Data was collected by interview from 485 adolescent in the age group of 10-19 years by domiciliary visits using pre-designed pre-tested questionnaire. Results:Prevalence of tobacco use (all forms), smoke-less tobacco use and smoking in rural adolescents were 20.82%, 20.41%, and 2.68%, respectively. Prevalence of to-bacco use in boys (30.29%) was more than girls (4.49%). Higher Prevalence was found in late adolescent period. Bidi was commonly used form of smoke tobacco while Kharra was the preferred smokeless tobacco. Almost all smokers were male but few exceptions were there. Conclusion: The prevalence of tobacco use among rural adolescents was very high (20.82%) as compared to national prevalence of 14.6% according to the global youth tobacco survey India 2009. There is a need of early intervention for tobacco cessation as overall mean age of 1st experienced to tobacco consumption was 12.02 years and in male and female users it was 12.25 years and 10.88 years respectively. 42.10 % adolescents 1st time experienced any type of tobacco products when they were in the 12-14 years age and only 0.66% adolescents experienced at the age of 17 -19 years. Maximum male (42.19%) and female (41.67%) ever user experi-enced their 1st tobacco consumption when they were 12-14 years old.
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    Perceptions Of Women About Breast Cancer In Rural Area Of Wardha District
    (Sumathi Publications, 2019-01) N, Gondnale Goral; Ingole, Abhishek; Mudey, Abhay; Kshatrapal, Prajapati
    Background:The incidence of breast cancer is seen to be low in India as compared to western countries, however the mortality is low. The knowledge about breast cancer, breast awareness and self-breast examination is the need of the hour. Breast Cancer, if caught in the early stages, makes it curable by various modalities of treatment. Our study aims here to qualitatively explore the views and ideas of the women in rural area about breast cancer and the need of a bet-ter comprehensive program. Method: A community based cross-sectional study was carried out with a sample size of 672 with a pre-tested questionnaire with open-ended questions for qualitative exploration. It was done by door-to-door survey. Resident females of the village above 30years were included and females with chronic illness and temporary residents were excluded. Results:The mean age of participants was 42.38±9.76 years with 48.2% educated till sec-ondary school and 83.2% belonged to OBC category. The perceptions were assessed with qualitative findings where it was found that most of the females believed that they don’t have breast cancer even before getting screened and so they didn’t want to get mammography. However they affirmed that a doorstep approach of activities would be benefi-cial. They also said that doorstep activities help get good information of breast cancer signs and symptoms and pro-gram like this will be a good approach. Conclusion: Doorstep approach can be a welcome change in imparting aware-ness
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    Efficacy, Tolerability And Safety Of Intravenous Iron Sucrose In Postpartum Anaemia
    (Sumathi Publications, 2019-01) Rajput, Rucha; Podey, Ashish; Baheti, Tushar; Bangal, V B; Deshpande, Sarita
    Background:Anemia is one of major contributing factor in maternal mortality and morbidity in third world countries and according to the WHO, contributes to 40% maternal deaths. Postpartum anemia is observed in up to 27% of wom-en.It is a common problem throughout the world. Treatment of postpartum iron deficiency anemia includes oral and parenteral iron supplmentaion as well as blood transfusion in severe cases. Methods: This was a prospective longitudi-nal study carried out in Department of Obstetrics & Gynaecology of PRH, Loni. Total 80 women suffering from post-partum anemia of age above 18 years with haemoglobin (HB) level below 11gm/dl and above 6gm/dl were included for the study. After history taking, clinical examination and baseline Hb level, all of them were administered intrave-nous iron sucrose 200 mg per dose per day till the total calculated dose was administered. The post therapy evaluation was done with the estimation of Hb on day 1, day 7, day 14 and day 21. Results:31.25% women belonged to the age group each of 19-21 years and 22-24 years. Maximum number of patients received 3 doses of IV Iron sucrose (i.e. total 600mg) followed by 2 doses (i.e. total 400mg), 4 doses (i.e. total 800mg) and 5 doses (i.e. total 1000mg) respec-tively. Hb level rises extremely significantly (p<0.001) after IV Iron Sucrose administration on day 1, 7, 14 & 21 as compared to corresponding values before delivery as analyzed by Friedman Test (Nonparametric Repeated Measures ANOVA) . 16 patients (20%) experienced thrombophlebitis to IV Iron Sucrose administration. About 12 (15%) pa-tients experienced rigor followed by sweating in 10 patients (12.5%) and fever in 8 patients (10%). About 62 patients (77.5%) from total 80 reported well tolerability to IV Iron Sucrose while remaining 18 patients (22.5%) reported poor tolerability to IV Iron Sucrose Conclusion:Intravenous iron sucrose increases the haemoglobin more rapidly in first week as compared to second and third week in women with postpartum iron deficiency anemia. Hypersensitivity reac-tion, chest pain, dyspnoea reported with iron dextran and iron sorbitol citric acid were not observed with iron sucrose. Intravenous iron sucrose can be used safely to fill a rift between blood transfusion and oral iron in treatment of post-partum iron deficiency anemia.
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    In Silico Design Of Potential 1,5-benzothiazepine Derivatives As An Anti- Convulsant Agent By Molecular Docking Studies
    (Sumathi Publications, 2019-07) Parjane, Smita; Kunkulol, Rahul; Dattatray, Nandal
    Epilepsy is characterized by the presence of recurrent seizures. A seizure can be defined as “an episodic disturbance of movement, feeling, or consciousness caused by sudden synchronous, inappropriate, and excessive electrical discharges in the cerebral cortex”. One in every three patients with epilepsy is probable to be severely disabled. It is continuing this scenario as an attempt to develop potent and nontoxic anti-convulsant agents. Recently discovery of benzothiazepine derivatives as an anticonvulsant agent is significant area for research in medicinal chemistry as it is free from all side effects which is shown by a developed as an anticonvulsant agent. In this paper, we have presented results of 2D, and 3D docking poses studies of a series of 300 (Three series) molecules containing 1,5-benzothiazepine pharmacophore as anti-convulsant agents. Docking analysis was utilized to predict the mechanism of action of the designed derivatives for anticonvulsant potential. All the molecules exhibited binding score in the range of -82.61 to -118.25 kcal/mol. Most active molecules from Series 1, 2 and 3 exhibited hydrogen bond interactions with LEU282B, LEU282B and LEU282B. Also for the selected standard sodium phenytoin showed the hydrogen bond interaction with LYS637A. It was noted that the docking score of 1a to 10a, 101b to 110b and 201c to 210c was almost same as that of selected standard sodium phenytoin. Protein showed hydrogen bonding with all synthesized compound showed potential against the epilepsy with GABA nergic mechanism.
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    Awareness And Effect Of Janani Suraksha Yojana On Antenatal Care And Institutional Deliveries In Rural, Urban & Tribal Areas Of Ahmednagar District.
    (Sumathi Publications, 2019-01) Dhakne, Swathi; Phalke, Deepak
    Janani Suraksha Yojana (JSY) is a centrally sponsored scheme which is being implemented with the objective of re-ducing maternal and infant mortality by promoting institutional delivery among pregnant women. The Government of India introduced the JSY (safe motherhood program) based on the principles of CCT. Under JSY, cash assistance was given to pregnant women receiving at least three antenatal check-ups (ANCs) and delivering at institutions. The study is undertaken to establish if there is any co-relation of level of awareness about the scheme and its impact on ANC and institutional deliveries in the rural, urban and tribal area of Ahmednagar district. Method: The JSY beneficiaries were asked demographic characteristics, area of residency, educational levels, Category and place of delivery were noted. A set of question (self-designed and pretested) and their responses were noted. Result: Out of 825 JSY beneficiaries, there were total 781 (94.7%) Hindu, Muslim 23(2.8%) and Christian 21 (2.5%) beneficiaries. Majority of Hindu reli-gion JSY beneficiaries. Only few member from BPL JSY beneficiaries have opted for delivery at private hospital. Maximum deliveries taking place in civil hospital are from BPL category. It was observed that the awareness level about JSY is low in tribal area compared to the rural and urban area. It was also seen that 648 (78.54%) JSY benefi-ciaries availed free transport facility out of which 358 (55.24%) fall in high level of awareness category. There is a positive relation between age group and awareness about JSY. Conclusion: 46.8% women with high awareness about JSY scheme, it is a programme for pregnant women which aims at safe institutional delivery. Other factors such as education of mother, religion, culture, area of residence, family type played important role in utilization of available maternal health scheme.
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    Parental Perception Of Low Iq Facts Or Fiction: Retrospective Data From Clinic In Semi Rural Maharashtra
    (Sumathi Publications, 2019-10) Tamboli, Suchit Suresh; Joglekar, Charudatt; Desle, Vasant; Tamboli, Anvesh
    Objective: To study the association between physical and psychological problems perceived by parents and the IQ of their children. Methods: We studied 981 children in the child development center at Ahmednagar. Median age at followup was 7.8y (Q25=5.6y and Q75=10.4y, Babies underwent IQ evaluation by Binet Kamat scale (n=981); also their physical and psychological problems perceived by parents were documented. We categorized children into 4 categories using number of problems (physical and psychological separately) viz 1 (no problem), 2 (1 problem), 3 (2 problems), 4 (>2 problems). When we looked at physical problem data, 555 (56.6%) had no problem, 251 (25.6%) had 1, 117 (11.9%) had 2, and remaining 58 (5.9%) had more than 2. For psychological problems like not interested in studies, speech problems don't remember, don't understand, cannot concentrate, fears, etc. The distribution was 221 (22.5%), 212 (21.6%), 222 (22.6%) and 326 (33.3%) respectively. Result: The increasing trend of mean IQ for physical problem parameters from nil to >2 categories and decreasing prevalence of low IQ using Binet Kamat scale were not significant. However, for psychological problems the decreasing and statistically significant trend (p=0.000) was present for mean IQ, and a significant increasing trend (p=0.029) for prevalence of low IQ was observed. Conclusion: Psychological problems were associated with IQ. Numbers of problems were inversely correlated with IQ.
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    Clinico-microbiological Profile Of Infective Keratitis In A Tertiary Care Hospital, Eastern India
    (Sumathi Publications, 2019-10) Paty, Bimoch Projna; Maitreyi, Tadepalli; Sanghamitra, Padhi; Banojini, Parida
    Background: Infective Keratitis (Microbial Keratitis) is infection of the cornea caused by a wide spectrum of micro-bial agents. Its main clinical presentation is Corneal ulcer that is defined as a loss of corneal epithelium. According to World health organization (WHO), corneal diseases are among the major causes of vision loss and blindness in the world today, second only to cataract in overall importance. Aim:To isolate and identify the pathogenic organism Method:The study was conducted in 45 patients diagnosed with corneal ulcer attending Ophthalmology OPD, MKCG Medical College and Hospital, Berhampur over a period of 2 months. The material was scraped from the lead-ing edge and base of the ulcer and was inoculated onto Blood agar, Mac conkey agar and Sabouraud Dextrose agar for culture and onto 2 slides for Gram’s stain and 10% KOH wet mount. The susceptibility testing was done by Kirby Bauer’s disc diffusion method. Results: Out of total 45 patients,35were males. Majority of the patients belonged to age group of 50-60 years. Pain, Redness, Hypopyon was most commonly seen in Bacterial keratitis. In Fungal Keratitis, Redness (80%), Blurred vision (80%) was seen. Most common occupation was Farmers (66.6%). Trauma was the most common risk factor (23 isolates). Majority were bacterial isolates (29 isolates,64.4%) followed by fungal (5 iso-lates ,11.1%). Predominant isolate was Staphylococcus aureus(68.9%). All the gram-positive isolates showed 100%senitivity to Linezolid and Vancomycin. Conclusion: Knowledge of local prevalence of etiological agents of IK and their susceptibility patterns helps in guiding ophthalmologists to select appropriate antibiotic for empirical therapy
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    Sublingual Vitamin D3 Drug Therapy In Vitamin D Deficiency Patients At Pravara Rural Hospital
    (Sumathi Publications, 2019-10) T, Sanjeeva Kumar Goud; Kunkulol, Rahul
    The present study was aimed to study the effect of Sublingual Vitamin D3on Serum Vitamin D level in Vitamin D deficiency patients. This was a cross-sectional and interventional study. All the Vitamin D deficiency patients of age 18-60years and either gender, willing to participate in the study were included. Patients who had greater than 20 ng/ml were excluded from the study. The total number of participants in our study was 200, out of these 111 males and 89 females, the mean age in our study was 51.07 ± 7.39Yrs. All volunteers were given sublingual vitamin D3 (60,000IU) in six doses every fifteen days of follow up for 3 months. The subject’s serum 25(OH)D levels were estimated before and after treatment of sublingual vitamin D3. There was statistically significant difference in serum vitamin D3 level before 16.61±6.71 ng/ml and after 35.80±7.80 ng/ml after treatment with Sublingual Vitamin D3. Six doses of 60,000IU of Vitamin D3sublingual route having improved role of serum 25(OH)D levels in treatment of Vitamin D3deficiency patients
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    Impact Of Mccd Workshop On Knowledge And Awareness In Post Graduate Residents At A Tertiary Care Teaching Hospital
    (Sumathi Publications, 2019-01) Kadu, Sandeep S; Khalkar, Atul A
    Background: Medical Certificate of Cause of Death is a vital document, important scientific tool issued by the doc-tors. It is the physician’s primary responsibility to complete the medical certificate of cause of death correctly. Incor-rect filling up of the certificate will result in gross errors in legal scrutiny in medico-legal deaths. Method:At the beginning the self-designed, pretested questionnaire open ended was distributed to participants, immediately after dis-tribution pre-test was conducted. After the pre-test an interactive workshop was conducted on theMCCD. After the workshop post test was conducted. Result:There was an increase in the knowledge about who issues death certifi-cates, long form of MCCD, who issues death certificate, maximum period within which you have to inform the regis-trar office about death in your clinic/hospital, detent dead body until your bills paid, what matter you are going to write on 1a. column and version present available in medical students from 0% to 61%, 30% to 100 %, 0% to 91 %, 0% to 91 %, 70 % to 96 %, 26 % to 87 % and 39 % to 100 % respectively. Conclusion:In the present study there is an improvement in knowledge and awareness in post graduates students after an interactive workshop on theMCCD.
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    Determination Of White Blood Cells Using Foldscope With Smartphone
    (Sumathi Publications, 2019-10) Kumar, Ranu; Prasad, Kapildeo
    We have traditionally used Microscope in a clinical laboratory for the determination of white blood cells of human blood smear. Now, in this study we were used Foldscope with Smartphone in the place of Microscope and examine many samples of human blood smear which was collected from local diagnostic centers. We were very quickly quanti-ty & morphology analysis of all types of WBC cells such as Neutrophils, Lymphocytes, Monocytes, Eosinophils, Ba-sophils in blood smear with the help of Foldscope & image taken by Smartphone. The main objective of this study is to use Foldscopefor quantity & morphology analysis of human WBCs at field level especially poor resource area where healthcare services or centers is not available & where carry of microscope is not possible.
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    Hematological Profile And Serum Potassium Level In Patients Of Chronic Renal Failure At A Tertiary Health Care Center
    (Sumathi Publications, 2019-10) Yogi, Jai Prakash; Fiza, Bushra; Godara, Suraj; Sinha, Maheep
    Background: Chronic Kidney Disease (CKD) can be defined as an estimated glomerular Filtration Rate (eGFR) of less than 60 ml/min/1.73 m2for a minimum period of three months. CKD is commonly associated with various hema-tological abnormalities especially anemia. Aim: The present study was planned to assess the hematological variations in CKD patients as compared to healthy subjects. Method: Fifty patients diagnosed with CKD were enrolled for the study. Fifty age and sex-matched healthy subjects constituted the control group. Blood samples were collected for all subjects enrolled in the study and subjected to analysis including complete blood count (CBC) using five parts cell counter and renal function test (RFT), including urea, creatinine using dry chemistry, and potassium using direct ion-selective electrode method. Result: On comparison of the hematological profile, it was observed that all enrolled CKD patients were anemic with hemoglobin (Hb) less than 13g/dL in males and less than 12 g/dL in females. The mean Hb levels were as low as 7.50 ± 1.55 g/dL (P< 0.0001). Correspondingly, total RBC count of CKD patients was also low. It was also observed that platelet count was slightly low among CKD patients. However, the mean level was compara-ble with control group (P=NS). On further analysis, it was observed that among fifty CKD patients, 46% (n=23) suf-fered from severe anemia i.e. Hb < 7 gm/dL, whereas 48% had moderate anemia i.e. Hb between 7-9.9 gm/dL. How-ever, only 12 % (n=6) CKD patients suffered from thrombocytopenia i.e. platelets count < 1.50 lack/cmm. Conclu-sion: Hematological abnormalities may lead to several associated morbidities and may pose a challenge for mainte-nance of overall health status for CKD patients. Hence, there is need to monitor hematological profile of CKD patients specially those on dialysis so that any abnormality can be detected and managed accordingly.
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    Analysis Of Pesticide Poisoning Cases In A Tertiary Care Hospital, Mumbai.
    (Sumathi Publications, 2019-01) Karat, Rajesh D; Kedare, Rahul
    Background: Acute pesticide poisoning (APP) is a serious problem worldwide. Pesticide poisoning is a common meth-od of suicide attempt and less commonly accidental poisoning in India. Methods: A prospective analysis of pesticide poisoning cases admitted to the emergency department of tertiary care, teaching hospital. The data regarding socio-demographic profile, pattern of poisoning, Occupation, type of pesticide poisoning, relation of pesticide poisoning and risk factors, time of ingestion of pesticide poisoning and Seasonal variation were studied. Results: Of 174 cases admit-ted to the emergency department of hospital with a diagnosis of acute pesticide poisoning, the most cases observed in the age group 21-30 years (n: 72, 41.37%). Total males affected were 94 (54.02%) dominating the females 80 (45.98%) and male to female ratio (1.17:1). But in younger age group, females were more affected than males. The maximum cases belonged to the lower socioeconomic class (n: 82, 47.12%) and urban areas (n: 106, 60.91%). Majori-ty of the victims married and belonged to Hindu religion (n: 140, 80.4%). The suicidal was commonest manner of pes-ticide poisoning accounting 98 cases (56.32%). The occurrence of pesticide poisoning was more frequent in the even-ing (n: 82, 47.12%) and during the, monsoon (73, 41.95%). Conclusion: Pesticide poisoning is responsible for great number of admissions and deaths in India. There is a need for adequate guidelines for sale, use, storage and safety practices for the pesticide. These will be helpful for the enhancement of the knowledge, awareness and safety practices among the population for prevention and reduction of the pesticide poisoning. It also emphasized on the early availa-bility of treatment in the poisoning cases
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    Drug Utilization Pattern For Skin Diseases In Dermatology Opd At Tertiary Care Hospital Of Western Maharashtra
    (Sumathi Publications, 2019-07) Vakade, Kiran P; Indurkar, Vishal A; Chordia, Aayush H
    Background: Periodic auditing of prescriptions in terms of drug utilization study is an important tool to enhance the efficacy of the treatment, to decrease the risk of the adverse effects, to give cost-effective treatment and to provide useful feedback to the clinician. Prevalence of dermatological diseases is very high throughout the world, and in day to day practice, a quarter of the cases are related with dermatological manifestations. In studies conducted in the Out Pa-tient Department (OPD) of dermatology in North Palestine and Western Nepal, irrationalities in the prescriptions have been reported. Aim: To study the drug utilization pattern for skin diseases in dermatology OPD at tertiary care hospi-tal of Western Maharashtra. Methodology: The retrospective analysis of dermatology OPD records of 6 months (1stMarch 2018-31stAugust 2018) was carried out during the study period (1stSeptember 2018 to 30thNovember 2018). The proforma for collecting data was designed. Demographic details, diagnosis and treatment given for each patient were recorded. The data collected was condensed, and the master chart was prepared for data analysis. Result: During the study period, a total of 3869 patient’s case records were studied and analysed. A maximum number of patients (26.5%) found in the age group 31-40 years, followed by 23.5% of patients in the age group 21-30 years. Fungal in-fection was found in 39.6 % of patients followed by acne in 14.2% patients and eczema in 9.1% of patients. Drugs most commonly prescribed were antihistaminics (45.02%) followed by antifungal (39.6%) and steroids (27.8%). Levocetirizine (74.07%) and hydroxyzine (16.5%) were the most commonly prescribed antihistaminics. Itraconazole (58.17%) and Griseofulvin (24.67%) were the most commonly used oral antifungal drugs. Miconazole (73.73%) was the most commonly used topical antifungal drug, followed by ketoconazole (12.45%). Among steroids, prednisone (52%) and betamethasone (38.05%) were the most commonly used steroids by oral route while clobetasol (68.09%) and mometasone (19.5%) were the most commonly used steroids by topical route. Our study revealed that the per-centage of drugs prescribed from the WHO essential drug list was only 23.87%. Drugs which prescribed by the gener-ic names were less than <1%. Conclusion:Treatment protocols used in the management of skin disorders were near to the standard guidelines.