International Journal of Clinical and Biomedical Research (IJCBR)

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https://imsear.searo.who.int/handle/123456789/170455

Editor-in-Chief: Dr. Bharatha Ambadasu
ISSN: 2395-0471

Frequency: Quarterly

Language: English

Open Access Peer-reviewed journal

Web site: https://www.ijcbr.com/

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Now showing 1 - 20 of 208

Comparative Study of Immediate and Short Term Effect of 4 Days of Scapular Stabilizing Exercises and Scapular Proprioceptive Neuromuscular Facilitation on Scapular Alignment and Functional Task in Patients with Stroke – An Experimental Study
(Sumathi Publications, 2023-12) Bhagat, Prachi; Harishchandre, Maheshwari; Ganvir, Suvarna
Background: Stroke is the commonest neurological cause of morbidity and mortality all over the world. Alterations in scapular position and motion occur in 68–100% of patients due to changes in the tone of the upper extremity and reduced strength, leading to an altered position of the scapula. Scapular stabilizing exercises and Scapular PNF have been shown to be effective individually in improving scapular control. However, its effect on functional tasks and objective measurement has not been studied. So, the purpose of the study is to compare these two techniques to identify the better technique with respect to objective measurement and its effect on functional tasks. Methodology: An Experimental study was done in a tertiary care hospital on 18 patients according to inclusion criteria and was divided into two groups. Group A Scapular Stabilizing Exercises and Group B Scapular Proprioceptive Neuromuscular Facilitation and Intervention were given for four days, and pre and post-assessment were done by Palpation meter (PALM) and Functional tasks (lifting and lowering the cup). Results: The results showed significant improvement in both techniques, i.e., there is a decrease in the Total Height discrepancy (t = 3.4) (p 0.003) and the time taken for lifting and lowering the cup (t = 2.2) (p 0.04). Conclusion: Scapula Proprioceptive Neuromuscular Facilitation Exercises are more effective than Scapula Stabilizing Exercises and have a better short-term effect on Scapular Alignment and Functional Tasks in patients with Stroke.
Aflatoxins: An Innocent Cause of Lethality in Humans
(Sumathi Publications, 2023-12) Mohammad, Salim; Shafikun, Nisha; Mohammad, Shahid, Masroor; Shagufta, Parween
According to Food and Agriculture Organization, United Nations, approximately one-fourth of the world’s food crops are continuously being contaminated comprehensively by mycotoxins. More than 300 types of mycotoxins are produced by one-fourth of the cereal crops infected. The foodstuffs containing aflatoxins are indiscriminately being consumed by people developing various ailments, diseases and even cancer innocently. Aflatoxins (Afs) have been the most widely studied mycotoxin worldwide.The disease caused by the ingestion of aflatoxins is collectively called aflatoxicosis. They are mostly found in peanuts, mouldy maize grains, rice and perishable dairy products. There are four major types of aflatoxins (AFB1, AFB2, AFG1 and AFG2) found in nature mainly produced by the Aspergillus flavus, A. parasiticus and A. nomius. Aflatoxin B1 has always been a potent carcinogen classified by the WHO in Group “A” as causing cancer in humans. It induces mutation in the p53 gene to develop hepatocellular carcinoma (HCC) in humans. This is the third leading cause of cancer deaths worldwide. Keeping view in mind the present paper is an attempt to review the research done so far in the field of aflatoxins in humans. The review focuses on occurrence, epidemiology, historical glimpses, chemical nature and the types of aflatoxins, detection and detoxification, diagnosis, clinical symptoms and the treatment of aflatoxicosis in humans.
A Study of Sympathetic Skin Response inpersons with Type-2 Diabetes Mellitus
(Sumathi Publications, 2024-03) R. Ravindran; Iyer Saraswati; Deshpande Mangala
Background: Impairment in Autonomic nervous system constitutes to one of the most serious and important complications in persons with Diabetes. Noninvasive Sympathetic Skin Response (SSR) test assesses the impairment of the sympathetic fibers of the peripheral nerves is widely used and valid markers of autonomic neuropathy. Considering the cost effectiveness of these tests, SSR testing would help us in understanding the prevalence of autonomic dysfunction in patients with Type 2 Diabetes Mellitus (T2DM). Method: 30 adults diagnosed with T2DM and 25 normal healthy adults who volunteered to participate were assessed for SSR in their foot and hand. SSR was assessed using Neurowerk EMG/NCV equipment capable of assessing SSR. Electrical current was used on the median nerve at the wrist to elicit SSR. Results: SSR was elicited in all participants. In persons with T2DM, mean SSR latency and SSR Amplitude for the hand were 1.587 ± 0.759 secs and 1499 ± 1411 microVolt respectively. The mean SSR Latency and SSR Amplitude for the foot were 2.478 ± 1.247 secs and 39.2 ± 901.07 micro Volts respectively. Characteristics of the SSR curves were discussed. Conclusion: In persons with T2DM, mean SSR latency of hand and foot were 1.587 ± 0.759 and 2.478 ± 1.247 seconds respectively. Mean SSR amplitude of hand and foot were 1499 ± 1411 and 939.2 ± 901.07 microVolts respectively. Mean values SSR Latency & Amplitude of persons with T2DM were significantly different from that of normal healthy adult.
High Sugar Foods Addiction is Like a Slow Poison
(Sumathi Publications, 2023-09) Chatterjee, Bandana
Sugar is an ingredient that almost everyone craves. The reason behind it is that it is sweet in nature and ultimately makes things taste better. Nowadays, people try to reduce sugar in their diets to lead healthy and disease-free life. But unfortunately, due to their current lifestyle, everyone is not able to follow it. At times, cutting down sugar drastically can have major side effects, so it needs to be done slowly by diet.
Sericin A Boon to Medical and Dentaldoctors – A Review
(Sumathi Publications, 2023-09) Devi, Devarathnamma MV; Bhat, Geeta; Kudva, Praveen
Silk sericin is a natural polymer produced by the silkworm, Bombyx mori, which surroundsand keeps together two fibroin filaments in silk thread used in the cocoon. The recovery andreuse of sericin usually discarded by the textile industry not only minimizes environmentalissues but also has a high scientific and commercial value. The physicochemical properties ofthe molecule are responsible for numerous applications in biomedicine and are influenced bytheextractionmethodandsilkwormlineage,whichcanleadtovariationsinmolecularweightand amino acid concentration of sericin. The presence of highly hydrophobic amino acids andtheir antioxidant potential make it possible for sericin to be applied in the food and cosmeticindustry.Themoisturizingpowerallowsindicationsasatherapeuticagentforwoundhealing,stimulatingcellproliferation,protectionagainstultravioletradiation,andformulatingcreamsandshampoos.Theantioxidantactivityassociatedwiththelowdigestibilityofsericinexpandsthe application in the medical field, such as antitumour, antimicrobial and anti-inflammatoryagent,andanticoagulant,actsincolonhealth,improvingconstipationandprotectingthebodyfromobesitythroughimprovedplasmalipidprofile.Inaddition,thepropertiesofsericinallowits application as a culture medium and cryopreservation, in tissue engineering and for drugdelivery, demonstrating its effective use, as an important biomaterial. The present review onsericin describes its properties and application in various fields
The Role of Sympathetic Skin Response in Assessing Autonomic Function in Normal Adults
(Sumathi Publications, 2023-03) R. Ravindran; Iyer Saraswati; Deshpande Mangala
Background:Sympathetic Skin Response (SSR) is a simple, non-invasive and reproducibletest to assess the impairment of the sympathetic fibers of the peripheral nerves. It measuresthe change in electrical skin potential to a variety of stimuli. The objective of this study was toassess SSR in a sample of normal healthy adults.Method:25 normal healthy adults whovolunteered to participate were assessed for SSR in their foot and hand. SSR was assessedusing Neurowerk EMG/NCV equipment capable of assessing SSR. Electrical current was usedon the median nerve at the wrist to elicit SSR.Results:SSR was elicited in all 25participants. The mean SSR latency and SSR Amplitude for the hand were 1.2 (+/- 0.42) secsand 2503 (+/- 1424) micro Volt respectively. The mean SSR Latency and SSR Amplitude forthe foot were 1.8 (+/- 0.44) secs and 1749 (+/- 1252) micro Volts respectively. It was observedthat there was no significant difference in the SSR values when compared between male andfemale participants, so gender had no effect on SSR values. There was no association of SSRvalues with the BMI of the participants. Characteristics of the SSR curves were discussed.Conclusion:Mean values of SSR latency measured at hand and foot are 1.2 (+/- 0.42) secsand 1.8 (+/- 0.44) secs respectively. Mean values of SSR amplitude measured at hand and footare 2503 (+/- 1424) micro Volts and 1749 (+/- 1252) micro Volts respectively. Gender had noeffect on SSR values in this study.
Exploring the Therapeutic Potential of Moringa Oleifera in Lead Poisoning: An Investigation of its Effects on Blood Lead Levels and Oxidative Stress in Rats
(Sumathi Publications, 2023-06) Ejike, Onah Christian; Florence, Onah Chinwemma; Friday, Ehiaghe Alfred; thanasius, Onyegbule Onyema; Chukwuemeka, Ogbodo Emmanuel; Ukamaka, Ijeomah Ann; Micheal, Olisah Chinedu; Serah, Nnaemeka Wuraola; Chukwuemeka, Meludu Samuel; Emmanuel, Dioka Chudi
Objective: Lead poisoning is a global public health problem that has beenassociated with poor treatment outcomes. We therefore evaluated the ability of Moringa oleifera (M. oleifera) to reduce blood lead levels (BLL) and lead-induced oxidative stress related to dimercaptosuccinic acid (DMSA) in albino Wister rats. Methods: Thirty rats were assigned to five groups each consisting of six rats. The control group (A) received normal rat chow and water ad libitum for 12 weeks. Group (B-E) initially received 100-mg/kg body weight of lead acetate orally for 6 weeks. Thereafter, groups B, C, D, and E received DMSA and various doses of M. oleifera and their combination for an additional 6 weeks. Blood samples were taken before treatment, 6 and 12 weeks after treatment for analysis of BLL, malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD) and glutathione-s-transferase (GST). Results: BLL and MDA increased significantly (p<0.05), while serum SOD, CAT and GST activities decreased significantly (p<0.05) from their pretreatment valuesafter 6 weeks of lead-acetate administration. However, administration of 400-mg/kg body weight M. oleifera at 12 weeks posttreatment significantly (p<0.05) reduced 6-week BLL by(40.5%); MDA (52%); and significantly (p<0.05) increased the activities of serum SOD by (35%); CAT (26.3%); andGST (53%). Conclusion: M. oleifera was observed not only to be effective in lowering blood lead levels, but also toalleviate lead-induced oxidative stress through enhanced antioxidant activities. M. oleifera may therefore serve asan alternativetherapeutic approach to lead poisoning, particularly in resource-constrained settings.
Assessment Of Serum Lipid Profile In Hypertensive Patients: A Case-control Study
(Sumathi Publications, 2020-01) V, Sushma Reddy; TV, Hari Prasad; B V, Surendra
Background: Hypertension and dyslipidemia are strongly associated with each other, and they are the most common risk factors for the development of the cardiovascular disease. Aim:Compare the serum lipid profile values among hypertensive patients and non-hypertensive individuals. Method:30 patients with Hypertension and 30 age-matched non-hypertensive controls were included in the study. From the serum, total cholesterol levels were estimated by enzymatic (CHOD-PAP) colorimetric method, triglyceride by enzymatic (GPO-PAP) method, HDL-cholesterol and LDL-cholesterol were estimated using precipitant and Friedewald formula, by using commercially available reagent kits. Lipid profiles were compared with controls. Results:The mean values of total cholesterol were significantly more in Hypertensives-202.93 ± 28.44 and normotensives-178.76 ± 37.21, P<0.006. The mean values of triglycer-ides were significantly more in Hypertensives-139.8 ± 18.72 and normotensives-125.8± 12.34, P<0.001. The mean values of LDL-Cholesterol were significantly more in Hypertensives-141.63 ± 11.59 and normotensives-127.83 ± 14.65, P<0.0001. Conclusions:As Dyslipidemia is associated with Hypertension, serum lipid profile may be useful in the identification of patients at risk of Hypertension. Hypertensive patients need the measurement of blood pres-sure and lipid profile at regular intervals to prevent Cardiovascular diseases.
Role Of Multi-slice Spiral Ct In Evaluation Of Neck Mass With Cytological Correlation
(Sumathi Publications, 2020-01) Das, Runa; Ghosh, Aniruddha
The swellings in the neck can be caused by innumerable pathological lesions arising from the various ana-tomical structures lying therein. Multi-Detector CT (MDCT) has now become the new standard in a radiological imag-ing modality. The utilization of MDCT has resulted in improved resolution and considerable reductions in scan acqui-sition and display time. Aim and Objective:This study is an effort to assess the role of MDCT in detection, charac-terization and diagnosing neck pathologies that correlate cytologically. Methods: A study of 50 cases in a clinically suspected neck mass was studied. Contrast-enhanced CT neck was done, and Specific CT criteria were used to charac-terize the mass so that a probable diagnosis could be made. MDCT diagnoses then compared with cytological results to conclude efficiency of MDCT analysis of neck mass. Results:In our study, the correlation between MDCT diagno-sis and pathological diagnosis was significant (p<0.001) when we compare both the modalities for diagnosing malig-nancy. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy is 92.3%, 87.5%, 88.9%,91.3%, 90% respectively. Conclusion:Multi-detector computed tomography helps in precise anatomical local-izationandcharacterizationofneckmasses.Hence,itwillbeamethodofchoiceforinitialevaluation,preoperativeplanning, and biopsy targeting and postoperative follow-up
Correlation Of Lower Limb Strength, Power, Waist-hip Ratio And Bmi With A Sitting-rising Test In 18-35 Years Age Group
(Sumathi Publications, 2020-01) Gotmare, Neha; Narang, Simran; Chandra, Ruchi; Deshpande, Maneesha
Purpose: To investigate the co-relation of sitting-rising test scores with measures of lower extremity strength, power, and body compositions (body mass index and waist-hip ratio). Furthermore, to find out the level of physical activity in the targeted population. Methods: Participants aged between 18-35 years (n=131) of both genders were recruited in this study. Along with performing sitting-rising test, anthropometric and demographic data were collected to calculate body mass index and waist-hip ratio. Lower extremity strength was assessed using a 30-second chair stand test, and power was assessed using a triple hop test for distance. Also, the Rapid Assessment Disuse Index questionnaire was given to dividing the population into two groups depending on whether they are involved more in physical activity or not. Results: Sitting-rising test scores showed a positive correlation with lower extremity strength and power, negative correlation with body mass index, and no co-relation with waist-hip ratio. Further, 76 participants out of 131 were less physical activity and had more sedentary behavior. Conclusion: Sitting-rising from the floor in young adults is influ-enced by the strength and power of lower extremities and body mass index except for the waist-hip ratio
Microbiological Screening Of Otorrhoea From People Coming To Hospital In Mahajanga
(Sumathi Publications, 2020-01) Rivo, Rakotomalala; patrick, Randrianandraina; tsiriniaina, Ramavoson; fiacre, Ramisarimanana; ainamalala, Catherine Razafindrakoto; tahirimalala, Rabenandrianina; Davidra, Rajaonatahiana; odilon, Tiandaza; olivat, Rakoto Alson; andry, Rasamindrakotroka; rasoamialy, Razanakolona
Background: Otorrhoea commonly hits young people. Ciprofloxacin and rifampicin are the two ear drop antibiotics commonly used for the probabilistic treatmentof otitis in Madagascar. This study aimedto determine the potentially dangerous bacteria involved in otitis and to identify their resistance to fluoroquinolone or rifampicin. Method: A pro-spective study was conducted with the collaboration ofthe Ear Nose and Throat unit (ENT) at the laboratory of UHC PZaGa in Mahajanga. In whole, 56 patients were included. Samplings of otorrhoeawere performed by aspirating the auditory canal using 2ml sterile syringeand then were headed to thelaboratory in less than 30 minutes for analysis. Results:Amidst identified microorganisms were fungus (4,7%) and bacteria (95,3%) to which Gram-negative bacilli represented72.1% (n=44), Gram-positive cocci 6.4% (n=10), Gram-positive bacilli 8.2% (n=5) and Gram-negative cocci 3.3% (n=2). Amongthese bacterias, Pseudomonas aeruginosa and Proteus sp were predominant, with respec-tively 41% (n=25), 23% (n=14). However,three casesof S. aureusreported six with negative coagulaseStaphylococ-cus, one with Escherichia coli, one with Klebsiella sp, one with Haemophilus sp, two cases with Neisseria sp and four cases with Corynebacterium sp. Two types of cultures were noticed, one of them monomorphic (91.1%, n=51) and the other polymorphic (8.9%, n=5) to which three associations of P. aeruginosa-Proteus sp, 1 association of P. aerugino-sa-coagulase-negative Staphylococcus and one association of P. aeruginosa-E. coli. No resistance to ciprofloxacin was observed with Pseudomonas, Neisseria sp, Haemophilus, and enterobacteria except for E. coli. No resistance to rifampicin was observed with S. aureus. However, the sensitivity of S. aureus to ciprofloxacin decreased(one bacte-rium out of three). Conclusion:The use of rifampicin or fluoroquinolones should be based on the type of ear infec-tions. Rifampicin is suggested only if S. aureuswas responsible for otitis. Ciprofloxacin use is still yet sensible to Gram-negative bacilli.
Vacuum And Thermoplastic Mould-based Immobilization Systems Used In Patient Undergoing Pelvic Radiation Therapy: A Comparative Study
(Sumathi Publications, 2020-01) Virkar, Mayuresh; Kumar, N Arul; Chadha, Pranav; Rodrigues, Reuben Jake; Kharde, Anup
Introduction: The aim of the present study was to compare two immobilization systems for comparison of setup errors in targeted radiotherapy. Methods: Retrospective analysis was done for the patients undergoing radiotherapy from May 2012 to December 2018 at our institution. Immobilization was performed on 30 patients sessions (Vacuum cushion i.e., Vac-Lok™ = 15; Thermoplastic mould i.e., Pelvicast pelvic masks = 15). A total of 763 cone-beams were analysed. The target lesion location was verified by cone-beam computed tomography (CBCT) prior to each session, with displacements assessed by CBCT simulation prior to each treatment session. Systematic setup errors, random setup errors, isocenter deviations in the Medio-lateral (ML), Supero-inferior (SI), Antero-posterior (AP), Rotation (yaw) directions of the patient position was calculated. Results: On comparing the Vac-Lok™ and Pelvicast pelvic masks group with respect to Systematic and random error in the lateral, longitudinal, vertical and YAW direction, no statistically significant difference was seen except the random error in YAW direction (P=0.037, Unpaired t-test). There was no difference observed in comparing the isocentric deviation. Conclusion: It was inferred and concluded that using a vacuum cushion for pelvic radiotherapy provides no added benefit compared to using a thermoplastic mould. Thermoplastic mould is recommended for patients receiving pelvic radiotherapy to improve overall reproducibility
Association Between Serum Uric Acid And Hba1c In Patients With Type 2 Diabetes Mellitus: A Case Control Study In Indian Population
(Sumathi Publications, 2020-01) Verma, Indu; Nimesh, Archana
Background and Aim:Uric acid is a pro-oxidant molecule that might be implicated in increasing oxidative stress and insulin resistance in type 2 diabetes mellitus patients. Hence, the aim of the study was to assess serum uric acid and HbA1clevel (an indicator of glycemic control) in these patients and speculate the association between the two. Meth-ods:40 newly diagnosed cases of Type 2 diabetes mellitus (20 males and 20 females) with age ranging between 35-70 years were statistically compared against 40 age and sex-matched healthy subjects with respect to their uric acid and HbA1c levels. Demographic data like the height and weight of patients was also recorded and statistically compared. Results:No statistical difference in age, height and weight were observed in type 2 diabetes cases vs. controls indicat-ing that the groups were comparable. HbA1c and uric acid levels of males and females with type 2 diabetes mellitus were significantly higher in comparison to normal males and females (controls). Correlation analysis showed a posi-tive and significant correlation between HbA1c and uric acid levels in male and female cases of type 2 diabetes melli-tus. Conclusion:Uric acid might have a role in the development or worsening of type 2 diabetes mellitus. However, further studies are required with a larger sample size to clearly establish the relationship between uric acid and glyce-mic control in type 2 diabetes mellitus since studies in the literature have shown conflicting results and hence the un-derstanding of the etiopathogenesis of type 2 diabetes mellitus remains poorly understood with respect to uric acid
Seroprevalence Of Hiv, Hepatitis B And C And Syphilis Among Men Having Sex With Men In Mahajanga (magadascar)
(Sumathi Publications, 2020-01) Riana, Rakotondrazaka H.; Rivo, Rakotomalala; CathÃ©rine, Razafindrakoto A.; Tsiry, Ramavoson; Tahirimalala, Rabenandrianina; Davidra, Rajaonatahiana; Ralison, Fidiarivony; Rakoto, Alson A. Olivat; Razanakolona, L. Rasoamialy; Rasamindrakotroka, Andry; Randriamanantany, Z Arivelo
Sexually transmitted diseases (STD) are public health concerns worldwide. The aim of our study is to assess infection and coinfection with HIV, hepatitis B, hepatitis C and syphilis among men having sex with men in Mahajanga which is a western coastal town of Madagascar. We conducted a prospective and descriptive preliminary study in the laboratory of the University Hospital Center PZAGA in Mahajanga during a period of three months, from December 2014 to February 2015. We included 100 MSM in our study. Their mean age was 36 yrs (16 to 55 yrs). We found 30% of seropositive men among our sample. HIV positive men are mainly part of the age group [20–29 yrs]. The mean age of positive men was respectively 38 yrs., 36 yrs., 48 yrs.and 39 yrs. for HIV, for HBV, HCV, and syphilis. We found respectively for hepatitis B, hepatitis C and syphilis 7%, 1% and 11% positive samples. We found no co-infection HIV and HCV for them. But we found 5% of coinfection HIV-HBV, 4% of coinfection HIV-syphilis and 1% of coinfection of HIV, HBV and syphilis. We highlighted a very high rate of HIV positivity among MSM living in Mahajanga. Efforts have to be made in order to sensitize them about risky behaviors.
Prevalence Of Tobacco Consumption Among Adolescents From Rural Area Of Wardha District
(Sumathi Publications, 2019-01) Kumar, Vishnoi Ravindra; Wagh, Vasant; Gaidhane, Abhay; Pramita, Muntode; Prajapati, Kshatrapal
Background-Globally adolescent population is around 1200 million and out of six person, every one person is in ado-lescence (aged10 to 19 years) period. Yet most of them are healthy, but premature death, illness and injury among them can hinder ability to grow and develop to their full potential. It is estimated that 1.2 million adolescents died in 2015 and mostly from preventable or treatable causes. Tobacco consumption is world’s leading cause of preventable morbidity and mortality. National Family Health Survey conducted in year 2016-17 reported tobacco consumption prevalence 38.9% in urban area and 48% in rural area of India. Method-It was a community based cross-sectional study conducted in eight villages of Wardha district adopted under Community Health Care program run by depart-ment of community medicine. Data was collected by interview from 485 adolescent in the age group of 10-19 years by domiciliary visits using pre-designed pre-tested questionnaire. Results:Prevalence of tobacco use (all forms), smoke-less tobacco use and smoking in rural adolescents were 20.82%, 20.41%, and 2.68%, respectively. Prevalence of to-bacco use in boys (30.29%) was more than girls (4.49%). Higher Prevalence was found in late adolescent period. Bidi was commonly used form of smoke tobacco while Kharra was the preferred smokeless tobacco. Almost all smokers were male but few exceptions were there. Conclusion: The prevalence of tobacco use among rural adolescents was very high (20.82%) as compared to national prevalence of 14.6% according to the global youth tobacco survey India 2009. There is a need of early intervention for tobacco cessation as overall mean age of 1st experienced to tobacco consumption was 12.02 years and in male and female users it was 12.25 years and 10.88 years respectively. 42.10 % adolescents 1st time experienced any type of tobacco products when they were in the 12-14 years age and only 0.66% adolescents experienced at the age of 17 -19 years. Maximum male (42.19%) and female (41.67%) ever user experi-enced their 1st tobacco consumption when they were 12-14 years old.
Perceptions Of Women About Breast Cancer In Rural Area Of Wardha District
(Sumathi Publications, 2019-01) N, Gondnale Goral; Ingole, Abhishek; Mudey, Abhay; Kshatrapal, Prajapati
Background:The incidence of breast cancer is seen to be low in India as compared to western countries, however the mortality is low. The knowledge about breast cancer, breast awareness and self-breast examination is the need of the hour. Breast Cancer, if caught in the early stages, makes it curable by various modalities of treatment. Our study aims here to qualitatively explore the views and ideas of the women in rural area about breast cancer and the need of a bet-ter comprehensive program. Method: A community based cross-sectional study was carried out with a sample size of 672 with a pre-tested questionnaire with open-ended questions for qualitative exploration. It was done by door-to-door survey. Resident females of the village above 30years were included and females with chronic illness and temporary residents were excluded. Results:The mean age of participants was 42.38±9.76 years with 48.2% educated till sec-ondary school and 83.2% belonged to OBC category. The perceptions were assessed with qualitative findings where it was found that most of the females believed that they don’t have breast cancer even before getting screened and so they didn’t want to get mammography. However they affirmed that a doorstep approach of activities would be benefi-cial. They also said that doorstep activities help get good information of breast cancer signs and symptoms and pro-gram like this will be a good approach. Conclusion: Doorstep approach can be a welcome change in imparting aware-ness
Efficacy, Tolerability And Safety Of Intravenous Iron Sucrose In Postpartum Anaemia
(Sumathi Publications, 2019-01) Rajput, Rucha; Podey, Ashish; Baheti, Tushar; Bangal, V B; Deshpande, Sarita
Background:Anemia is one of major contributing factor in maternal mortality and morbidity in third world countries and according to the WHO, contributes to 40% maternal deaths. Postpartum anemia is observed in up to 27% of wom-en.It is a common problem throughout the world. Treatment of postpartum iron deficiency anemia includes oral and parenteral iron supplmentaion as well as blood transfusion in severe cases. Methods: This was a prospective longitudi-nal study carried out in Department of Obstetrics & Gynaecology of PRH, Loni. Total 80 women suffering from post-partum anemia of age above 18 years with haemoglobin (HB) level below 11gm/dl and above 6gm/dl were included for the study. After history taking, clinical examination and baseline Hb level, all of them were administered intrave-nous iron sucrose 200 mg per dose per day till the total calculated dose was administered. The post therapy evaluation was done with the estimation of Hb on day 1, day 7, day 14 and day 21. Results:31.25% women belonged to the age group each of 19-21 years and 22-24 years. Maximum number of patients received 3 doses of IV Iron sucrose (i.e. total 600mg) followed by 2 doses (i.e. total 400mg), 4 doses (i.e. total 800mg) and 5 doses (i.e. total 1000mg) respec-tively. Hb level rises extremely significantly (p<0.001) after IV Iron Sucrose administration on day 1, 7, 14 & 21 as compared to corresponding values before delivery as analyzed by Friedman Test (Nonparametric Repeated Measures ANOVA) . 16 patients (20%) experienced thrombophlebitis to IV Iron Sucrose administration. About 12 (15%) pa-tients experienced rigor followed by sweating in 10 patients (12.5%) and fever in 8 patients (10%). About 62 patients (77.5%) from total 80 reported well tolerability to IV Iron Sucrose while remaining 18 patients (22.5%) reported poor tolerability to IV Iron Sucrose Conclusion:Intravenous iron sucrose increases the haemoglobin more rapidly in first week as compared to second and third week in women with postpartum iron deficiency anemia. Hypersensitivity reac-tion, chest pain, dyspnoea reported with iron dextran and iron sorbitol citric acid were not observed with iron sucrose. Intravenous iron sucrose can be used safely to fill a rift between blood transfusion and oral iron in treatment of post-partum iron deficiency anemia.
In Silico Design Of Potential 1,5-benzothiazepine Derivatives As An Anti- Convulsant Agent By Molecular Docking Studies
(Sumathi Publications, 2019-07) Parjane, Smita; Kunkulol, Rahul; Dattatray, Nandal
Epilepsy is characterized by the presence of recurrent seizures. A seizure can be defined as “an episodic disturbance of movement, feeling, or consciousness caused by sudden synchronous, inappropriate, and excessive electrical discharges in the cerebral cortex”. One in every three patients with epilepsy is probable to be severely disabled. It is continuing this scenario as an attempt to develop potent and nontoxic anti-convulsant agents. Recently discovery of benzothiazepine derivatives as an anticonvulsant agent is significant area for research in medicinal chemistry as it is free from all side effects which is shown by a developed as an anticonvulsant agent. In this paper, we have presented results of 2D, and 3D docking poses studies of a series of 300 (Three series) molecules containing 1,5-benzothiazepine pharmacophore as anti-convulsant agents. Docking analysis was utilized to predict the mechanism of action of the designed derivatives for anticonvulsant potential. All the molecules exhibited binding score in the range of -82.61 to -118.25 kcal/mol. Most active molecules from Series 1, 2 and 3 exhibited hydrogen bond interactions with LEU282B, LEU282B and LEU282B. Also for the selected standard sodium phenytoin showed the hydrogen bond interaction with LYS637A. It was noted that the docking score of 1a to 10a, 101b to 110b and 201c to 210c was almost same as that of selected standard sodium phenytoin. Protein showed hydrogen bonding with all synthesized compound showed potential against the epilepsy with GABA nergic mechanism.
Awareness And Effect Of Janani Suraksha Yojana On Antenatal Care And Institutional Deliveries In Rural, Urban & Tribal Areas Of Ahmednagar District.
(Sumathi Publications, 2019-01) Dhakne, Swathi; Phalke, Deepak
Janani Suraksha Yojana (JSY) is a centrally sponsored scheme which is being implemented with the objective of re-ducing maternal and infant mortality by promoting institutional delivery among pregnant women. The Government of India introduced the JSY (safe motherhood program) based on the principles of CCT. Under JSY, cash assistance was given to pregnant women receiving at least three antenatal check-ups (ANCs) and delivering at institutions. The study is undertaken to establish if there is any co-relation of level of awareness about the scheme and its impact on ANC and institutional deliveries in the rural, urban and tribal area of Ahmednagar district. Method: The JSY beneficiaries were asked demographic characteristics, area of residency, educational levels, Category and place of delivery were noted. A set of question (self-designed and pretested) and their responses were noted. Result: Out of 825 JSY beneficiaries, there were total 781 (94.7%) Hindu, Muslim 23(2.8%) and Christian 21 (2.5%) beneficiaries. Majority of Hindu reli-gion JSY beneficiaries. Only few member from BPL JSY beneficiaries have opted for delivery at private hospital. Maximum deliveries taking place in civil hospital are from BPL category. It was observed that the awareness level about JSY is low in tribal area compared to the rural and urban area. It was also seen that 648 (78.54%) JSY benefi-ciaries availed free transport facility out of which 358 (55.24%) fall in high level of awareness category. There is a positive relation between age group and awareness about JSY. Conclusion: 46.8% women with high awareness about JSY scheme, it is a programme for pregnant women which aims at safe institutional delivery. Other factors such as education of mother, religion, culture, area of residence, family type played important role in utilization of available maternal health scheme.
Parental Perception Of Low Iq Facts Or Fiction: Retrospective Data From Clinic In Semi Rural Maharashtra
(Sumathi Publications, 2019-10) Tamboli, Suchit Suresh; Joglekar, Charudatt; Desle, Vasant; Tamboli, Anvesh
Objective: To study the association between physical and psychological problems perceived by parents and the IQ of their children. Methods: We studied 981 children in the child development center at Ahmednagar. Median age at followup was 7.8y (Q25=5.6y and Q75=10.4y, Babies underwent IQ evaluation by Binet Kamat scale (n=981); also their physical and psychological problems perceived by parents were documented. We categorized children into 4 categories using number of problems (physical and psychological separately) viz 1 (no problem), 2 (1 problem), 3 (2 problems), 4 (>2 problems). When we looked at physical problem data, 555 (56.6%) had no problem, 251 (25.6%) had 1, 117 (11.9%) had 2, and remaining 58 (5.9%) had more than 2. For psychological problems like not interested in studies, speech problems don't remember, don't understand, cannot concentrate, fears, etc. The distribution was 221 (22.5%), 212 (21.6%), 222 (22.6%) and 326 (33.3%) respectively. Result: The increasing trend of mean IQ for physical problem parameters from nil to >2 categories and decreasing prevalence of low IQ using Binet Kamat scale were not significant. However, for psychological problems the decreasing and statistically significant trend (p=0.000) was present for mean IQ, and a significant increasing trend (p=0.029) for prevalence of low IQ was observed. Conclusion: Psychological problems were associated with IQ. Numbers of problems were inversely correlated with IQ.

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