In Silico Design Of Potential 1,5-benzothiazepine Derivatives As An Anti- Convulsant Agent By Molecular Docking Studies
Loading...
Date
2019-07
Journal Title
Journal ISSN
Volume Title
Publisher
Sumathi Publications
Abstract
Epilepsy is characterized by the presence of recurrent seizures. A seizure can be defined as “an episodic disturbance of movement, feeling, or consciousness caused by sudden synchronous, inappropriate, and excessive electrical discharges in the cerebral cortex”. One in every three patients with epilepsy is probable to be severely disabled. It is continuing this scenario as an attempt to develop potent and nontoxic anti-convulsant agents. Recently discovery of benzothiazepine derivatives as an anticonvulsant agent is significant area for research in medicinal chemistry as it is free from all side effects which is shown by a developed as an anticonvulsant agent. In this paper, we have presented results of 2D, and 3D docking poses studies of a series of 300 (Three series) molecules containing 1,5-benzothiazepine pharmacophore as anti-convulsant agents. Docking analysis was utilized to predict the mechanism of action of the designed derivatives for anticonvulsant potential. All the molecules exhibited binding score in the range of -82.61 to -118.25 kcal/mol. Most active molecules from Series 1, 2 and 3 exhibited hydrogen bond interactions with LEU282B, LEU282B and LEU282B. Also for the selected standard sodium phenytoin showed the hydrogen bond interaction with LYS637A. It was noted that the docking score of 1a to 10a, 101b to 110b and 201c to 210c was almost same as that of selected standard sodium phenytoin. Protein showed hydrogen bonding with all synthesized compound showed potential against the epilepsy with GABA nergic mechanism.
Description
Keywords
Anti - convulsant, 1,5 - benzothiazepine, V - Life MDS 4.3
Citation
Parjane Smita, Kunkulol Rahul, Dattatray Nandal. In Silico Design Of Potential 1,5-benzothiazepine Derivatives As An Anti- Convulsant Agent By Molecular Docking Studies. International Journal of Clinical and Biomedical Research. 2019 Jul; 5(3): 29-36