Background: Microalbuminuria in type 2 diabetic patients is speculated to be accompanied by elevated serum high sensitivity C reactive protein (hsCRP). . Establishing a correlation between hsCRP & microalbuminuria relative to duration of diabetes suggests activation of inflammatory pathways in progression of kidney disease .
Materials &Methods: 120 diabetic individuals aged (30-60) yrs ,divided in 3 groups of 40 subjects in each, namely: a) newly diagnosed˂5 years b) 5-10 years after diagnosis and c) ≥10 years after diagnosis were recruited from a tertiary care hospital in sub Himalayan region according to some inclusion and exclusion criteria.
Result: Mean values of hsCRP were 0.04 ± 0.005, 0.08 ± 0.011, & 0.10 ± 0.017 and that of micro albumin were 95.42 ± 12.30, 116.79 ± 4.87 & 130.56 ± 7.65 in group 1,2 ,3 respectively. One way ANOVA with post hoc analysis after Bonferroni correction depicted that both hsCRP & micro albumin increased significantly and statistically with duration of diabetes in all 3 groups along with a very significant correlation between them .
Conclusion:Both serum hsCRP and microalbuminuria increases with period of diabetes.So the increasing trend of these inflammatory markers needs to be noted early and monitored to prevent progression of diabetic nephropathy