Isonicotinic acid hydrazide inhibits cell population growth during teratogenesis of chick embryo.
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1991-01-01
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Abstract
In chick embryos treated with a 4 hr pulse of 7.2 X 10(-5) M isonicotinic acid hydrazide (INH) the cell population growth is inhibited with an increased population doubling time. Teratogenised blastoderm cells complete their ongoing cell cycle and arrest in G1 phase. A chase with an equimolar concentration of pyridoxal-5-phosphate restores the growth rate after a lag of 4 hr equivalent to the duration of treatment with INH. Presumptive mesoblast cells invaginated through the primitive streak and neuroectoblast cells induced prior to the application of INH differentiate, while the teratogen inhibits morphogenesis and organization of organ primordia.
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Joshi MV, Shah VB, Modak SP. Isonicotinic acid hydrazide inhibits cell population growth during teratogenesis of chick embryo. Indian Journal of Experimental Biology. 1991 Jan; 29(1): 12-5