Isonicotinic acid hydrazide inhibits cell population growth during teratogenesis of chick embryo.

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dc.contributor.authorJoshi, M Ven_US
dc.contributor.authorShah, V Ben_US
dc.contributor.authorModak, S Pen_US
dc.date.accessioned2009-05-28T12:52:09Z
dc.date.available2009-05-28T12:52:09Z
dc.date.issued1991-01-01en_US
dc.description.abstractIn chick embryos treated with a 4 hr pulse of 7.2 X 10(-5) M isonicotinic acid hydrazide (INH) the cell population growth is inhibited with an increased population doubling time. Teratogenised blastoderm cells complete their ongoing cell cycle and arrest in G1 phase. A chase with an equimolar concentration of pyridoxal-5-phosphate restores the growth rate after a lag of 4 hr equivalent to the duration of treatment with INH. Presumptive mesoblast cells invaginated through the primitive streak and neuroectoblast cells induced prior to the application of INH differentiate, while the teratogen inhibits morphogenesis and organization of organ primordia.en_US
dc.description.affiliationDepartment of Zoology, University of Poona, India.en_US
dc.identifier.citationJoshi MV, Shah VB, Modak SP. Isonicotinic acid hydrazide inhibits cell population growth during teratogenesis of chick embryo. Indian Journal of Experimental Biology. 1991 Jan; 29(1): 12-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58658
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Differentiation --drug effectsen_US
dc.subject.meshCell Division --drug effectsen_US
dc.subject.meshChick Embryoen_US
dc.subject.meshIsoniazid --antagonists & inhibitorsen_US
dc.subject.meshPyridoxal Phosphate --pharmacologyen_US
dc.subject.meshTeratogens --toxicityen_US
dc.titleIsonicotinic acid hydrazide inhibits cell population growth during teratogenesis of chick embryo.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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