A Clinical and Preliminary Study for Anti-angiogenesis Therapy: Endostatin, VEGF and Microvessel Density in the OSCC in Different Stages and Differentiations
Loading...
Date
2020-02
Journal Title
Journal ISSN
Volume Title
Publisher
SCIENCEDOMAIN international
Abstract
Aims: This study was to analyze the association among ES, VEGF,Microvessel Density (MVD),clinicopathologic characteristics, angiogenesis and prognosis of OSCC. Methods: Eight normal samples of oral epithelia and 52 Oral Squamous Cell Carcinoma (OSCC) samples were analyzed by immunohistochemical evaluation to study the expression and significance of Endostatin (ES) and Vascular Endothelial Growth Factor (VEGF) during the development of OSCC. Results: Statisticallysignificant differences were found as p<0.05 between VEGF expressions and clinicopathologic stages of OSCC and as p<0.01 between VEGF expressions and lymph node metastases of OSCC. And Statisticallysignificant discrepancy was also found as p<0.05 between MVD and differentiation degrees and lymphnode metastases of OSCC, as well asp<0.01 between VEGF expressions andMVD. Additionally MVD increased gradually in accordance with the progression of the Cancer. While there was no obvious correlation between ES and VEGF, ES and MVD, as well as between ES and the development of OSCC. Conclusion:By MVD etal evaluation,VEGF is one of the major angiogenesis factors for angiogenesis and lymphonodemetastasis of oral carcinomas, as an important indicator for the development and malignancy of OSCC,while ES is of significance for anti-angiogenesis in tumor therapy
Description
Keywords
Endostatin, vascular endothelial growth factor, microvessel density, OSCC, immunohistochemistry
Citation
He Hong, Wang Jiaqin, Deng Xiaotong, Zhao Danping. A Clinical and Preliminary Study for Anti-angiogenesis Therapy: Endostatin, VEGF and Microvessel Density in the OSCC in Different Stages and Differentiations. Journal of Advances in Medicine and Medical Research. 2020 Feb; 32(1): 71-79