A Clinical and Preliminary Study for Anti-angiogenesis Therapy: Endostatin, VEGF and Microvessel Density in the OSCC in Different Stages and Differentiations

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dc.contributor.authorHe, Hongen_US
dc.contributor.authorWang, Jiaqinen_US
dc.contributor.authorDeng, Xiaotongen_US
dc.contributor.authorZhao, Danpingen_US
dc.date.accessioned2020-10-16T08:53:35Z
dc.date.available2020-10-16T08:53:35Z
dc.date.issued2020-02
dc.description.abstractAims: This study was to analyze the association among ES, VEGF,Microvessel Density (MVD),clinicopathologic characteristics, angiogenesis and prognosis of OSCC. Methods: Eight normal samples of oral epithelia and 52 Oral Squamous Cell Carcinoma (OSCC) samples were analyzed by immunohistochemical evaluation to study the expression and significance of Endostatin (ES) and Vascular Endothelial Growth Factor (VEGF) during the development of OSCC. Results: Statisticallysignificant differences were found as p<0.05 between VEGF expressions and clinicopathologic stages of OSCC and as p<0.01 between VEGF expressions and lymph node metastases of OSCC. And Statisticallysignificant discrepancy was also found as p<0.05 between MVD and differentiation degrees and lymphnode metastases of OSCC, as well asp<0.01 between VEGF expressions andMVD. Additionally MVD increased gradually in accordance with the progression of the Cancer. While there was no obvious correlation between ES and VEGF, ES and MVD, as well as between ES and the development of OSCC. Conclusion:By MVD etal evaluation,VEGF is one of the major angiogenesis factors for angiogenesis and lymphonodemetastasis of oral carcinomas, as an important indicator for the development and malignancy of OSCC,while ES is of significance for anti-angiogenesis in tumor therapyen_US
dc.identifier.affiliationsThe Affiliated Stomatology Hospital, Zhejiang University School of Medicine, Chinaen_US
dc.identifier.affiliationsKey Laboratory of Oral Biomedical Researchof Zhejiang Province, Zhejiang University School of Stomatology,Chinaen_US
dc.identifier.affiliationsThe Affiliated Stomatology Hospital, Zhejiang University School of Medicine, Chinaen_US
dc.identifier.affiliationsKey Laboratory of Oral Biomedical Researchof Zhejiang Province, Zhejiang University School of Stomatology,Chinaen_US
dc.identifier.affiliationsThe Affiliated Stomatology Hospital, Zhejiang University School of Medicine, Chinaen_US
dc.identifier.affiliationsKey Laboratory of Oral Biomedical Researchof Zhejiang Province, Zhejiang University School of Stomatology,Chinaen_US
dc.identifier.affiliationsSecond Affiliated Hospital, Zhejiang University School of Medicine, Chinaen_US
dc.identifier.citationHe Hong, Wang Jiaqin, Deng Xiaotong, Zhao Danping. A Clinical and Preliminary Study for Anti-angiogenesis Therapy: Endostatin, VEGF and Microvessel Density in the OSCC in Different Stages and Differentiations. Journal of Advances in Medicine and Medical Research. 2020 Feb; 32(1): 71-79en_US
dc.identifier.issn2456-8899
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210373
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber1en_US
dc.relation.volume32en_US
dc.source.urihttps://dx.doi.org//10.9734/JAMMR/2020/v32i130351en_US
dc.subjectEndostatinen_US
dc.subjectvascular endothelial growth factoren_US
dc.subjectmicrovessel densityen_US
dc.subjectOSCCen_US
dc.subjectimmunohistochemistryen_US
dc.titleA Clinical and Preliminary Study for Anti-angiogenesis Therapy: Endostatin, VEGF and Microvessel Density in the OSCC in Different Stages and Differentiationsen_US
dc.typeJournal Articleen_US
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