A Comparative Study to Assess the Efficacy and Safety of Combination Capsules of Paroxetine and Clonazepam in comparison to Paroxetine in patients suffering from Co-morbid Depression and Anxiety.
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Date
2011-04
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Abstract
Depression and anxiety disorders are distinct illnesses that often coexist. Patients suffering
from both disorders have more psychological, physical, and social impairment than do
patients suffering from either illness alone. An open label comparative multicentric study
was conducted to assess the efficacy and safety of therapy with fixed dose combination
capsules of Paroxetine (25 mg) controlled release (CR) and Clonazepam (0.5 mg) in
comparison to Paroxetine (25 mg) controlled release (CR) tablets in Indian patients suffering
from co-morbid depression and anxiety. Patients between 18-65 years of age and established
diagnosis of co-morbid depression and anxiety (as per Diagnostic and Statistical Manual
of Mental Disorders, Fourth Edition [DSM-IV]) with a total Hamilton Rating Scale for
Depression (HAM-D) score 14 and total Hamilton Rating Scale for Anxiety (HAM-A)
score 12 were screened for enrolment in the study after taking their informed consent. The
primary efficacy variables were the change in the score on the Hamilton Rating Scale for
Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) at the end of
treatment as compared to baseline. There was a significant decline in the mean HAM-D
score from 21.4 ± 2.5 (range: 17-27) at baseline to 11.7 ± 1.8 (range: 8-15) at the end of
the treatment in Group A and from 20.4 ± 2.1 (range: 16-23) at baseline to 12.0 ± 1.1
(range: 10-14) at the end of the treatment in Group B. In conclusion, we found that the
fixed dose combination capsules of Paroxetine (25 mg) controlled release (CR) and
Clonazepam (0.5 mg) are more effective and equally well tolerated as Paroxetine (25 mg)
controlled release (CR) tablets in the management of patients with co-morbid depression
and anxiety at our centre.
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Keywords
Comorbid Depression, Anxiety, Paroxetine, Clonazepam
Citation
Jagawat Tushar, A Comparative Study to Assess the Efficacy and Safety of Combination Capsules of Paroxetine and Clonazepam in comprasion to Paroxetine in patients suffering from Co-morbid Depression and Anxiety. Delhi Psychiatry journal. 2011 Apr; 14 (1): 106-109.