A Comparative Study to Assess the Efficacy and Safety of Combination Capsules of Paroxetine and Clonazepam in comparison to Paroxetine in patients suffering from Co-morbid Depression and Anxiety.

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dc.contributor.authorJagawat, Tushar
dc.date.accessioned2015-07-09T06:15:24Z
dc.date.available2015-07-09T06:15:24Z
dc.date.issued2011-04
dc.description.abstractDepression and anxiety disorders are distinct illnesses that often coexist. Patients suffering from both disorders have more psychological, physical, and social impairment than do patients suffering from either illness alone. An open label comparative multicentric study was conducted to assess the efficacy and safety of therapy with fixed dose combination capsules of Paroxetine (25 mg) controlled release (CR) and Clonazepam (0.5 mg) in comparison to Paroxetine (25 mg) controlled release (CR) tablets in Indian patients suffering from co-morbid depression and anxiety. Patients between 18-65 years of age and established diagnosis of co-morbid depression and anxiety (as per Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition [DSM-IV]) with a total Hamilton Rating Scale for Depression (HAM-D) score 14 and total Hamilton Rating Scale for Anxiety (HAM-A) score 12 were screened for enrolment in the study after taking their informed consent. The primary efficacy variables were the change in the score on the Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) at the end of treatment as compared to baseline. There was a significant decline in the mean HAM-D score from 21.4 ± 2.5 (range: 17-27) at baseline to 11.7 ± 1.8 (range: 8-15) at the end of the treatment in Group A and from 20.4 ± 2.1 (range: 16-23) at baseline to 12.0 ± 1.1 (range: 10-14) at the end of the treatment in Group B. In conclusion, we found that the fixed dose combination capsules of Paroxetine (25 mg) controlled release (CR) and Clonazepam (0.5 mg) are more effective and equally well tolerated as Paroxetine (25 mg) controlled release (CR) tablets in the management of patients with co-morbid depression and anxiety at our centre.en_US
dc.identifier.citationJagawat Tushar, A Comparative Study to Assess the Efficacy and Safety of Combination Capsules of Paroxetine and Clonazepam in comprasion to Paroxetine in patients suffering from Co-morbid Depression and Anxiety. Delhi Psychiatry journal. 2011 Apr; 14 (1): 106-109.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/159368
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/daa/t11/i1/daat11i1p106.pdfen_US
dc.subjectComorbid Depressionen_US
dc.subjectAnxietyen_US
dc.subjectParoxetineen_US
dc.subjectClonazepamen_US
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAnxiety --drug therapy
dc.subject.meshClonazepam --administration & dosage
dc.subject.meshDepression --drug therapy
dc.subject.meshDrug Combinations
dc.subject.meshDrug Evaluation
dc.subject.meshHumans
dc.subject.meshMiddle Aged
dc.subject.meshParoxetine --administration & dosage
dc.subject.meshPharmacokinetics
dc.subject.meshPredictive Value of Tests
dc.subject.meshPsychiatric Status Rating Scales
dc.subject.meshTherapeutic Equivalency
dc.subject.meshYoung Adult
dc.titleA Comparative Study to Assess the Efficacy and Safety of Combination Capsules of Paroxetine and Clonazepam in comparison to Paroxetine in patients suffering from Co-morbid Depression and Anxiety.en_US
dc.typeArticleen_US
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