Estimation of N‑terminal telopeptides of type I collagen in periodontal health, disease and after nonsurgical periodontaltherapy in gingival crevicular fluid: A clinico ‑ biochemical study.
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Date
2015-03
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Abstract
Aim: This study explored gingival crevicular fluid (GCF) N‑terminal telopeptides of type I
collagen (NTx) levels in periodontal health, disease and after nonsurgical periodontal therapy
along with its association with the clinical parameters.
Materials and Methods: Study comprised of three groups of 10 subjects each: Healthy (Group I),
gingivitis (Group II), and periodontitis (Group III), while Group III patients after scaling and
root planning (SRP) constituted Group IV. Gingival index (GI), probing pocket depth (PPD),
clinical attachment loss (CAL), and radiological parameters were recorded. GCF samples were
analyzed by competitive‑enzyme‑linked immunosorbent assay.
Results: Samples in Group III and Group IV tested positive for NTx whereas in Group I and
Group II, NTx was not detected. Mean NTx levels were higher in Group III (6.79 ± 0.94 nanomole
bone collagen equivalents per liter [nm BCE/L]) compared to Group IV (5.73 ± 0.95 nm BCE/L)
which was statistically significant. Positive correlation was seen between the clinical parameters
and the NTx levels in Group III and IV.
Conclusion: As NTx is specific bone turnover marker, it is detected only in periodontitis Group
and the values decline after SRP. Failure to detect NTx in Group I and II, relates to the minimum
or no resorption at the sample sites.
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Keywords
Collagen, gingival crevicular fluid, N‑telopeptide, periodontitis
Citation
Aruna G. Estimation of N‑terminal telopeptides of type I collagen in periodontal health, disease and after nonsurgical periodontaltherapy in gingival crevicular fluid: A clinico ‑ biochemical study. Indian Journal of Dental Research. 2015 Mar-Apr; 26(2): 152-157.