Estimation of N‑terminal telopeptides of type I collagen in periodontal health, disease and after nonsurgical periodontaltherapy in gingival crevicular fluid: A clinico ‑ biochemical study.

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dc.contributor.authorAruna, G
dc.date.accessioned2015-06-24T07:38:45Z
dc.date.available2015-06-24T07:38:45Z
dc.date.issued2015-03
dc.description.abstractAim: This study explored gingival crevicular fluid (GCF) N‑terminal telopeptides of type I collagen (NTx) levels in periodontal health, disease and after nonsurgical periodontal therapy along with its association with the clinical parameters. Materials and Methods: Study comprised of three groups of 10 subjects each: Healthy (Group I), gingivitis (Group II), and periodontitis (Group III), while Group III patients after scaling and root planning (SRP) constituted Group IV. Gingival index (GI), probing pocket depth (PPD), clinical attachment loss (CAL), and radiological parameters were recorded. GCF samples were analyzed by competitive‑enzyme‑linked immunosorbent assay. Results: Samples in Group III and Group IV tested positive for NTx whereas in Group I and Group II, NTx was not detected. Mean NTx levels were higher in Group III (6.79 ± 0.94 nanomole bone collagen equivalents per liter [nm BCE/L]) compared to Group IV (5.73 ± 0.95 nm BCE/L) which was statistically significant. Positive correlation was seen between the clinical parameters and the NTx levels in Group III and IV. Conclusion: As NTx is specific bone turnover marker, it is detected only in periodontitis Group and the values decline after SRP. Failure to detect NTx in Group I and II, relates to the minimum or no resorption at the sample sites.en_US
dc.identifier.citationAruna G. Estimation of N‑terminal telopeptides of type I collagen in periodontal health, disease and after nonsurgical periodontaltherapy in gingival crevicular fluid: A clinico ‑ biochemical study. Indian Journal of Dental Research. 2015 Mar-Apr; 26(2): 152-157.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/158282
dc.language.isoenen_US
dc.source.urihttps://www.ijdr.in/article.asp?issn=0970-9290;year=2015;volume=26;issue=2;spage=152;epage=157;aulast=Arunaen_US
dc.subjectCollagenen_US
dc.subjectgingival crevicular fluiden_US
dc.subjectN‑telopeptideen_US
dc.subjectperiodontitisen_US
dc.subject.meshCollagen Type I
dc.subject.meshCase-Control Studies
dc.subject.meshControl Groups
dc.subject.meshGingival Crevicular Fluid --analysis
dc.subject.meshHumans
dc.subject.meshPeptides --analogs & derivatives
dc.subject.meshPeptides --analysis
dc.subject.meshPeriodontal Diseases --drug therapy
dc.subject.meshPeriodontal Diseases --therapy
dc.titleEstimation of N‑terminal telopeptides of type I collagen in periodontal health, disease and after nonsurgical periodontaltherapy in gingival crevicular fluid: A clinico ‑ biochemical study.en_US
dc.typeArticleen_US
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