Solubility enhancement of ibuprofen in the presence of hydrophilic polymer and surfactant.
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Date
2010-11
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Abstract
Solid dispersions of ibuprofen (IBU) were prepared by solvent evaporation
method using polyvinyl pyrrolidone (PVP) and/or sodium lauryl sulphate (SLS).
Physicochemical properties of the various solid dispersion systems were determined by
differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analysis. The
results from dissolution studies indicated that ternary solid dispersion systems were more
efficacious than the corresponding binary ones. The increase in the dissolution rate of
ibuprofen from its solid dispersions with the PVP and/or SLS used in this study could be
attributed to several factors such as improved wettability, local solubilisation, and drug
particle size reduction. The most effective solid dispersion was the 20:180:10 w/w IBUPVP-
SLS ternary system, which allowed dissolution of 85 % drug after only 9.15
minutes (in comparison with 94.61 minutes for drug alone and 17.92 minutes for the
binary system).
Description
Keywords
Ibuprofen, solid dispersion, phase solubility study, polyvinyl pyrrolidone, sodium lauryl sulphate, dissolution efficiency
Citation
Giri Tapan Kumar, Badwaik Hemant, Alexander Amit, Tripathi Dulal Krishna. Solubility enhancement of ibuprofen in the presence of hydrophilic polymer and surfactant. International Journal of Applied Biology and Pharmaceutical Technology. 2010 Nov-Dec; 1(3): 793-800.