Solubility enhancement of ibuprofen in the presence of hydrophilic polymer and surfactant.

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dc.contributor.authorGiri, Tapan Kumar
dc.contributor.authorBadwaik, Hemant
dc.contributor.authorAlexander, Amit
dc.contributor.authorTripathi, Dulal Krishna
dc.date.accessioned2015-06-22T11:25:44Z
dc.date.available2015-06-22T11:25:44Z
dc.date.issued2010-11
dc.description.abstractSolid dispersions of ibuprofen (IBU) were prepared by solvent evaporation method using polyvinyl pyrrolidone (PVP) and/or sodium lauryl sulphate (SLS). Physicochemical properties of the various solid dispersion systems were determined by differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analysis. The results from dissolution studies indicated that ternary solid dispersion systems were more efficacious than the corresponding binary ones. The increase in the dissolution rate of ibuprofen from its solid dispersions with the PVP and/or SLS used in this study could be attributed to several factors such as improved wettability, local solubilisation, and drug particle size reduction. The most effective solid dispersion was the 20:180:10 w/w IBUPVP- SLS ternary system, which allowed dissolution of 85 % drug after only 9.15 minutes (in comparison with 94.61 minutes for drug alone and 17.92 minutes for the binary system).en_US
dc.identifier.citationGiri Tapan Kumar, Badwaik Hemant, Alexander Amit, Tripathi Dulal Krishna. Solubility enhancement of ibuprofen in the presence of hydrophilic polymer and surfactant. International Journal of Applied Biology and Pharmaceutical Technology. 2010 Nov-Dec; 1(3): 793-800.en_US
dc.identifier.issn0976-4550
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/158175
dc.language.isoenen_US
dc.source.urihttps://www.ijabpt.com/pdf/3007-Tapan%20Giri[1].pdfen_US
dc.subjectIbuprofenen_US
dc.subjectsolid dispersionen_US
dc.subjectphase solubility studyen_US
dc.subjectpolyvinyl pyrrolidoneen_US
dc.subjectsodium lauryl sulphateen_US
dc.subjectdissolution efficiencyen_US
dc.titleSolubility enhancement of ibuprofen in the presence of hydrophilic polymer and surfactant.en_US
dc.typeArticleen_US
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