Fabrication and in- vitro permeation studies of indomethacin-ficus carica fruit mucilage patches.
Loading...
Date
2010-11
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The main objective of the present study was to develop matrix-moderated
transdermal systems of Indomethacin using various proportions of Ficus carica fruit
mucilage. Physical evaluation was performed such as moisture content, moisture uptake,
tensile strength, flatness and folding endurance. In-vitro permeation studies were performed
in a Keshary-Chien diffusion cell. The matrix-type transdermal systems were prepared using
Indomethacin with Ficus carica fruit mucilage by the solvent evaporation technique. The
interactions between Indomethacin and Ficus carica fruit mucilage were performed. The
transdermal patches were subjected to various physicochemical parameters viz., mechanical
properties, permeation studies and skin irritation studies. The prepared patches possessed
satisfactory pre-formulary and formulary characteristics. In vitro permeation studies were
performed using a Keshary-Chien diffusion cell across hairless Albino rat skin. The non-ionic
surfactants Span 80, Glycerin, Propylene glycol in the formulation played a role as
permeability enhancer. The patches were seemingly free of potentially hazardous skin
irritation. The experimental results shows that the release of drug from the patch delayed in
controlled manner as the proportion of Ficus carica increased. It was concluded that
Indomethacin can be developed as a transdermal patches with Ficus carica fruit mucilage.
Description
Keywords
Indomethacin, Ficus carica fruit mucilage, transdermal patches, in-vitro permeation, skin irritation
Citation
Ahad Hindustan Abdul, Sreeramulu J, Kumar Chitta Suresh, Anuradha C M, Reddy Kishore Kumar, Sushma K, Krishna Z Hari, Savithri R. Fabrication and in- vitro permeation studies of indomethacin-ficus carica fruit mucilage patches. International Journal of Applied Biology and Pharmaceutical Technology. 2010 Nov-Dec; 1(3): 786-792.