Fabrication and in- vitro permeation studies of indomethacin-ficus carica fruit mucilage patches.

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dc.contributor.authorAhad, Hindustan Abdul
dc.contributor.authorSreeramulu, J
dc.contributor.authorKumar, Chitta Suresh
dc.contributor.authorAnuradha, C M
dc.contributor.authorReddy, Kishore Kumar
dc.contributor.authorSushma, K
dc.contributor.authorKrishna, Z Hari
dc.contributor.authorSavithri, R
dc.date.accessioned2015-06-22T11:12:00Z
dc.date.available2015-06-22T11:12:00Z
dc.date.issued2010-11
dc.description.abstractThe main objective of the present study was to develop matrix-moderated transdermal systems of Indomethacin using various proportions of Ficus carica fruit mucilage. Physical evaluation was performed such as moisture content, moisture uptake, tensile strength, flatness and folding endurance. In-vitro permeation studies were performed in a Keshary-Chien diffusion cell. The matrix-type transdermal systems were prepared using Indomethacin with Ficus carica fruit mucilage by the solvent evaporation technique. The interactions between Indomethacin and Ficus carica fruit mucilage were performed. The transdermal patches were subjected to various physicochemical parameters viz., mechanical properties, permeation studies and skin irritation studies. The prepared patches possessed satisfactory pre-formulary and formulary characteristics. In vitro permeation studies were performed using a Keshary-Chien diffusion cell across hairless Albino rat skin. The non-ionic surfactants Span 80, Glycerin, Propylene glycol in the formulation played a role as permeability enhancer. The patches were seemingly free of potentially hazardous skin irritation. The experimental results shows that the release of drug from the patch delayed in controlled manner as the proportion of Ficus carica increased. It was concluded that Indomethacin can be developed as a transdermal patches with Ficus carica fruit mucilage.en_US
dc.identifier.citationAhad Hindustan Abdul, Sreeramulu J, Kumar Chitta Suresh, Anuradha C M, Reddy Kishore Kumar, Sushma K, Krishna Z Hari, Savithri R. Fabrication and in- vitro permeation studies of indomethacin-ficus carica fruit mucilage patches. International Journal of Applied Biology and Pharmaceutical Technology. 2010 Nov-Dec; 1(3): 786-792.en_US
dc.identifier.issn0976-4550
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/158172
dc.language.isoenen_US
dc.source.urihttps://www.ijabpt.com/pdf/95006-indomethacin%20Abdul[1].pdfen_US
dc.subjectIndomethacinen_US
dc.subjectFicus carica fruit mucilageen_US
dc.subjecttransdermal patchesen_US
dc.subjectin-vitro permeationen_US
dc.subjectskin irritationen_US
dc.titleFabrication and in- vitro permeation studies of indomethacin-ficus carica fruit mucilage patches.en_US
dc.typeArticleen_US
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