In vivo antioxidant and lipid peroxidation effect of methanolic extract of tuberous root of Ipomoea digitata (Linn) in rat fed with high fat diet.
Loading...
Date
2010-08
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The study was carried out to determine the in vivo antioxidant and lipid
peroxidation effect of methanolic extract of tuberous root of Ipomoea digitata (Linn). High fat
diet rats showed significantly (P<0.001) reduced the levels of tissues enzymatic antioxidant and
enhanced the level of non enzymatic antioxidant (Glutathione). The level of TBARS are elevated
in HFD rats (group II) when compared with control group. High fat diet induces the oxidative
stress in cell by producing reactive oxygen species. Administration of methanolic extract of
Ipomoea digitata in high fat diet rats were showed increased the levels of antioxidant Enzymes
such as Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx),
Glutathione reductase (GR) and reduced the level of non enzymatic antioxidant Glutathione
(GSH) when compared with HFD rats (Group II). The methanolic extract Ipomoea digitata in
high fat diet rats were found lowered the concentration of TBARS when compared with HFD
rats. Based on the results, we concluded that the methanolic extract of Ipomoea digitata is a
significant source of natural antioxidant, which might be helpful in preventing the progress of
various oxidative stresses.
Description
Keywords
High fat diet, Ipomoea digitata, Antioxidant activity, rats
Citation
Alagumanivasagam G, Muthu A Kottai, Kumar D Satheesh, Suresh K, Manavalan R. In vivo antioxidant and lipid peroxidation effect of methanolic extract of tuberous root of Ipomoea digitata (Linn) in rat fed with high fat diet. International Journal of Applied Biology and Pharmaceutical Technology. 2010 Aug-Oct; 1(2): 214-220.