Syndrome of malnutrition-inflammation complex in chronic alcoholics.
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Date
2010-07
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Abstract
Several studies have reported elevated serum ferritin levels in patients of chronic alcohol abuse. We hypothesized that serum
ferritin may be acting as a marker of acute phase reactant, reflecting the inflammatory status of patients of chronic alcohol abuse, rather
than as a marker of iron overload . Hence we correlated serum ferritin levels with interleukin 6 (IL-6), interleukin 1 (IL-1) and tumor
necrosis factor alpha (TNF -α ) which are markers of inflammation. Serum ferritin and IL-6 levels were significantly elevated at the time of
admission. The elevation of IL-6 correlated well with the increase in ferritin levels (r=0.78, p<0.01). Serum iron levels were not
significantly different before and after abstinence from alcohol. We also speculated that the inflammatory status was associated with the
malnutrition that is observed in alcohol abuse. Therefore we studied serum total protein, albumin, prealbumin and transferrin levels as
markers of nutrition in patients of chronic alcohol abuse. Serum levels of all these nutritional parameters increased significantly after 8
weeks of abstinence from alcohol and were accompanied by reduced levels of ferritin and IL-6. Hence it is possible that a malnutrition
inflammation complex like syndrome exists in patients of alcohol abuse.
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Keywords
Ferritin, acute phase reactant, chronic alcohol abuse, Malnutrition – Inflammation – Complex Syndrome” (MICS)
Citation
Suneetha N, Devika Rani K, Padma Rupa, Shruti Mohanty, Pragna Rao. Syndrome of malnutrition-inflammation complex in chronic alcoholics. National Journal of Integrated Research in Medicine. 2010 Jul-Sept; 1(3): 16-22.