Syndrome of malnutrition-inflammation complex in chronic alcoholics.

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dc.contributor.authorSuneetha, N
dc.contributor.authorDevika, Rani K
dc.contributor.authorPadma, Rupa
dc.contributor.authorShruti, Mohanty
dc.contributor.authorPragna, Rao
dc.date.accessioned2014-07-12T07:23:41Z
dc.date.available2014-07-12T07:23:41Z
dc.date.issued2010-07
dc.description.abstractSeveral studies have reported elevated serum ferritin levels in patients of chronic alcohol abuse. We hypothesized that serum ferritin may be acting as a marker of acute phase reactant, reflecting the inflammatory status of patients of chronic alcohol abuse, rather than as a marker of iron overload . Hence we correlated serum ferritin levels with interleukin 6 (IL-6), interleukin 1 (IL-1) and tumor necrosis factor alpha (TNF -α ) which are markers of inflammation. Serum ferritin and IL-6 levels were significantly elevated at the time of admission. The elevation of IL-6 correlated well with the increase in ferritin levels (r=0.78, p<0.01). Serum iron levels were not significantly different before and after abstinence from alcohol. We also speculated that the inflammatory status was associated with the malnutrition that is observed in alcohol abuse. Therefore we studied serum total protein, albumin, prealbumin and transferrin levels as markers of nutrition in patients of chronic alcohol abuse. Serum levels of all these nutritional parameters increased significantly after 8 weeks of abstinence from alcohol and were accompanied by reduced levels of ferritin and IL-6. Hence it is possible that a malnutrition inflammation complex like syndrome exists in patients of alcohol abuse.en_US
dc.identifier.citationSuneetha N, Devika Rani K, Padma Rupa, Shruti Mohanty, Pragna Rao. Syndrome of malnutrition-inflammation complex in chronic alcoholics. National Journal of Integrated Research in Medicine. 2010 Jul-Sept; 1(3): 16-22.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/152573
dc.language.isoenen_US
dc.source.urihttps://www.scopemed.org/?mno=3289en_US
dc.subjectFerritinen_US
dc.subjectacute phase reactanten_US
dc.subjectchronic alcohol abuseen_US
dc.subjectMalnutrition – Inflammation – Complex Syndrome” (MICS)en_US
dc.titleSyndrome of malnutrition-inflammation complex in chronic alcoholics.en_US
dc.typeArticleen_US
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