Induction of tumour necrosis factor alpha in experimental animals treated with hepatotoxicants.
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1992-08-01
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Abstract
Administrations of hepatotoxicants namely carbon tetrachloride (CCl4:0.4 ml in 1.2 ml of liquid paraffin) and ANIT (1 ml of 1.5% solution in liquid paraffin) in Charles foster rats (force fed) and D-galactosamine (8 mg in water per swiss albino mouse, ip) induce the release of TNF-alpha in case of CCl4 and D-galactosamine. High TNF-alpha level was observed up to 48 hr in CCl4 and up to 24 hr in D-galactosamine treated animals. Elevated levels of biochemical like ALP and SGPT are also recorded. TNF-alpha level can be measured of tissue damage and prognosis in case of hepatitis.
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Roy A, Soni GR, Kolhapure RM, Banerjee K, Patki PS. Induction of tumour necrosis factor alpha in experimental animals treated with hepatotoxicants. Indian Journal of Experimental Biology. 1992 Aug; 30(8): 696-700