Comparison of Anthropometry, Insulin Resistance and Lipid Parameters in Nondiabetics with and without Family History of Type 2 Diabetes Mellitus.
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Date
2013-04
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Abstract
Type 2 DM is a complex metabolic syndrome characterized by impaired insulin secretion and insulin
resistance (IR). IR has a strong genetic component and the children of diabetics have an increased risk for
the early onset of DM.The body mass index (BMI), waist circumference (WC), blood pressure (BP),
fasting plasma glucose (FPG), fasting plasma insulin (FPI), HOMA-IR (Homeostatic model assessment -
IR) and lipid parameters were measured and statistically compared in 25 nondiabetics with family history
of type 2 DM (FH + group) and 25 age matched nondiabetics without family history of type 2 DM (FH -
group).The FPI (8.76 ± 3.6), HOMA-IR (1.95 ± 0.86) and serum triglycerides (136.43 ± 11.44) were
statistically significant (p<0.05) in the FH + group when compared to the FH - group. WC, total cholesterol
and BP showed a trend towards increase in the FH + group. There is hyperinsulinemia, IR and an altered
lipid metabolism in the FH + group. The complex genetic predisposition to IR and its association with the
increasing WC in the FH + group predisposes such individuals to the development of type 2 DM.
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Keywords
Body Mass Index, Type 2 Diabetes Mellitus, Waist Circumference
Citation
G Dayananda, Devi Kusuma, Murthy Niranjan, Kumaran Sendil. Comparison of Anthropometry, Insulin Resistance and Lipid Parameters in Nondiabetics with and without Family History of Type 2 Diabetes Mellitus. JK Science Journal of Medical Education and Research. 2013 Apr-June 15(2): 59-62.