The Protective Effect of Coriandium sativum Extract on Hepato-renal Toxicity Induced in Irradiated Rats.

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dc.contributor.authorFahmy, H A
dc.contributor.authorShreif, N H
dc.contributor.authorGharib, O A
dc.date.accessioned2015-10-08T07:13:03Z
dc.date.available2015-10-08T07:13:03Z
dc.date.issued2014-02
dc.description.abstractAim: The aim of this study was to examine the effect of ethanolic extract of coriander leaves as a potent in vivo antioxidant agent in an effort of finding possible sources of antioxidants for future use in food and pharmaceutical formulations. Study Design: Randomized controlled experiment. Place and Duration of Study: Experimental Animal Unit, Drug Radiation Research Department, National Center for Radiation Research and Technology, Cairo Egypt. Methodology: Antioxidant activity of ethanol extract of coriander leaves was estimated by oxidative stress induced by radiation exposure with the dose of 4 Gy, Silymarin was used as a reference antioxidant drug in female albino rat. Results: Results of experiment revealed that radiation exposure caused a significant increase in serum caspase3 (0.870± 0.086), alanine transaminase (ALT) activity (24.43± 5.02) as well as urea (42.53± 6.11) and creatinine (0.865± 0.064) levels with an increase in liver and kidney lipid peroxidation (MDA) (307.0± 29.22 & 285.5± 48.93) respectively, while decrease in serum albumin (3.003± 0.355), protein (8.66± 0.436) as well as glutathione (GSH) contents of liver and kidney tissues (63.24± 12.19 & 17.38± 1.414) were estimated respectively. In addition serum globuline level and albumin /globuline ratio showed no significant changes. On the other hand, the administration of coriander (600 mg/kg bw) and silymarin (70 mg/kg bw) pre-treatment effectively prevented these alterations and maintained the antioxidant status. Conclusion: Data from present results revealed that Coriandum Sativum act as an antioxidant agent due to its free radical scavenging and cytoprotective activity.en_US
dc.identifier.citationFahmy H A, Shreif N H, Gharib O A. The Protective Effect of Coriandium sativum Extract on Hepato-renal Toxicity Induced in Irradiated Rats. European Journal of Medicinal Plants. 2014 Feb; 4(2): 196-205.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/164083
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/2725en_US
dc.subjectCoriandium satviumen_US
dc.subjectsilymarinen_US
dc.subjectHepato-renal toxicityen_US
dc.subjectMDAen_US
dc.subjectalbumin/ globulin ratioen_US
dc.titleThe Protective Effect of Coriandium sativum Extract on Hepato-renal Toxicity Induced in Irradiated Rats.en_US
dc.typeArticleen_US
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