The Protective Effect of Coriandium sativum Extract on Hepato-renal Toxicity Induced in Irradiated Rats.
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Date
2014-02
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Abstract
Aim: The aim of this study was to examine the effect of ethanolic extract of coriander
leaves as a potent in vivo antioxidant agent in an effort of finding possible sources of
antioxidants for future use in food and pharmaceutical formulations.
Study Design: Randomized controlled experiment.
Place and Duration of Study: Experimental Animal Unit, Drug Radiation Research
Department, National Center for Radiation Research and Technology, Cairo Egypt.
Methodology: Antioxidant activity of ethanol extract of coriander leaves was estimated by
oxidative stress induced by radiation exposure with the dose of 4 Gy, Silymarin was used
as a reference antioxidant drug in female albino rat.
Results: Results of experiment revealed that radiation exposure caused a significant
increase in serum caspase3 (0.870± 0.086), alanine transaminase (ALT) activity (24.43±
5.02) as well as urea (42.53± 6.11) and creatinine (0.865± 0.064) levels with an increase
in liver and kidney lipid peroxidation (MDA) (307.0± 29.22 & 285.5± 48.93) respectively,
while decrease in serum albumin (3.003± 0.355), protein (8.66± 0.436) as well as
glutathione (GSH) contents of liver and kidney tissues (63.24± 12.19 & 17.38± 1.414)
were estimated respectively. In addition serum globuline level and albumin /globuline ratio showed no significant changes. On the other hand, the administration of coriander (600
mg/kg bw) and silymarin (70 mg/kg bw) pre-treatment effectively prevented these
alterations and maintained the antioxidant status.
Conclusion: Data from present results revealed that Coriandum Sativum act as an
antioxidant agent due to its free radical scavenging and cytoprotective activity.
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Keywords
Coriandium satvium, silymarin, Hepato-renal toxicity, MDA, albumin/ globulin ratio
Citation
Fahmy H A, Shreif N H, Gharib O A. The Protective Effect of Coriandium sativum Extract on Hepato-renal Toxicity Induced in Irradiated Rats. European Journal of Medicinal Plants. 2014 Feb; 4(2): 196-205.