Antinociceptive Effect of Ethanolic Extract of Hybanthus enneaspermus Leaf in Rats.
dc.contributor.author | Afolabi, A O | |
dc.contributor.author | Oluwakanmi, E T | |
dc.contributor.author | Salahdeen, H M | |
dc.contributor.author | Oyekunle, A O | |
dc.contributor.author | Alagbonsi, I A | |
dc.date.accessioned | 2016-03-01T11:00:12Z | |
dc.date.available | 2016-03-01T11:00:12Z | |
dc.date.issued | 2014-01-01 | |
dc.description.abstract | Aims: To test the hypothesis that Hybanthus enneaspermus leaf has an antinociceptive effect. Methodology: Seventy-two male rats were randomly divided in a blinded fashion into 4 groups each for the tail immersion test (n=12 per group) and formalin test (n=6 per group). Group 1 (control) received 0.6 ml of distilled water. Group 2 received 100 mg/kg of acetaminophen (paracetamol). Group 3 and 4 received 500 mg/kg and 1000 mg/kg of ethanolic extract of Hybanthus enneaspermus leaf (EEHE) respectively. Results: In the formalin test, oral administration of 500 mg/kg and 1000 mg/kg EEHE caused inhibitions of 62.48% and 72% in the early phase and 70.54% and 78.63% in the late phase respectively. The 1000 mg/kg dose significantly reduced the paw licking time when compared to the standard drug (acetaminophen) in the formalin test. The 500 mg/kg and 1000 mg/kg doses significantly increased the tail flick latency in a manner comparable to acetaminophen. Conclusion: This study showed that the leaf has an anti-nociceptive effect. | en_US |
dc.identifier.citation | Afolabi A O, Oluwakanmi E T, Salahdeen H M, Oyekunle A O, Alagbonsi I A. Antinociceptive Effect of Ethanolic Extract of Hybanthus enneaspermus Leaf in Rats.British Journal of Medicine and Medical Research. 2014 Jan; 4(1): 322-330. | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/174903 | |
dc.language.iso | en | en_US |
dc.source.uri | https://sciencedomain.org/abstract/2045 | en_US |
dc.subject | Acetaminophen | en_US |
dc.subject | analgesic | en_US |
dc.subject | formalin test | en_US |
dc.subject | Hybanthus enneaspermus | en_US |
dc.subject | pain | en_US |
dc.subject | tail flick test | en_US |
dc.title | Antinociceptive Effect of Ethanolic Extract of Hybanthus enneaspermus Leaf in Rats. | en_US |
dc.type | Article | en_US |
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