Antinociceptive Effect of Ethanolic Extract of Hybanthus enneaspermus Leaf in Rats.
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Date
2014-01-01
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Abstract
Aims: To test the hypothesis that Hybanthus enneaspermus leaf has an antinociceptive
effect.
Methodology: Seventy-two male rats were randomly divided in a blinded fashion into 4
groups each for the tail immersion test (n=12 per group) and formalin test (n=6 per
group). Group 1 (control) received 0.6 ml of distilled water. Group 2 received 100 mg/kg
of acetaminophen (paracetamol). Group 3 and 4 received 500 mg/kg and 1000 mg/kg of
ethanolic extract of Hybanthus enneaspermus leaf (EEHE) respectively.
Results: In the formalin test, oral administration of 500 mg/kg and 1000 mg/kg EEHE
caused inhibitions of 62.48% and 72% in the early phase and 70.54% and 78.63% in the late phase respectively. The 1000 mg/kg dose significantly reduced the paw licking time
when compared to the standard drug (acetaminophen) in the formalin test. The 500
mg/kg and 1000 mg/kg doses significantly increased the tail flick latency in a manner
comparable to acetaminophen.
Conclusion: This study showed that the leaf has an anti-nociceptive effect.
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Keywords
Acetaminophen, analgesic, formalin test, Hybanthus enneaspermus, pain, tail flick test
Citation
Afolabi A O, Oluwakanmi E T, Salahdeen H M, Oyekunle A O, Alagbonsi I A. Antinociceptive Effect of Ethanolic Extract of Hybanthus enneaspermus Leaf in Rats.British Journal of Medicine and Medical Research. 2014 Jan; 4(1): 322-330.