Effect of Dichloromethane-Ethanol Extract of Morinda Morindoides (Backer) Milne-Redhead (Rubiaceae) (Etde) on Rabbit Carotid Blood Pressure.

dc.contributor.authorLucien, Boga Gogo
dc.contributor.authorDavid, Trébissou Jonhson Noel
dc.contributor.authorCalixte, Bahi
dc.contributor.authorAdrien, Kouangbe Mani
dc.contributor.authorNoel, Zirihi Guédé
dc.date.accessioned2015-10-12T09:50:39Z
dc.date.available2015-10-12T09:50:39Z
dc.date.issued2013-07
dc.description.abstractMorinda morindoides (Backer) Milne-Redhead (Rubiaceae) is used by the people of west and central Africa for the treatment of diarrhea. The dichloromethane/ethanol extract of M. morindoides (Back) (ETDE) known to be used orally, will be in direct contact with the nobles organs. This study is conduced to see if this extract has effects on the body more precisely on blood pressure. ETDE injected intravenously (10.40 mg/kg b.w to 31.19 mg/kg b.w) provoked a decrease in the arterial blood pressure (hypotension) in a dose-dependent manner (ED50 = 7.08 mg/kg b.w). ETDE at 41.58 mg/kg b.w induce a maximum and irreversible hypotension which leads to the death of the animal. The effects induced by ETDE were inhibited in the presence of atropine at a concentration of 4.46 ×10-4 mg/kg b.w. Our observations, regarding the effects of ETDE on the high blood pressure initiated by adrenaline, showed that the hypertensive effects induced by adrenalin were totally inhibited by ETDE. ETDE induced a dose-dependent hypotension and reversible and his antihypertensive effect could militate for its use in the treatment of hypertension.en_US
dc.identifier.citationLucien Boga Gogo, David Trébissou Jonhson Noel, Calixte Bahi, Adrien Kouangbe Mani, Noel Zirihi Guédé. Effect of Dichloromethane-Ethanol Extract of Morinda Morindoides (Backer) Milne-Redhead (Rubiaceae) (Etde) on Rabbit Carotid Blood Pressure. International Journal of Applied Biology and Pharmaceutical Technology. 2013 Jul-Sept; 4(3): 158-165.en_US
dc.identifier.issn0976-4550
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/164319
dc.language.isoenen_US
dc.source.urihttps://www.ijabpt.com/Details.aspx?id=844en_US
dc.subjectMorinda morindoides (Baker) Milne-Redheaden_US
dc.subjecthypotensiveen_US
dc.subjecthypertensiveen_US
dc.subjectantihypertensiveen_US
dc.titleEffect of Dichloromethane-Ethanol Extract of Morinda Morindoides (Backer) Milne-Redhead (Rubiaceae) (Etde) on Rabbit Carotid Blood Pressure.en_US
dc.typeArticleen_US
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