Effect of Dichloromethane-Ethanol Extract of Morinda Morindoides (Backer) Milne-Redhead (Rubiaceae) (Etde) on Rabbit Carotid Blood Pressure.
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Date
2013-07
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Abstract
Morinda morindoides (Backer) Milne-Redhead (Rubiaceae) is used by the people of west and
central Africa for the treatment of diarrhea. The dichloromethane/ethanol extract of M. morindoides (Back)
(ETDE) known to be used orally, will be in direct contact with the nobles organs. This study is conduced to
see if this extract has effects on the body more precisely on blood pressure. ETDE injected intravenously
(10.40 mg/kg b.w to 31.19 mg/kg b.w) provoked a decrease in the arterial blood pressure (hypotension) in a
dose-dependent manner (ED50 = 7.08 mg/kg b.w). ETDE at 41.58 mg/kg b.w induce a maximum and
irreversible hypotension which leads to the death of the animal. The effects induced by ETDE were inhibited
in the presence of atropine at a concentration of 4.46 ×10-4 mg/kg b.w. Our observations, regarding the effects
of ETDE on the high blood pressure initiated by adrenaline, showed that the hypertensive effects induced by
adrenalin were totally inhibited by ETDE. ETDE induced a dose-dependent hypotension and reversible and his
antihypertensive effect could militate for its use in the treatment of hypertension.
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Keywords
Morinda morindoides (Baker) Milne-Redhead, hypotensive, hypertensive, antihypertensive
Citation
Lucien Boga Gogo, David Trébissou Jonhson Noel, Calixte Bahi, Adrien Kouangbe Mani, Noel Zirihi Guédé. Effect of Dichloromethane-Ethanol Extract of Morinda Morindoides (Backer) Milne-Redhead (Rubiaceae) (Etde) on Rabbit Carotid Blood Pressure. International Journal of Applied Biology and Pharmaceutical Technology. 2013 Jul-Sept; 4(3): 158-165.