Analysis of time-dependent recovery from beryllium toxicity following chelation therapy and antioxidant supplementation.

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dc.contributor.authorJohri, Soniaen_US
dc.contributor.authorShrivastava, Sadhanaen_US
dc.contributor.authorSharma, Pragyaen_US
dc.contributor.authorShukla, Sangeetaen_US
dc.date.accessioned2009-05-28T13:07:36Z
dc.date.available2009-05-28T13:07:36Z
dc.date.issued2004-08-03en_US
dc.description.abstractEfforts have been made to minimize the toxic effect caused by beryllium. Adult cyclic rats of Sprague Dawley strain were administered a bolus dose of 50mg/kg beryllium nitrate intramuscularly. The chelation therapy with glutathione (GSH), dimercapto propane sulfonic acid (DMPS)+ selenium (Se) and D-Penicillamine (DPA) + Se was given for 3 days followed by a rest of 1,3 and 7 days respectively. The results revealed a significant fall in the blood sugar level, serum alkaline phosphatase activity, serum proteins. A significant rise in the transaminases i.e. aspartate aminotranferase and alanine aminotranferase pattern is indicative of leakage of enzymes from liver resulting in alterations in the cell permeability. A rise in the hepatic lipid peroxidation activity is a direct indication of oxidative damage resulting in free radical generation. Results of the distribution studies by atomic absorption spectrophotometry reveal an increased concentration of beryllium in liver and kidney followed by lung and uterus. The relative ability of 3 chelating agents to act as antagonists for acute beryllium poisoning have been examined in liver, kidney, lungs and uterus. The appreciable change in the beryllium concentration in various organs is duration-dependent during the entire period being highly significant after 7 days rest. From the biochemical assays, and distribution studies it can be assumed that DPA+Se was the most effective therapeutic agent followed by DMPS+Se and GSH. Thus it can be concluded that DPA+Se is a better therapeutic agent as compared to DMPS+Se and GSH.en_US
dc.description.affiliationLaboratory of Toxicology & Reproductive Biology, School of Studies in Zoology, Jiwaji University, Gwalior, India.en_US
dc.identifier.citationJohri S, Shrivastava S, Sharma P, Shukla S. Analysis of time-dependent recovery from beryllium toxicity following chelation therapy and antioxidant supplementation. Indian Journal of Experimental Biology. 2004 Aug; 42(8): 798-802en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58997
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidants --administration & dosageen_US
dc.subject.meshBeryllium --toxicityen_US
dc.subject.meshChelation Therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlutathione --administration & dosageen_US
dc.subject.meshKidney --drug effectsen_US
dc.subject.meshLipid Peroxidation --drug effectsen_US
dc.subject.meshLiver --drug effectsen_US
dc.subject.meshPenicillamine --administration & dosageen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSelenium --administration & dosageen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshUnithiol --administration & dosageen_US
dc.titleAnalysis of time-dependent recovery from beryllium toxicity following chelation therapy and antioxidant supplementation.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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