Evaluation of the Effects of Methanolic Extract of Alligator Pepper (Aframomum melegueta) on Serum creatinine, Blood Urea Nitrogen and Electrolytes in Wistar Albino Rats.
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Date
2015
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Abstract
The effect of methanolic extract of Alligator pepper (Aframomum melegueta) (AME) on the serum
creatinine, blood urea nitrogen (BUN) and electrolytes were investigated in Wistar albino rats. The
extraction was done by cold maceration of pulverized seeds in absolute methanol for 48 hours. The
extract was filtered and concentrated in vacuo in a rotary evaporator at 40ÂșC. Twenty four male albino Wistar rats were randomly assigned into four groups of six animals each. Group A served as
the control and received 10 ml/kg of 5 % Tween 20 while Group B-D received 100, 200 and 400
mg/kg respectively, of the AME for 21 days. Twenty four hours later, blood was collected from the
rats through direct cardiac puncture. The separated serum was used to determine the serum
creatinine, BUN and electrolyte assay. The extract produced no significant (p > 0.05) difference in
mean serum creatinine, BUN and electrolytes level in the treated rats when compared to the control
group rats. In conclusion the extract did not exhibit any adverse effect on the kidney at the doses
used and for the period of experiment.
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Keywords
Aframomum melegueta, creatinine, blood urea nitrogen, electrolyte
Citation
Onoja S O, Ezeja M I, Omeh Y N, Ekwulu J T. Evaluation of the Effects of Methanolic Extract of Alligator Pepper (Aframomum melegueta) on Serum creatinine, Blood Urea Nitrogen and Electrolytes in Wistar Albino Rats. International Journal of Biochemistry Research & Review 2015 6(1): 11-17.