OPTIMIZING DRUG DOSING IN CRITICALLY ILL PATIENTS WITH AUGMENTED RENAL CLEARANCE: A COMPREHENSIVE REVIEW AND META-ANALYSIS

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dc.contributor.authorCHACHAR, Men_US
dc.contributor.authorLOKHANDE, Ten_US
dc.contributor.authorKUMBHAR, Aen_US
dc.contributor.authorCHAVAN, Ren_US
dc.contributor.authorSHINDE, D.en_US
dc.date.accessioned2025-05-12T07:20:48Z
dc.date.available2025-05-12T07:20:48Z
dc.date.issued2024-11
dc.description.abstractRenal clearance plays a pivotal role in eliminating most administered drugs, particularly antibiotics, which is crucial for achieving therapeutic goals by maintaining plasma concentrations within the therapeutic window. Various pre-existing conditions such as renal replacement therapies, kidney or liver impairment, and enhanced excretory organ function can disrupt drug concentrations, leading to treatment failure. Augmented Renal Clearance (ARC) exacerbates this by causing rapid drug elimination, notably in critically ill patients. Consequently, careful monitoring and adjustment of drug dosages tailored to individual patient conditions and comorbidities are imperative to prevent sub-therapeutic outcomes or treatment failures. Our review highlights the necessity of dosage modifications informed by current research to optimize therapeutic outcomes in such cases. We provide a comprehensive table detailing effective antibiotics and their adjustments for ARC.en_US
dc.identifier.affiliationsDepartment of Clinical Pharmacy, Modern College of Pharmacy, Nigdi, Pune, Indiaen_US
dc.identifier.affiliationsDepartment of Clinical Pharmacy, Modern College of Pharmacy, Nigdi, Pune, Indiaen_US
dc.identifier.affiliationsDepartment of Clinical Pharmacy, Modern College of Pharmacy, Nigdi, Pune, Indiaen_US
dc.identifier.affiliationsDepartment of Clinical Pharmacy, Modern College of Pharmacy, Nigdi, Pune, Indiaen_US
dc.identifier.affiliationsIntensive and Pediatric Care Clinical Pharmacist, Deenanath Mangeshkar Hospital and Research Center, Pune, Indiaen_US
dc.identifier.citationCHACHAR M, LOKHANDE T, KUMBHAR A, CHAVAN R, SHINDE D.. OPTIMIZING DRUG DOSING IN CRITICALLY ILL PATIENTS WITH AUGMENTED RENAL CLEARANCE: A COMPREHENSIVE REVIEW AND META-ANALYSIS . International Journal of Pharmacy and Pharmaceutical Sciences . 2024 Nov; 16(11): 17-23en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246444
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber11en_US
dc.relation.volume16en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2024v16i11.52092en_US
dc.subjectAugmented renal clearanceen_US
dc.subjectCritically ill patientsen_US
dc.subjectAntibiotic dose adjustmentsen_US
dc.subjectTreatment failureen_US
dc.subjectIncreased doseen_US
dc.subjecteGFRen_US
dc.subjectCreatinine clearanceen_US
dc.titleOPTIMIZING DRUG DOSING IN CRITICALLY ILL PATIENTS WITH AUGMENTED RENAL CLEARANCE: A COMPREHENSIVE REVIEW AND META-ANALYSISen_US
dc.typeJournal Articleen_US
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