OPTIMIZING DRUG DOSING IN CRITICALLY ILL PATIENTS WITH AUGMENTED RENAL CLEARANCE: A COMPREHENSIVE REVIEW AND META-ANALYSIS
No Thumbnail Available
Date
2024-11
Journal Title
Journal ISSN
Volume Title
Publisher
Innovare Academic Sciences Pvt. Ltd.
Abstract
Renal clearance plays a pivotal role in eliminating most administered drugs, particularly antibiotics, which is crucial for achieving therapeutic goals by maintaining plasma concentrations within the therapeutic window. Various pre-existing conditions such as renal replacement therapies, kidney or liver impairment, and enhanced excretory organ function can disrupt drug concentrations, leading to treatment failure. Augmented Renal Clearance (ARC) exacerbates this by causing rapid drug elimination, notably in critically ill patients. Consequently, careful monitoring and adjustment of drug dosages tailored to individual patient conditions and comorbidities are imperative to prevent sub-therapeutic outcomes or treatment failures. Our review highlights the necessity of dosage modifications informed by current research to optimize therapeutic outcomes in such cases. We provide a comprehensive table detailing effective antibiotics and their adjustments for ARC.
Description
Keywords
Augmented renal clearance, Critically ill patients, Antibiotic dose adjustments, Treatment failure, Increased dose, eGFR, Creatinine clearance
Citation
CHACHAR M, LOKHANDE T, KUMBHAR A, CHAVAN R, SHINDE D.. OPTIMIZING DRUG DOSING IN CRITICALLY ILL PATIENTS WITH AUGMENTED RENAL CLEARANCE: A COMPREHENSIVE REVIEW AND META-ANALYSIS . International Journal of Pharmacy and Pharmaceutical Sciences . 2024 Nov; 16(11): 17-23