Bio-equivalence study of two tilmicosin phosphate formulations (Micotil 300� and Cozina 300�) in broiler chickens

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dc.contributor.authorElkomy, Ashrafen_US
dc.contributor.authorAboubakr, Mohameden_US
dc.date.accessioned2020-04-23T08:01:41Z
dc.date.available2020-04-23T08:01:41Z
dc.date.issued2020-04
dc.description.abstractBackground: The present study was designed to assess the comparative bio-equivalence of Micotil 300� and Cozina 300� in healthy broiler chickens after oral administration of both products in a dose of 15 mg tilmicosin base/kg body wt.Methods: Twenty four broiler chickens were divided equally into two groups (12 chickens for each group). The first group was designed to study the pharmacokinetics of Micotil 300�, while the 2nd group was designed to study the pharmacokinetics of Cozina 300�. Each broiler chicken in both groups was orally administered with 15 mg tilmicosin/kg body wt. Blood samples were obtained from the wing vein and collected immediately before and at 0.08, 0.16, 0.25, 0.5, 1, 2, 4, 6, 8, 12 and 24 hours after a single oral administration.Results: The disposition kinetics of Micotil 300� and Cozina 300� following oral administration of 15 mg tilmicosin/kg body wt revealed that the maximum blood concentration [Cmax] were 1.73 and 1.67 ?g/ml and attained at [tmax] of 2.01 and 2.04 hours, respectively.Conclusions: Cozina 300� is bioequivalent to Micotil 300� since the ratios of Cmax, AUC0-24 andAUC0-? (T/R) were 0.96, 0.93 and 0.91 respectively. These are within the bio-equivalence acceptance range. Micotil 300� and Cozina 300� are therefore bioequivalent and interchangeable.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Faculty of Veterinary Medicine, Benha University, Egypten_US
dc.identifier.citationElkomy Ashraf, Aboubakr Mohamed. Bio-equivalence study of two tilmicosin phosphate formulations (Micotil 300� and Cozina 300�) in broiler chickens. International Journal of Basic & Clinical Pharmacology. 2020 Apr; 9(4): 523-527en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200581
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20201103en_US
dc.subjectPharmacokineticsen_US
dc.subjectChickensen_US
dc.subjectTilmicosinen_US
dc.titleBio-equivalence study of two tilmicosin phosphate formulations (Micotil 300� and Cozina 300�) in broiler chickensen_US
dc.typeJournal Articleen_US
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