Bio-equivalence study of two tilmicosin phosphate formulations (Micotil 300� and Cozina 300�) in broiler chickens
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Date
2020-04
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Medip Academy
Abstract
Background: The present study was designed to assess the comparative bio-equivalence of Micotil 300� and Cozina 300� in healthy broiler chickens after oral administration of both products in a dose of 15 mg tilmicosin base/kg body wt.Methods: Twenty four broiler chickens were divided equally into two groups (12 chickens for each group). The first group was designed to study the pharmacokinetics of Micotil 300�, while the 2nd group was designed to study the pharmacokinetics of Cozina 300�. Each broiler chicken in both groups was orally administered with 15 mg tilmicosin/kg body wt. Blood samples were obtained from the wing vein and collected immediately before and at 0.08, 0.16, 0.25, 0.5, 1, 2, 4, 6, 8, 12 and 24 hours after a single oral administration.Results: The disposition kinetics of Micotil 300� and Cozina 300� following oral administration of 15 mg tilmicosin/kg body wt revealed that the maximum blood concentration [Cmax] were 1.73 and 1.67 ?g/ml and attained at [tmax] of 2.01 and 2.04 hours, respectively.Conclusions: Cozina 300� is bioequivalent to Micotil 300� since the ratios of Cmax, AUC0-24 andAUC0-? (T/R) were 0.96, 0.93 and 0.91 respectively. These are within the bio-equivalence acceptance range. Micotil 300� and Cozina 300� are therefore bioequivalent and interchangeable.
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Keywords
Pharmacokinetics, Chickens, Tilmicosin
Citation
Elkomy Ashraf, Aboubakr Mohamed. Bio-equivalence study of two tilmicosin phosphate formulations (Micotil 300� and Cozina 300�) in broiler chickens. International Journal of Basic & Clinical Pharmacology. 2020 Apr; 9(4): 523-527