The Constrained Disorder Principle Accounts for The Structure and Function of Water as An Ultimate Biosensor and Bioreactor in Biological Systems

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dc.contributor.authorIlan, Yaronen_US
dc.date.accessioned2023-08-25T06:43:54Z
dc.date.available2023-08-25T06:43:54Z
dc.date.issued2023-06
dc.description.abstractThe constrained disorder principle (CDP) defines living organisms as systems that comprise an intrinsic disorder bounded by dynamic boundaries. Water plays a substantial role in multiple biological processes affecting nucleic acids' and proteins' structure and function. The paper describes the CDP-accounted water structure dynamicity and variability in water isomers ratio. Per the CDP, the variability in the ratios between water isomers is mandated for the inherent variability of biological systems. This variability underlies water's unique functions and enables the flexibility and adaptability required to cope with internal and external environmental changes. The CDP-dependent water structures also determine energy usage. The paper presents water molecules as ultimate biosensors for stimuli in the environment and as the ultimate bioreactors that respond to perturbations by changing the structure and function of the molecules in their vicinity. Finally, it describes the potential of using water-based signatures of variability to improve artificial intelligence-based algorithms developed for correcting disturbances of biological systems by increasing the degree of disorder in systems or tightening the disorder's boundaries.en_US
dc.identifier.affiliationsDearpartment of Medicine and Hebrew University, Faculty of Medicine, Hadassah Medical Center, Ein-Kerem, Jerusalem, Israelen_US
dc.identifier.affiliationsDepartment of Neurology, Hebrew University, Faculty of Medicine, and Hadassah Medical Center, Department of Medicine, Jerusalem, Israelen_US
dc.identifier.citationIlan Yaron. The Constrained Disorder Principle Accounts for The Structure and Function of Water as An Ultimate Biosensor and Bioreactor in Biological Systems. International Journal of Applied Biology and Pharmaceutical Technology. 2023 Jun; 14(2): 31-41en_US
dc.identifier.issn0976-4550
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225572
dc.languageenen_US
dc.publisherApplied Biology and Pharmaceutical Sciencesen_US
dc.relation.issuenumber2en_US
dc.relation.volume14en_US
dc.source.urihttps://www.doi.org/10.26502/ijabpt.202123en_US
dc.subjectCDP: constrained disorder principalen_US
dc.titleThe Constrained Disorder Principle Accounts for The Structure and Function of Water as An Ultimate Biosensor and Bioreactor in Biological Systemsen_US
dc.typeJournal Articleen_US
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