Urinary 8‑hydroxydeoxyguanosine as a marker of oxidative stress induced genetic toxicity in oral cancer patients.
dc.contributor.author | Murugaiyan, Sathish Babu | |
dc.contributor.author | Ramasamy, Ramesh | |
dc.contributor.author | Nakkeeran, M | |
dc.contributor.author | Rangdhol, Vishwanath | |
dc.contributor.author | Srinivasan, A R | |
dc.contributor.author | Niranjan, G | |
dc.date.accessioned | 2015-12-31T06:03:48Z | |
dc.date.available | 2015-12-31T06:03:48Z | |
dc.date.issued | 2015-05 | |
dc.description.abstract | Context: Recently, non‑communicable diseases have snatched the lead from infectious diseases in causing mortality. Of these, oral cancer accounts for a significant proportion of deaths. Every year in India significant percentage of newly diagnosed malignancy is oral cancer attributed to various reasons. Aims: The aim of this study was to assess the extent of oxidative stress and its effect on modification of DNA by urinary nucleoside 8-hydroxy-2’-deoxyguanosine (8-OHdG) levels in oral cancer subjects. To see the relationship between the nucleoside 8‑OHdG and antioxidant capacity ferric reducing ability plasma (FRAP) in oral cancer subjects. Settings and Design: Case–control study included three groups with 60 volunteers, who were divided into 30 controls, and equal number of clinically diagnosed oral cancer male patients: (Subdivided into newly diagnosed [n = 15] and 1‑year treatment follow‑up oral cancer subjects [n = 15]). Materials and Methods: A random urine sample was used for analysis of 8‑OHdG concentration. Serum triglycerides, lipid peroxidation, protein thiols, and FRAP assay were performed by spectrophotometric technique. Statistical Analysis Used: Student’s t‑test and one‑way analysis of variance were performed for group comparison and Pearson’s correlation analysis were used. A P < 0.05 was considered the optimum level of significance. Results: The urinary 8‑OHdG and serum malondialdehyde levels were significantly elevated in newly diagnosed oral cancer subjects in their 1‑year treatment compared to the control group (P < 0.05). A significant correlation was observed between urinary 8‑OHdG and FRAP in both groups of oral cancer subjects. Conclusions: Urinary 8‑OHdG can be a useful diagnostic marker of oxidative DNA damage in oral cancer subjects. | en_US |
dc.identifier.citation | Murugaiyan Sathish Babu, Ramasamy Ramesh, Nakkeeran M, Rangdhol Vishwanath, Srinivasan A R, Niranjan G. Urinary 8‑hydroxydeoxyguanosine as a marker of oxidative stress induced genetic toxicity in oral cancer patients. Indian Journal of Dental Research. 2015 May-June; 26(3): 226-230. | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/169372 | |
dc.language.iso | en | en_US |
dc.source.uri | https://www.ijdr.in/article.asp?issn=0970-9290;year=2015;volume=26;issue=3;spage=226;epage=230;aulast=Murugaiyan | en_US |
dc.subject | 8‑hydroxy‑2’‑deoxyguanosine | en_US |
dc.subject | ferric reducing ability plasma | en_US |
dc.subject | marker | en_US |
dc.subject | malondialdehyde | en_US |
dc.subject | oral cancer | en_US |
dc.title | Urinary 8‑hydroxydeoxyguanosine as a marker of oxidative stress induced genetic toxicity in oral cancer patients. | en_US |
dc.type | Article | en_US |
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