Malignant Melanoma of Anal Canal – A Diagnostic Dilemma

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dc.contributor.authorSiddiqui, Bushraen_US
dc.contributor.authorFaridi, Shahbaz Habiben_US
dc.contributor.authorAhmad, Syed Shamshaden_US
dc.contributor.authorAkhtar, Kafilen_US
dc.contributor.authorRehman, Suhailuren_US
dc.contributor.authorAijaz, Mohsinen_US
dc.date.accessioned2019-11-16T07:23:16Z
dc.date.available2019-11-16T07:23:16Z
dc.date.issued2016-04
dc.description.abstractA 50-year-old male presented with major complaints of bleeding per -rectum and generalized weakness for past one and a half month. Digital rectal examination (DRE) and colonoscopy revealed a thrombosed internal haemorrhoid, which was surgically excised. Histopathological examination (HPE) was pointing towards anal malignant melanoma, which was further confirmed by positive immunohistochemistry (IHC) for HMB-45. As the patient had no secondaries or lymph node enlargement, he was referred for loco-regional radiotherapy. Primary ano-rectal melanoma is a rare but locally aggressive neoplasm capable of early metastasis. Owing to its non-specific clinical presentation it may be mistaken for benign conditions like haemorrhoids and may prove fatal.  Surgical treatment may range from wide local excision (WLE) to abdomino-perineal resection (APR) with controversial role of chemo-radiation in advanced cases. Prognosis is usually bleak with a 5-year survival rate of less than 20%. Owing to the rarity of ano-rectal melanoma and importance of its early detection and management, this case is being reported here.en_US
dc.identifier.affiliationsDepartment of Pathology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment Of Surgery, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.en_US
dc.identifier.affiliationsDepartment of Pathology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, Indiaen_US
dc.identifier.citationSiddiqui Bushra, Faridi Shahbaz Habib, Ahmad Syed Shamshad, Akhtar Kafil, Rehman Suhailur, Aijaz Mohsin. Malignant Melanoma of Anal Canal – A Diagnostic Dilemma. International Archives of BioMedical and Clinical Research. 2016 Apr-Jun; 2(2): 79-82en_US
dc.identifier.issn2454-9894
dc.identifier.issn2454-9886
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/184082
dc.languageenen_US
dc.publisherIbn Sina Academy of Medieval Medicine & Sciencesen_US
dc.relation.issuenumber2en_US
dc.relation.volume2en_US
dc.source.urihttps://doi.org/10.21276/iabcr.2016.2.2.17en_US
dc.subjectMalignant Melanomaen_US
dc.subjectcutaneous Malignanciesen_US
dc.subjectAnal Canalen_US
dc.titleMalignant Melanoma of Anal Canal – A Diagnostic Dilemmaen_US
dc.typeJournal Articleen_US
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