Mechanism responsible for mucoadhesion of mucoadhesive drug delivery system: a review.

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dc.contributor.authorAlexander, Amit
dc.contributor.authorAjazuddin
dc.contributor.authorTripathi, D K
dc.contributor.authorVerma, Tekeshwar
dc.contributor.authorSwarna
dc.contributor.authorMaurya, Jyoti
dc.contributor.authorPatel, Sandip
dc.date.accessioned2015-08-07T06:40:49Z
dc.date.available2015-08-07T06:40:49Z
dc.date.issued2011-01
dc.description.abstractMucoadhesion had been a topic of interest in the design of drug delivery system to prolong the residence time of the dosage form with the under lying absorption surface to improve and enhance the bioavailability of drugs. Mucoadhesion occurs between two surfaces, one of which is a mucous membrane and another is drug delivery system. Pharmaceutical aspects of mucoadhesion had been the subject of great interest during recent years because mucoadhesion could be a solution for bioavailability problems that result from a too short length of stay of the pharmaceutical dosage form at the absorption site within the gastro-intestinal tract. It had been a great challenge to the pharmaceutical sciences in order to enhance localised drug delivery or to deliver ‘difficult’ molecules (proteins and oligonucleotides) into the systemic circulation. Mucoadhesive systems remain in close contact with the absorption tissue, the mucous membrane releasing the drug at the action site leading to increase in bioavailability (both local and systemic effects). Extending the residence time of a dosage form at a particular site and controlling the release of drug from the dosage form are useful especially for achieving controlled plasma level of the drug as well as improving bioavailability. The main objective of this study was to selectively collect the data which were extended the gastrointestinal residence time of the dosage form and controlled the release of mucoadhesives.en_US
dc.identifier.citationAlexander Amit, Ajazuddin, Tripathi D K, Verma Tekeshwar, Swarna, Maurya Jyoti, Patel Sandip. Mechanism responsible for mucoadhesion of mucoadhesive drug delivery system: a review. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Jan-Mar; 2(1): 434-445.en_US
dc.identifier.issn0976-4550
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/161517
dc.language.isoenen_US
dc.source.urihttps://www.ijabpt.com/Details.aspx?fid=257en_US
dc.subjectBioadhesionen_US
dc.subjectMucoadhesionen_US
dc.subjectBioavailabilityen_US
dc.subjectGastrointestinal residence timeen_US
dc.subjectMechanism of mucoadhesionen_US
dc.titleMechanism responsible for mucoadhesion of mucoadhesive drug delivery system: a review.en_US
dc.typeArticleen_US
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