Mechanism responsible for mucoadhesion of mucoadhesive drug delivery system: a review.
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Date
2011-01
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Abstract
Mucoadhesion had been a topic of interest in the design of drug delivery system to prolong
the residence time of the dosage form with the under lying absorption surface to improve and enhance the
bioavailability of drugs. Mucoadhesion occurs between two surfaces, one of which is a mucous
membrane and another is drug delivery system. Pharmaceutical aspects of mucoadhesion had been the
subject of great interest during recent years because mucoadhesion could be a solution for bioavailability
problems that result from a too short length of stay of the pharmaceutical dosage form at the absorption
site within the gastro-intestinal tract. It had been a great challenge to the pharmaceutical sciences in order
to enhance localised drug delivery or to deliver ‘difficult’ molecules (proteins and oligonucleotides) into
the systemic circulation. Mucoadhesive systems remain in close contact with the absorption tissue, the
mucous membrane releasing the drug at the action site leading to increase in bioavailability (both local
and systemic effects). Extending the residence time of a dosage form at a particular site and controlling
the release of drug from the dosage form are useful especially for achieving controlled plasma level of the
drug as well as improving bioavailability. The main objective of this study was to selectively collect the
data which were extended the gastrointestinal residence time of the dosage form and controlled the
release of mucoadhesives.
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Keywords
Bioadhesion, Mucoadhesion, Bioavailability, Gastrointestinal residence time, Mechanism of mucoadhesion
Citation
Alexander Amit, Ajazuddin, Tripathi D K, Verma Tekeshwar, Swarna, Maurya Jyoti, Patel Sandip. Mechanism responsible for mucoadhesion of mucoadhesive drug delivery system: a review. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Jan-Mar; 2(1): 434-445.