Isolated angiokeratomas of the tongue: A rare entity
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Date
2019-03
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Society for Dental Research
Abstract
Angiokeratomas consist of ectasias of dermal capillaries associated with an acanthotic and hyperkeratotic overlying epidermis. These dark red-to-purple, papular vascular anomalies can vary considerably in size, depth, and location. It is a skin disorder that rarely involves oral cavity. It can occur in localized or generalized form and is often associated with underlying metabolic disorder such as Fabry's disease and fucosidosis. It has many clinical variants with the same underlying histopathology. Mucosal involvement, including the oral cavity, is occasionally found either as a component of the systemic variety, called angiokeratoma corporis diffusum, or associated with cutaneous lesions in more locations. Isolated oral involvement seems to be rather infrequent, and only eighteen cases have been described in the world literature thus far. Isolated multiple angiokeratomas of tongue without plaque formation have been reported only four times before this. Here, we report a fifth case of isolated multiple angiokeratomas of tongue in a 16-year-old female which was confirmed by immunohistochemical pattern in consonance with a blood vessel origin, with expression of CD31, CD34, and von Willebrand factor. The lesion did not express D2-40 and CD45. No other malformation or metabolic disorder was found in the patient.
Description
Keywords
Angiokeratoma, immuno‑histochemical, isolated, oral cavity, tongue, tumor
Citation
Hamid Rizwan, Chalkoo Altaf H, Singh Inderpreet, Wani Suhail, Bilal Sheikh. Isolated angiokeratomas of the tongue: A rare entity. Indian Journal of Dental Research. 2019 Mar; 30(2): 322-326