Cerebellar granule cell membranes and glutamate mediates transactivation of glutamine synthetase promoter.

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dc.contributor.authorKedar, Ven_US
dc.contributor.authorPurohit, Hen_US
dc.contributor.authorFreeze, Een_US
dc.contributor.authorHempel, Fen_US
dc.date.accessioned2009-05-28T15:12:50Z
dc.date.available2009-05-28T15:12:50Z
dc.date.issued1997-02-01en_US
dc.description.abstractPotential region of glutamine synthetase promoter driving astrocyte-specific transactivation, mediated by cerebellar granule cell membrane and glutamate has been identified by deletion analysis of promoter and transient transfection. The promoter region from -420 to -765 was found to be potentially important for this transactivation. These results provided further evidence for importance of neuronal-glial and glutamate-glial interactions in regulation of glial gene expression.en_US
dc.description.affiliationLaboratory of Molecular Biology, National Institute of Neurological Disorders and Strokes, National Institute of Health, Bethesda, MD 20892, USA. vishramK@qimr.edu.auen_US
dc.identifier.citationKedar V, Purohit H, Freeze E, Hempel F. Cerebellar granule cell membranes and glutamate mediates transactivation of glutamine synthetase promoter. Indian Journal of Experimental Biology. 1997 Feb; 35(2): 123-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61700
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAstrocytes --cytologyen_US
dc.subject.meshCerebellum --cytologyen_US
dc.subject.meshCytoplasmic Granules --physiologyen_US
dc.subject.meshGlutamate-Ammonia Ligase --geneticsen_US
dc.subject.meshGlutamic Acid --physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIntracellular Membranes --physiologyen_US
dc.subject.meshMutagenesis, Site-Directeden_US
dc.subject.meshNeurons --cytologyen_US
dc.subject.meshPromoter Regions, Geneticen_US
dc.subject.meshTranscriptional Activationen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleCerebellar granule cell membranes and glutamate mediates transactivation of glutamine synthetase promoter.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, U.S. Gov't, P.H.S.en_US
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