Antimicrobial and Antiinflammatory Potential of the Swedish Herbs Extract.
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Date
2011-10
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Abstract
Oral conditions that produce the greatest damage on individuals are cavities and
periodontal disease, hence non-expensive and effective solutions are immediately
required, particularly for communities with no access to dental services. The
antimicrobial and anti-inflammatory potential of the Swedish bitter herbal extract was
evaluated, using pure microbial cultures and clinical samples of 29 patients. It was
observed that the extract caused significant (p<0.05) in vitro growth inhibition of up to
29%, 17%, 15%, and 50% against Prevotella intermedia, Bacteroides forsythus,
Porphyromonas gingivalis and Streptococcus intermedius, respectively. In addition, the
extract significantly (p<0.05) inhibited oral flora growth in patient samples showing MICs
of < 7.8 μg/ml in 21% of the patients, 15.6μg/ml in 17% of the patients, 31.2 μg/ml in
10% of the patients, 62.5 μg/ml in 17% of the patients, 125 μg/ml in 3% of the patients,
and 250 μg/ml in 7% of the patients, and induced a maximum of 75% growth inhibition,
as measured by the MTT reduction assay. The extract was also observed to significantly
suppress production of the inflammatory marker nitric oxide by LPS-treated murine
peritoneal macrophages. The Swedish herbal extract may be considered in the clinics to prevent or treat bacterial oral infections and at the same time reducing inflammation.
Description
Keywords
Bacteria, inflammation, medicinal plants, oral infection, Swedish herbal extract
Citation
Gomez-Flores R, González-Meléndez R, Ceballos-Salobreña A, Tamez-Guerra P, Tamez-Guerra R, Rodríguez-Padilla C, Monreal-Cuevas E, Garza-Ramos M A De La. Antimicrobial and Antiinflammatory Potential of the Swedish Herbs Extract. European Journal of Medicinal Plants. 2011 Oct-Dec; 1(4): 107-117.