Effect of chloroquine on rat liver mitochondria.

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dc.contributor.authorDeepalakshmi, P Den_US
dc.contributor.authorParasakthy, Ken_US
dc.contributor.authorShanthi, Sen_US
dc.contributor.authorDevaraj, N Sen_US
dc.date.accessioned2009-05-28T13:35:34Z
dc.date.available2009-05-28T13:35:34Z
dc.date.issued1994-11-01en_US
dc.description.abstractChloroquine causes an increase in phospholipid and a decrease in cholesterol in liver mitochondria. A significant decrease in the activities of mitochondrial inner membrane enzymes such as NADH dehydrogenase, succinate dehydrogenase and cytochrome c oxidase is observed. Decrease in cytochrome contents and respiratory control ratio, shown by a decrease in state 3(+ADP) and an increase in state 4 (-ADP), implies decreased ATP synthesis following chloroquine administration. The results confirm drug-induced inhibition of mitochondrial respiration, thereby impairing availability and utilisation of energy.en_US
dc.description.affiliationDepartment of Biochemistry, University of Madras, India.en_US
dc.identifier.citationDeepalakshmi PD, Parasakthy K, Shanthi S, Devaraj NS. Effect of chloroquine on rat liver mitochondria. Indian Journal of Experimental Biology. 1994 Nov; 32(11): 797-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59612
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChloroquine --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMitochondria, Liver --drug effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.titleEffect of chloroquine on rat liver mitochondria.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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