Effect of chloroquine on rat liver mitochondria.

No Thumbnail Available
Date
1994-11-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Chloroquine causes an increase in phospholipid and a decrease in cholesterol in liver mitochondria. A significant decrease in the activities of mitochondrial inner membrane enzymes such as NADH dehydrogenase, succinate dehydrogenase and cytochrome c oxidase is observed. Decrease in cytochrome contents and respiratory control ratio, shown by a decrease in state 3(+ADP) and an increase in state 4 (-ADP), implies decreased ATP synthesis following chloroquine administration. The results confirm drug-induced inhibition of mitochondrial respiration, thereby impairing availability and utilisation of energy.
Description
Keywords
Citation
Deepalakshmi PD, Parasakthy K, Shanthi S, Devaraj NS. Effect of chloroquine on rat liver mitochondria. Indian Journal of Experimental Biology. 1994 Nov; 32(11): 797-9
URI
https://imsear.searo.who.int/handle/123456789/59612
Collections
Indian Journal of Experimental Biology