Usefulness of serology in diagnosis of different clinical presentations of ocular toxoplasmosis

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dc.contributor.authorKrishnankutty, Saritha V.en_US
dc.contributor.authorReni, Philipen_US
dc.contributor.authorNarayani, Vijayammaen_US
dc.date.accessioned2020-05-06T09:52:57Z
dc.date.available2020-05-06T09:52:57Z
dc.date.issued2020-02
dc.description.abstractBackground: Large proportions of acquired cases of ocular toxoplasmosis are reported with atypical presentations. The objectives of the study were to find out whether any correlation existed between serological findings of typical and atypical presentations of ocular toxoplasmosis as compared to cases presenting with non-toxoplasmic uveitis and to find out the proportion of various atypical presentations of ocular toxoplasmosis.Methods: It was a prospective observational study.The study subjects of ocular toxoplasmosis were tested for immunoglobulin M (IgM) and immunoglobulin G (IgG) toxoplasma antibody levels in serum by ELISA (enzyme-linked immunosorbent assay) technique. The proportion of atypical presentation among total toxoplasma cases and distribution of atypical cases were calculated. Fisher’s exact test, one-way analysis of variance and Kruskal-wallis test were used as applicable.Results: Among the cases (n=35) thirteen patients had typical presentation of a retinochoroidal focus with an adjacent scar and 22 patients had atypical features. Control group consisted of 24 patients. Various types of presentations in atypical cases were retinitis patch without an adjacent scar (31.8%), intermediate uveitis (27.3%), papillitis (22.7%) retinal vasculitis and dense vitritis (9.09% each). Mean IgG levels in typical cases (85.3±82.9 IU/ml) and atypical cases (47.5±66.2) were significantly higher than control group (6.6±3.4, p<0.001).Conclusions: Serology is a useful tool in the diagnosis of ocular toxoplasmosis with a compatible clinical picture as serum IgG levels are significantly elevated in both typical and atypical presentations of ocular toxoplasmosis as compared to cases presenting with non-toxoplasmic uveitis.en_US
dc.identifier.affiliationsDepartment of Ophthalmology, Government Medical College, Kottayam, Kerala, Indiaen_US
dc.identifier.citationKrishnankutty Saritha V., Reni Philip, Narayani Vijayamma. Usefulness of serology in diagnosis of different clinical presentations of ocular toxoplasmosis. International Journal of Community Medicine and Public Health. 2020 Feb; 7(2): 517-520en_US
dc.identifier.issn2394-6032
dc.identifier.issn2394-6040
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/202109
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber2en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2394-6040.ijcmph20200418en_US
dc.subjectOcularen_US
dc.subjectToxoplasmosisen_US
dc.subjectTypicalen_US
dc.subjectAtypicalen_US
dc.subjectSerologyen_US
dc.titleUsefulness of serology in diagnosis of different clinical presentations of ocular toxoplasmosisen_US
dc.typeJournal Articleen_US
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International Journal of Community Medicine and Public Health