Protective Impact of Curcumin against Paracetamol-Induced Hepatotoxicity in Rats

Simple item page
dc.contributor.authorFadil, Hosny Abd Elen_US
dc.contributor.authorNagah Edressen_US
dc.contributor.authorNadia Khorshiden_US
dc.contributor.authorNoha Aminen_US
dc.date.accessioned2020-09-24T07:28:36Z
dc.date.available2020-09-24T07:28:36Z
dc.date.issued2019-01
dc.description.abstractThe present study was planned to investigate the protective impact of curcumin on hepatotoxicity of paracetamol in malealbino rats. Thirty-five male albino rats were allocated into seven equal groups, each of five rats, 1st group was kept ascontrol, 2nd group orally administered tween 80 (0.5 ml/200 g b. wt) for 15 days, 3rd group received silymarin (200 mg/kgb. wt) orally for 15 days, 4th group received curcumin (200 mg/kg b. wt) orally for 15 days, 5th group orally administeredparacetamol (500 mg/kg b. wt) for the last 5 days, 6th group was given silymarin and paracetamol, 7th group was givencurcumin and paracetamol. The hepatotoxicity of paracetamol in rats displayed a significant reduction in erythrocytic count(RBCs), concentration of hemoglobin (Hb), the values of packed cell volume (PCV) and mean corpuscular hemoglobinconcentration (MCHC) with a critical elevation in mean corpuscular volume (MCV), platelets (Plts), white blood cells(WBCs) and neutrophils count. Silymarin or curcumin administration with paracetamol in rats produced a significantincrease in RBCs, Hb, PCV and MCHC with a significant decrease in MCV, Plts, WBCs and neutrophils count. Liverenzymes (ALT and AST) and total bilirubin were significantly increased post administration of paracetamol whereasadministration of silymarin or curcumin with paracetamol significantly decreased the activities of liver enzymes and totalbilirubin. Paracetamol administration in rats produced a significant increase in tumor-necrosis factor-alpha (TNF-α) leveland lactate-dehydrogenase enzyme (LDH) activity. Silymarin or curcumin administration with paracetamol displayed acritical decrease in TNF-α and LDH activity. Paracetamol elicited a critical decrease in catalase (CAT), superoxidedismutase (SOD) and glutathione peroxidase (GPX) activities with a critical elevation in malondialdehyde (MDA)concentration. Silymarin or curcumin administration with paracetamol evoked a critical elevation in CAT, SOD and GPXactivities with a significant decrease in MDA concentration. Histopathological examination of paracetamol treated ratsdisplayed alterations in liver histoarchitecture with degenerative and necrotic changes in hepatic cells but restored to nearlynormal picture by pretreatment with silymarin and curcumin. Curcumin has a hepatoprotective effect on paracetamolinduced-hepatotoxicity in rats.en_US
dc.identifier.affiliationsDeptartment of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Egypten_US
dc.identifier.affiliationsDeptartmentof Pharmacology, Faculty of Medicine, Zagazig University, Egypten_US
dc.identifier.affiliationsDirectorate of Veterinary Medicine, Zagazig University, Zagazig, Egypt.en_US
dc.identifier.citationFadil Hosny Abd El, Nagah Edress, Nadia Khorshid, Noha Amin. Protective Impact of Curcumin against Paracetamol-Induced Hepatotoxicity in Rats. International Journal of Medical Research Professionals. 2019 Jan; 8(1): 84-94en_US
dc.identifier.issn2277-3657
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203686
dc.languageenen_US
dc.publisherInternational Journal of Pharmaceutical Research and Allied Sciencesen_US
dc.relation.issuenumber1en_US
dc.relation.volume8en_US
dc.source.urihttps://ijpras.com/storage/models/article/oeuncPiCeVKMdXogDIVkTUYdC5Va8o8KujruXlTPfazqUM83WU0vohamc9Tl/protective-impact-of-curcumin-against-paracetamol-induced-hepatotoxicity-in-rats.pdfen_US
dc.subjectSilymarinen_US
dc.subjectCurcuminen_US
dc.subjectParacetamolen_US
dc.subjectHepatotoxicityen_US
dc.subjectRatsen_US
dc.titleProtective Impact of Curcumin against Paracetamol-Induced Hepatotoxicity in Ratsen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijpras2019v8n1p84.pdf
Size:
814.27 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Pharmaceutical Research and Allied Sciences